Desmoid tumor

A desmoid tumor (sometimes referred to as "aggressive fibromatosis") is a rare (3 per million population) tumor that may or may not be part of a genetic syndrome such as familial adenomatous polyposis (FAP).

Histologically they resemble low-grade fibrosarcomas, but they are very infiltrative and tend to recur even after complete resection (systemic metastasis is rare).

Desmoid tumors may be classified as extra-abdominal, abdominal wall, or intra-abdominal (the last is more common in patients with FAP). It is thought that the lesions may develop in relation to estrogen levels or trauma/operations.

Treatment may consist of watching and waiting, complete surgical removal, radiation therapy, antiestrogens and NSAIDs, or chemotherapy.

Current experimental studies are being done with Gleevec (Imatinib) for treatment of Desmoid tumors, and show promising success rates.


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  • Desmoid tumor — Desmoid tumors are benign soft tissue tumors that occur most often in young adults and involve the limbs or trunk but can also arise in the abdomen or thorax. Desmoid tumors are benign. They never metastasize (spread to other parts of the body).… …   Medical dictionary

  • Desmoid-Tumor — Der Desmoid Tumor ist ein Tumor aus der Gruppe der Fibromatosen, der sich an den Umhüllungen von Muskeln (Muskelfaszien) bildet. Aufgrund seines Verhaltens, der Neigung in das umliegende Gewebe infiltrierend einzuwachsen wird der Desmoid Tumor… …   Deutsch Wikipedia

  • desmoid tumor — A tumor of the tissue that surrounds muscles, usually in the abdomen. A desmoid tumor rarely metastasizes (spreads to other parts of the body). It may be called aggressive fibromatosis when the tumor is outside of the abdomen …   English dictionary of cancer terms

  • Desmoid — Der Desmoid Tumor ist ein strahlenresistenter Tumor aus der Gruppe der Fibromatosen, der sich an den Umhüllungen von Muskeln (Muskelfaszien) bildet. Aufgrund seines Verhaltens, der Neigung in das umliegende Gewebe infiltrierend einzuwachsen wird… …   Deutsch Wikipedia

  • Tumor, desmoid — Desmoid tumors are benign soft tissue tumors that occur most often in young adults and involve the limbs or trunk but can also arise in the abdomen or thorax. Desmoid tumors are benign. They never metastasize (spread to other parts of the body).… …   Medical dictionary

  • desmoid — 1. Fibrous or ligamentous. 2. A nodule or relatively large mass of unusually firm scarlike connective tissue resulting from active proliferation of fibroblasts, occurring most frequently in the abdominal muscles of women who have borne children;… …   Medical dictionary

  • tumor — 1. Any swelling or tumefaction. 2. SYN: neoplasm. 3. One of the four signs of inflammation (t., calor, dolor, rubor) enunciated by Celsus. [L. t., a swelling] acinar cell t. a …   Medical dictionary

  • desmoid — /dez moyd/, adj. Anat., Zool. 1. resembling a fascia or fibrous sheet. 2. resembling a ligament; ligamentous. n. 3. Pathol. a firm and tough tumor of nonmetastasizing, fibrous tissue. [1840 50; < Gk desm(ós) (see DESMID) + OID] * * * …   Universalium

  • desmoid fibromatosis — see under tumor …   Medical dictionary

  • desmoid — /dez moyd/, adj. Anat., Zool. 1. resembling a fascia or fibrous sheet. 2. resembling a ligament; ligamentous. n. 3. Pathol. a firm and tough tumor of nonmetastasizing, fibrous tissue. [1840 50; < Gk desm(ós) (see DESMID) + OID] …   Useful english dictionary


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