Estramustine


Estramustine

drugbox
IUPAC_name = (17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17- decahydro-6H-cyclopenta [a] phenanthren-3-yl) bis (2-chloroethyl)aminomethanoate






CAS_number = 2998-57-4
ATC_prefix = L01
ATC_suffix = XX11
PubChem = 18140
DrugBank = APRD00625
C = 23 |H = 31 |Cl = 2 |N = 1 |O = 3
molecular_weight = 440.403 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 20 hours
pregnancy_category =
legal_status =
routes_of_administration =

Estramustine (Emcyt) is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen (specifically, estradiol) with an nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.

Estramustine is marketed in the United States by Pharmacia (now a subsidiary of Pfizer)


Mechlorethamine.
Estradiol.

Clinical uses

Estramustine is indicated for the palliative treatment of metastatic and/or progressive carcinoma of the prostate.

External links

* [http://www.pfizer.com/files/products/uspi_emcyt.pdf Emcyt prescribing information]


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