Desoxycorticosterone
drugbox
IUPAC_name =
CAS_number = 64-85-7
ATC_prefix = H02
ATC_suffix = AA03
PubChem = 6166
DrugBank =
C=21 | H=30 | O=4
molecular_weight = 330.461
bioavailability =
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elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
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routes_of_administration =Desoxycorticosterone (11-deoxycorticosterone) is a
mineralocorticoid secreted fromZona reticularis andZona fasciculata of theadrenal gland . In thecytosol of themitochondrion ,pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of theendoplasmic reticulum . Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively.Desoxycorticosterone is commonly found in two forms: the
acetate salt (desoxycorticosterone acetate, or DOCA) and thepivalate salt (desoxycorticosterone pivalate). Both forms are given as intramuscular injections as replacement therapy forAddison's disease . This disease is marked by insufficientadrenal function, including low mineralocorticoid levels.Desoxycorticosterone pivalate is sold for
veterinary use byNovartis under the brand name Percoten.References
http://web.indstate.edu/thcme/mwking/steroid-hormones.html
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Look at other dictionaries:
désoxycorticostérone — ● désoxycorticostérone nom féminin Hormone corticosurrénale favorisant la rétention des ions sodium et l excrétion des ions potassium. désoxycortone [dezɔksikɔʀtɔn] ou désoxycorticostérone [dezɔksikɔʀtikosteʀɔn] n. f. ÉTYM. Mil. XXe; de dés (→ 1 … Encyclopédie Universelle
desoxycorticosterone — noun A mineralocorticoid hormone secreted by the adrenal gland. Syn: 11 deoxycorticosterone … Wiktionary
desoxycorticosterone — A steroid derived from the adrenal cortex with strong mineralocorticoid activity. * * * des·oxy·cor·ti·co·ste·rone (.)dez .äk si .kȯrt i käs tə .rōn, i .kō stə rōn or de·oxy·cor·ti·co·ste·rone (.)dē n a steroid hormone C21H30O3 of the adrenal… … Medical dictionary
desoxycorticosterone acetate — [USP] the acetate salt of 11 deoxycorticosterone; used as replacement therapy to treat adrenocortical insufficiency; administered by intramuscular injection … Medical dictionary
desoxycorticosterone pivalate — [USP] the pivalate salt of 11 deoxycorticosterone, used as replacement therapy to treat adrenocortical insufficiency; administered by intramuscular injection … Medical dictionary
DCTMA — desoxycorticosterone trimethyl acetate … Medical dictionary
DCTPA — desoxycorticosterone triphenyl acetate … Medical dictionary
DOC — Désoxycorticostérone. Substance favorisant, dans l organisme, la fixation du sodium et de l eau et l élimination du potassium. Contribue à l entretien de l activité musculaire … Sigles et Acronymes francais
DCTMA — • desoxycorticosterone trimethyl acetate … Dictionary of medical acronyms & abbreviations
DCTPA — • desoxycorticosterone triphenyl acetate … Dictionary of medical acronyms & abbreviations
