PROSITE is a database of protein families and domains. It consists of entries describing the domains, families and functional sites as well as amino acid patterns, signatures, and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation. PROSITE was created in 1988 by Amos Bairoch.

Its uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. PROSITE offers tools for protein sequence analysis and motif detection (see sequence motif). It is part of the ExPASy proteomics analysis servers.

The database ProRule builds on the domain descriptions of PROSITE. It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, substrate- or co-factor-binding sites, posttranslational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.

ee also

* Uniprot the universal protein database, a central resource on protein information - PROSITE adds data to it.
* InterPro a centralized database, grouping data from databases of protein families, domains and functional sites - part of the data come from PROSITE.
* Protein subcellular localization prediction another example of use of PROSITE.





External links

* [ ProRule] - Database of rules based on PROSITE predictors

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Look at other dictionaries:

  • PROSITE — es una base de datos de familias y dominios de proteínas creada por Amos Bairoch en 1988.[1] [2] Consiste en entradas que describen dominios, familias y sitios funcionales así como patrones de aminoácidos. Estos son manualmente verificados por un …   Wikipedia Español

  • PROSITE — ist eine Datenbank für Protein Familien und Domänen, die 1988 von Amos Bairoch erstellt wurde.[1] In den Datenbank Einträgen werden die Domänen, Familien und funktionellen Gruppen von Proteinen beschrieben. Die Datenbank wird von Mitarbeitern des …   Deutsch Wikipedia

  • Prosite — Searchable dictionary of conserved protein domains. Useful in inferring likely function of novel proteins …   Dictionary of molecular biology

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