Cetylpyridinium chloride

Cetylpyridinium chloride
CAS number 123-03-5 YesY
6004-24-6 (monohydrate)
PubChem 31239
ChemSpider 28979 YesY
ChEBI CHEBI:32915 YesY
ATC code B05CA01D08AJ03, D09AA07, R02AA06
Beilstein Reference 3578606
Jmol-3D images Image 1
Molecular formula C21H38ClN
Molar mass 339.99 g mol−1
Appearance solid
Melting point

77 °C, 350 K, 171 °F

LD50 36 mg/kg (rabbit, iv)[1]
400 mg/kg (rabbit, oral)[1]
6 mg/kg (rat, ip)[1]
30 mg/kg (rat, iv)[1]
200 mg/kg (rat, oral)[1]
250 mg/kg (rat, sc)[1]
10 mg/kg (mouse, ip)[1]
108 mg/kg (mouse, oral)[1]
 YesY chloride (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound in some types of mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. It is an antiseptic that kills bacteria and other microorganisms. It has been shown to be effective in preventing dental plaque and reducing gingivitis.[2] It has also been used as an ingredient in certain pesticides. However, this ingredient has also been alleged (according to WebMD,[3] eMedicine,[4]) to cause brown stains between the teeth and on the surface of teeth similar to chlorhexidine rinse. However, these stains can be easily removed by a dentist during a routine check-up. There have been reports of taste alteration accompanying the use of cetylpyridinium chloride mouthwash.[3] [4]



Cetylpyridinium chloride is present in commercial products such as 1-palmitylpyridinium chloride, C16-alkylpyridinium chloride, 1-hexadecylpyridinium chloride, acetoquat CPC, aktivex, ammonyx CPC, cecure, ceepryn chloride, cepacol, ceprim, cepacol chloride, cetafilm, cetamium, dobendan, halset, ipanol, medilave, mercocet, merothol, pionin B, pristacin, pyrisept, and asept.

Physical and chemical properties

Cetylpyridinium chloride has the molecular formula C21H38NCl and at its pure form is in a solid state at room temperature. It has a melting point of 77 °C when anhydrous or 80–83 °C in its monohydrate form. It is insoluble in acetone, acetic acid, or ethanol. It has a pyridine-like odor. It is combustible. Concentrated solutions are destructive to mucous membranes. It is toxic when swallowed and very toxic when inhaled.

In some products, cetylpyridinium bromide is used instead. Its properties are virtually identical.

Its critical micelle concentration (CMC) is 0.00124M, corresponding to 0.042% in water.

Toxicology and pharmacology

IVN-RAT LD50 30 mg kg−1[1]

ORL-RBT LD50 400 mg kg−1[1]

IVN-RBT LD50 36 mg kg−1[1]

Compendial status

See also


External links

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Look at other dictionaries:

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  • cetylpyridinium chloride — “+... noun Etymology: cetyl + pyridinium : a white powder consisting of a quaternary ammonium salt C21H38ClN.H2O and used as a cationic detergent and antiseptic …   Useful english dictionary

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  • Mouthwash — This article is about the hygiene product. For the Kate Nash song, see Mouthwash (song). For the ska punk band, see Mouthwash (band). Mouthwash or mouth rinse is a product used to enhance oral hygiene. Some manufacturers of mouthwash claim that… …   Wikipedia

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