Von Braun amide degradation

Von Braun amide degradation

The von Braun amide degradation is the chemical reaction of a monosubstituted amide with phosphorus pentachloride to give a nitrile and an organohalide. [cite journal
title = Ueber die Spaltung des Benzenylmethylimidchlorids
author = Hans von Pechmann
journal = Berichte der deutschen chemischen Gesellschaft
volume = 33
issue = 1
pages = 611–612
year = 1900
url = http://gallica.bnf.fr/ark:/12148/bpt6k907551/f616.table
doi = 10.1002/cber.19000330199
] [cite journal
title = Ueber 1.5-Dibrompentan
author = von Braun, J.
journal = Berichte der deutschen chemischen Gesellschaft
volume = 37
issue = 3
pages = 3210–3213
year = 1904
url =
doi = 10.1002/cber.190403703118
] [cite journal
title = Mechanism of the von Braun amide degradations with carbonyl bromide or phosphorus pentabromide
author = B. A. Phillips, G. Fodor, J. Gal, F. Letourneau and J. J. Ryan
journal = Tetrahedron
volume = 29
issue = 21
pages = 3309–3327
year = 1973
url =
doi = 10.1016/S0040-4020(01)93483-0


ee also

*von Braun reaction

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  • Von Braun reaction — The Von Braun reaction is an organic reaction in which a tertiary amine reacts with cyanogen bromide to an organocyanamide [Von Braun, Heider, and Muller, Ber., 51, 281 (1918).] . An example is the reaction of dimethyl α naphthylamine [Organic… …   Wikipedia

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  • Nitrile — This article is about the group of organic compounds. For the synthetic rubber product, see Nitrile rubber. The structure of the nitrile group A nitrile is any organic compound that has a C≡N functional group.[1] …   Wikipedia

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