Brimonidine

drugbox
IUPAC_name = 5-Bromo-"N"-(4,5-dihydro-1"H"-imidazol-2-yl) quinoxalin-6-amine
width=260



CAS_number = 59803-98-4
ATC_prefix = S01
ATC_suffix = EA05
ATC_supplemental =
PubChem = 2435
DrugBank = APRD00034
C=11 | H=10 | Br=1 | N=5
molecular_weight = 292.135 g/mol
bioavailability =
protein_bound =
metabolism = liver primarily
elimination_half-life = 3 hours
pregnancy_category = B
legal_status = unknown
routes_of_administration = Ocular, 1 gtt

Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or ocular hypertension. Alphagan is also used to induce miosis for people suffering from poor night vision after Lasik or PRK surgery.

It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye. As a treatment for glaucoma, it is usually given in eyedrop form.

Brimonidine is an α2-adrenergic receptor agonist.

Alpha 2 agonists, through the activation of the Gi GPCR, inhibit the production of AC. This reduces cAMP and hence Aqueous Humour production by the ciliary body.

Clinical uses

Brimonidine is indicated for the lowering of intraocular pressure in patients with open-angleglaucoma or ocular hypertension.

External links

* [http://www.alphaganp.com/ Alphagan P product website]
* [http://www.alphaganp.com/ALPHGANP.pdf Alphagan P prescribing information]

References

* "Mosby's Drug Guide for Nurses" (7th edition; Skidmore) 2007.


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