2C-T-7

Chembox new
ImageFile1 = 2C-T-7.svg
ImageSize1 = 180px
ImageFile2 = 2C-T-7-3d-sticks.png ImageSize2 = 200px
IUPACName = 2- [2,5-Dimethoxy-4-(propylthio)phenyl] ethanamine
OtherNames = 2,5-Dimethoxy-4-"n"-propylthiophenethylamine
Section1 = Chembox Identifiers
CASNo = 207740-26-9
PubChem =
SMILES = NCCC1=C(OC)C=C(SCCC)C(OC)=C1

Section2 = Chembox Properties
Formula = C13H21NO2S
MolarMass = 255.38 g/mol
Appearance =
Density =
MeltingPt = 140-150 °C at 33.4 Pa
BoilingPt =
Solubility =

Section3 = Chembox Hazards
MainHazards =
FlashPt =
Autoignition =

2C-T-7 is a hallucinogenic phenethylamine of the 2C family. In his book "PiHKAL (Phenethylamines i Have Known And Loved)", Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entheogenic effects that last 8 to 15 hours. [cite web|url=http://www.erowid.org/library/books_online/pihkal/pihkal043.shtml|title=PIHKAL #43|author=Alexander Shulgin] Up until Operation Web Tryp and multiple reported deaths, 2C-T-7 was sold commercially in Dutch smartshops and online as "Blue Mystic".

There has been little real research done on this chemical other than Shulgin's comments in PiHKAL. There have been a few small animal studies mostly aimed at detecting metabolites, and an informal amateur research paper written by an interested party called Sulfurous Samadhi. [ [http://www.erowid.org/chemicals/2ct7/article1/ Sulfurous Samadhi] ]

Pharmacology

The mechanism that produces the hallucinogenic and entheogenic effects of 2C-T-7 is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines. [cite journal|last=Fantegrossi|first=WE|coauthors=Harrington AW, Eckler JR, Arshad S, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH|year=2005|month=September|volume=181|issue=3|pages=496–503|title=Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats|journal=Psychopharmacology (Berlin)|doi=10.1007/s00213-005-0009-4]

As the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase-A inhibitor, 2C-T-7 may likewise have MAO-A inhibitory effects. This could indicate 2C-T-7 is more likely to induce serotonin syndrome than other serotonergic hallucinogens, as at high doses it may slow the degradation of serotonin, a potentially life-threatening condition. [ cite journal|last=Gallardo-Godoy|first=A|coauthors=Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE.|title=Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling|journal=Journal of Medicinal Chemistry|date=April 7, 2005|volume=48|issue=7|pages=2407–19|doi=10.1021/jm0493109]

Several of the deaths involving 2C-T-7 followed co-administration of the drug with stimulants such as MDMA and ephedrine.Fact|date=May 2008

Effects

2C-T-7 is hallucinogenic. In PiHKAL, Shulgin writes that the hallucinations are unique. He also comments on the tenseness of his muscles and his change in voice tone, which lasted some days. Erowid gives the following effects list:

Positive

* sense of well-being (enhanced lucidity, sense of inner peace)
* emotional opening
* significant closed and open eye visuals
* increased appreciation of music

Neutral

* general change in consciousness (as with most psychoactives)
* pupil dilation
* change in perception of time
* visual hallucinations
* auditory hallucinations

Negative

* nausea and vomiting
* muscle tension
* irritating body load
* muscle tremors and/or convulsions
* memory loss (at higher doses)
* delirium (at higher doses) (potentially dangerous)
* violent behaviour (at higher doses)

The drug can be taken orally or snorted, although nasal administration is reported to be extremely painful. [cite web|url=http://www.eastbayexpress.com/issues/2002-05-01/news/feature.html|title=2C-T-7's Bad Trip|author=East Bay Express|date=01-02-07] Use of 2C-T-7 as a nootropic at low doses of 1-10mg has been reported, and it may be useful for this purpose in a similar manner to LSD, which shows modest stimulant and nootropic effects at doses of 10 µg.

Deaths

The Partnership for a Drug-Free America reports that 2C-T-7 can be lethal even in small doses, [cite web|url=http://www.drugfree.org/Portal/Drug_guide/2C-B_2C-T-7|title=2C-B, 2C-T-7|author=Partnership for a Drug-Free America|authorlink=Partnership for a Drug-Free America|accessdate=2006-10-04] . There have been at least three reported deaths related to 2C-T-7 use, mainly at insufflated doses of 30mg or more or combined with stimulants such as MDMA, as well as a number of very bad trips and hospitalizations, these mostly followed insufflation of 2C-T-7 Fact|date=May 2008. In January 2002, "Rolling Stone" published an article about 2C-T-7 entitled "The New (legal) Killer Drug", although the legal status of the drug was misrepresented in the article. It can cause nausea and, as with many other drugs, may be dangerous when combined with alcohol and/or stimulants.

Legality

Around the year 2000, 2C-T-7 began to change from an obscure chemical to a drug used at parties and clubs in North America and Europe as it became available through a number of grey-market commercial vendors. This aroused the attention of the authorities, and since many countries have scheduled the chemical.

Australia

In Australia, 2C-T-2 and 2C-T-7 are covered by the country's comparatively strict analogue drug laws.

Canada

2C-T-7 is unscheduled in Canada.

The Netherlands

The Netherlands was the first country in the world to ban 2C-T-7, after being sold in smartshops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market, but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.

weden

2C-T-2 became commercially available in Sweden in the summer of 1998, being sold in smartshops similar to those in the Netherlands. On April 1, 1999, both 2C-T-2 and 2C-T-7, along with MBDB, BDB, 2C-B and PMMA, were banned in Sweden. This was not done by appending these drugs to the country's normal drug laws, but by passing a new law, "Förordning (1999:58) om förbud mot vissa hälsofarliga varor," which banned the drugs as being materials dangerous to health.

UK

In 1999, Alexander Shulgin was sent a copy of a letter from the British Home Office to several of its administrative associates which in effect placed all compounds listed in PiHKAL into Class A, Britain's equivalent of Schedule I.

US

On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a Final Rule in the Federal Register permanently placing 2C-T-7 in Schedule I. (69 FR 12794). [ cite web|url=http://www.dea.gov/programs/forensicsci/microgram/mg0104/mg0104.html|title=Micgrogram Bulletin Jan 2004|author=DEA] [cite web|url=http://www.usdoj.gov/ndic/pubs11/12207/12207p.pdf|title=2C-T-7 Fast Facts|author=U.S. Department of Justice] [ [http://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm List of Schedule 1 drugs on the DEA Office of Diversion Control website] ]

Notes

ee also

* Aleph-7
* 2C-B
* 2C-T-21

External links

* [http://erowid.org/chemicals/2ct7/ Erowid 2C-T-7 Vault]
* [http://www.erowid.org/library/books_online/pihkal/pihkal043.shtml PiHKAL #43 2C-T-7] by Alexander Shulgin
* [http://www.erowid.org/chemicals/2ct7/article1/article1.shtml Sulfurous Samadhi: An Investigation of 2C-T-2 & 2C-T-7] by Murple
* [http://www.erowid.org/chemicals/2ct7/2ct7_effects.shtml Effects list from Erowid]


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