IUPAC_name = 5-Bromo-"N"-(4,5-dihydro-1"H"-imidazol-2-yl) quinoxalin-6-amine
CAS_number = 59803-98-4
ATC_prefix = S01
ATC_suffix = EA05
PubChem = 2435
DrugBank = APRD00034
C=11 | H=10 | Br=1 | N=5
molecular_weight = 292.135 g/mol
metabolism = liver primarily
elimination_half-life = 3 hours
pregnancy_category = B
legal_status = unknown
routes_of_administration = Ocular, 1 gtt
Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or
ocular hypertension. Alphagan is also used to induce miosisfor people suffering from poor night vision after Lasik or PRK surgery.
It acts via decreasing synthesis of
aqueous humor, and increasing the amount that drains from the eye. As a treatment for glaucoma, it is usually given in eyedrop form.
Brimonidine is an α2-adrenergic receptor agonist.
Alpha 2 agonists, through the activation of the Gi GPCR, inhibit the production of AC. This reduces cAMP and hence Aqueous Humour production by the ciliary body.
Brimonidine is indicated for the lowering of intraocular pressure in patients with open-angleglaucoma or ocular hypertension.
* [http://www.alphaganp.com/ Alphagan P product website]
* [http://www.alphaganp.com/ALPHGANP.pdf Alphagan P prescribing information]
* "Mosby's Drug Guide for Nurses" (7th edition; Skidmore) 2007.
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