PROSITE


PROSITE

PROSITE is a database of protein families and domains. It consists of entries describing the domains, families and functional sites as well as amino acid patterns, signatures, and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation. PROSITE was created in 1988 by Amos Bairoch.

Its uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. PROSITE offers tools for protein sequence analysis and motif detection (see sequence motif). It is part of the ExPASy proteomics analysis servers.

The database ProRule builds on the domain descriptions of PROSITE. It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites, substrate- or co-factor-binding sites, posttranslational modification sites or disulfide bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.

ee also

* Uniprot the universal protein database, a central resource on protein information - PROSITE adds data to it.
* InterPro a centralized database, grouping data from databases of protein families, domains and functional sites - part of the data come from PROSITE.
* Protein subcellular localization prediction another example of use of PROSITE.

References

*

*

*

External links

*http://www.expasy.org/prosite/
* [http://www.expasy.org/prosite/prorule.html ProRule] - Database of rules based on PROSITE predictors


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • PROSITE — es una base de datos de familias y dominios de proteínas creada por Amos Bairoch en 1988.[1] [2] Consiste en entradas que describen dominios, familias y sitios funcionales así como patrones de aminoácidos. Estos son manualmente verificados por un …   Wikipedia Español

  • PROSITE — ist eine Datenbank für Protein Familien und Domänen, die 1988 von Amos Bairoch erstellt wurde.[1] In den Datenbank Einträgen werden die Domänen, Familien und funktionellen Gruppen von Proteinen beschrieben. Die Datenbank wird von Mitarbeitern des …   Deutsch Wikipedia

  • Prosite — Searchable dictionary of conserved protein domains. Useful in inferring likely function of novel proteins …   Dictionary of molecular biology

  • Sequence motif — In genetics, a sequence motif is a nucleotide or amino acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance. For proteins, a sequence motif is distinguished from a structural motif, a motif formed …   Wikipedia

  • C2 domain — Pfam box Symbol = C2 Name = C2 domain width =200 caption = The C2 domain of C.absonum α toxin (PDB 1OLP). β strands are shown in yellow. Co ordinated Calcium ions are in cyan Pfam= PF00168 InterPro= IPR000008 SMART= C2 PROSITE = PDOC00380 SCOP =… …   Wikipedia

  • Spider toxin — Pfam box Symbol = Toxin 9 Name = Spider toxin width = caption = Pfam= PF02819 InterPro= IPR004169 SMART= Prosite = SCOP = 1oav TCDB = OPM family= 120 OPM protein= 1agg PDB=PDB3|1iva :4 48 PDB3|1oaw :4 48 PDB3|1oav :4 48PDB3|1agg :39 83 PDB3|1omb …   Wikipedia

  • Superoxid-Dismutase — Superoxiddismutase Modell des Dimer der menschlichen zytoplasmatischen SOD nach PDB …   Deutsch Wikipedia

  • Saposin protein domain — Identifiers Symbol SapA Pfam PF02199 InterPro IPR003119 …   Wikipedia

  • Peroxidasen — Bezeichner Gen Name(n) …   Deutsch Wikipedia

  • Superoxide dismutase — For other senses of the term SOD/Sod, see Sod (disambiguation). Superoxide dismutase Structure of a human Mn superoxide dismutase 2 tetramer.[1] …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.