Citrinin

Citrinin[1]
Identifiers
CAS number 518-75-2 YesY
UNII 3S697X6SNZ N
KEGG C16765 N
ChEMBL CHEMBL510139 N
Jmol-3D images Image 1
Properties
Molecular formula C13H14O5
Molar mass 250.25 g mol−1
Appearance Lemon-yellow needles
Melting point

175 °C (decomp.)

Solubility in water Insoluble
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Citrinin is a mycotoxin originally isolated from Penicillium citrinum. It has since been found to be produced by a variety of other fungi which are used in the production of human foods such as grain, cheese, sake and red pigments. Citrinin has also been found in commercial red yeast rice supplements.[2]

Contents

Toxicity

Citrinin acts as a nephrotoxin in all species in which it has been tested, but its acute toxicity varies.[3] It causes mycotoxic nephropathy in livestock and has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans.

Citrinin is used as a reagent in biological research. It induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain.

Citrinin producers

Citrinin is produced by a variety of fungi including:

Notes

  1. ^ Merck Index, 11th Edition, 2329.
  2. ^ Gordon, R. Y.; Cooperman, T.; Obermeyer, W.; Becker, D. J. (2010). "Marked Variability of Monacolin Levels in Commercial Red Yeast Rice Products: Buyer Beware!". Archives of Internal Medicine 170 (19): 1722–1727. doi:10.1001/archinternmed.2010.382. PMID 20975018. 
  3. ^ Bennett, J. W.; Klich, M. (2003). "Mycotoxins.". Clinical Microbiology Reviews 16 (3): 497–516. doi:10.1128/CMR.16.3.497-516.2003. PMC 164220. PMID 12857779. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164220. 
  4. ^ citrinin product page from Fermentek

References

  • E.J. Da Lozzo et al. J. Biochem. Mol. Toxicol. 1998 12 291
  • G.M. Chagas et al. J. Appl. Toxicol. 1995 15 91
  • D.Heperkan,B.E.Meriç,G.Şişmanoğlu,G.Dalkılıç,F.Güler. In: Advances in Experimental Medicine & Biology. Edited by A.D. Hocking; J.I.Pitt, R.A.Samson & U.Thrane.2006 571
  • Ö.Tokuşoğlu,H.Alpas,F.Bozoğlu. Effect of High Hydrostatic Pressure (HHP) on Mycotoxin Citrinin, Major Phenolics Oleuropein, Hydroxytyrosol, and Total Antioxidant Activity in Black Table Olives. 135-26 Technical Research Paper. 2008 IFT Annual Meeting+Food Expo. June 28-July 1, New Orleans, LA, USA.2008 183

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Citrinin — Strukturformel Allgemeines Name Citrinin Andere Namen …   Deutsch Wikipedia

  • citrinin — noun Etymology: New Latin citrinum, specific epithet of Penicillium citrinum Date: 1931 a toxic antibiotic C13H14O5 that is produced especially by a penicillium (Penicillium citrinum) and an aspergillus (Aspergillus niveus) and is effective… …   New Collegiate Dictionary

  • Citrinin — Ci|t|ri|nin [nlat. Penicillium citrinum, ein Schimmelpilz (Mikrobiol.); ↑ in (3)], das; s: gelbes, für Lebensmittelvergiftungen durch Getreide verantwortliches Mykotoxin …   Universal-Lexikon

  • citrinin — ci·tri·nin si trī nən n a toxic antibiotic C13H14O5 that is produced esp. by two molds of the genus Penicillium (P. citrinum) and the genus Aspergillus (A. niveus) and is effective against some gram positive bacteria * * * cit·ri·nin (sitґrĭ …   Medical dictionary

  • citrinin — ci·tri·nin …   English syllables

  • citrinin — sə̇.ˈtrīnə̇n noun ( s) Etymology: New Latin citrinum (specific epithet of Penicillium citrinum) + English in : a toxic antibiotic C13H14O5 that is produced by certain molds (especially Penicillium citrinum) and is bactericidal towards some gram… …   Useful english dictionary

  • Mycotoxin — A mycotoxin (from Greek μύκης (mykes, mukos) “fungus” and Latin (toxicum) “poison”)[1][2] is a toxic secondary metabolite produced by organisms of the fungus kingdom, commonly known as molds.[3][4] The term ‘mycotoxin’ is usually reserved for the …   Wikipedia

  • Beri-Beri — Klassifikation nach ICD 10 E51.1 Beriberi …   Deutsch Wikipedia

  • Beriberi — Klassifikation nach ICD 10 E51.1 Beriberi …   Deutsch Wikipedia

  • Chemikalienliste — Die Chemikalienliste stellt eine alphabetisch sortierte Liste von Chemikalien dar, ohne Anspruch auf Vollständigkeit. Elemente sind fett gekennzeichnet, Stoffgruppen kursiv. Der Haupteintrag zu einer Chemikalie ist gleichzeitig der Name des… …   Deutsch Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.