- Skin whitening
The term "skin whitening" covers a variety of cosmetic methods used to whiten the
skin. It is most common in parts of Africaand Asia.
Skin lightening or whitening is a controversial topic as it is closely intertwined with the detrimental effects on
health, identity, self image, racial supremacyand colonial mentality.Fact|date=July 2008
There is evidence to suggest that some active ingredients used in publicly available skin-whitening products can be harmful. [Counter, S. Allen, "Whitening skin can be deadly",
Boston Globe, 16 Dec. 2003 [http://www.boston.com/news/globe/health_science/articles/2003/12/16/whitening_skin_can_be_deadly/] ]
Specific zones of abnormally high pigmentation such as moles and
birthmarks may be depigmented to match to the surrounding skin. Conversely, in cases of vitiligo, unaffected skin may be lightened to achieve a more uniform appearance. The reason for singer Michael Jackson's change in skin is due to vitiligo and depigmentationwas used to achieve a more matching appearance. [Rashid, Aliya, "A rush to cream the fairness fetish", Daily News & Analysis, India, September 01, 2006 [http://www.dnaindia.com/report.asp?NewsID=1050554] ]
Some people treat larger areas to lighten the natural
complexion, out of aesthetic preference or to avoid social/work discrimination and gain access to better income or higher social position. This kind of colorismcommonly occurs in India. [http://www.ecpat.net/eng/ecpat_inter/Publication/Other/English/Pdf_page/ecpat_sex_tourism_dom_rebublic.pdf]
An additional application is genital or
anal bleaching, intended to reduce the typically darker pigmentation of the genital and perianal area.
geishawere (and still are) known for their painted white skin, which represents beauty, grace, and high social status. However, the skin-whitening products are not used in such a wide scale in Japan today. Geisha paint their skin white in geisha-based ceremonies to celebrate their culture and background.
Persia, during the Achaemenid dynasty, farmers and civil workers used pure hydroquinoneto keep their skin clear and soft.Fact|date=September 2008
Today, skin whitening products are available in the form of creams, pills, soaps or lotions. The mechanism of permanent whitening is usually by the breakdown of
melaninby enzymes, such as that contained in the droppings of the Japanese bush warbleror reducing agents such as hydroquinone. Most whitening creams also contain a UV block to prevent sun damage to the skin.
Melanin and pigmentation
Uneven pigmentation affects most people, regardless of ethnic background or skin color. Skin may either appear lighter or darker than normal; there may be blotchy, uneven areas, patches of brown to gray discoloration or freckling. Skin pigmentation disorders occur because the body produces either too much or too little
melanin. Melanin is the pigment produced by melanocytecells. It is triggered by an enzymecalled tyrosinase, which creates the color of skin, eyes, and hair shades.
Melanin has two major forms that combine to create varying skin tones.
Eumelaninproduces a range of brown skin and hair color, while pheomelaninimparts a yellow to reddish hue.
Melanin provides some amount of sun protection for the skin by absorbing ultraviolet light. Darker skin colors are less susceptible to
sunburnand the overall effects of sun damage.
Increased melanin production — also known as
hyperpigmentation— is often referred to as melasma, chloasmaor solar lentigenes.
* Melasma is a general term describing darkening of the skin.
* Chloasma is generally used to describe skin discolorations caused by hormones. These hormonal changes are usually the result of pregnancy, birth control pills or estrogen replacement therapy.
* Solar lentigenes is the technical term for darkened spots on the skin caused by the sun. Solar refers to sunlight and lentigene describes a darkened area of skin. These spots are quite common in adults with a long history of unprotected sun exposure.
Aside from sun exposure and hormones, hyperpigmentation can be caused by skin damage, such as remnants of blemishes, wounds or rashes. [Cutis, August 2005, pp 19-23] This is especially true for those with darker skin tones.
The most typical cause of darkened areas of skin, brown spots or areas of discoloration is unprotected sun exposure. Once incorrectly referred to as
liver spots, these pigment problems are not connected with the liver.
On lighter to medium skin tones, solar lentigenes emerge as small- to medium-sized brown patches of freckling that can grow and accumulate over time on areas of the body that receive the most unprotected sun exposure, such as the back of the hands, forearms, chest, and face. For those with darker skin colors, these discolorations can appear as patches or areas of ashen-gray skin.
Most skin-lightening treatments, which can reduce or block some amount of melanin production, are aimed at inhibiting tyrosinase. Many treatments use a combination of topical lotions or gels containing melanin-inhibiting ingredients along with a sunscreen, and a prescription
retinoid. Depending on how the skin responds to these treatments, exfoliants — either in the form of topical cosmetic or chemical peels — and lasers may be used. ["Journal of the American Academy of Dermatology", May 2006, supplemental, pages 272-281; "Dermatologic Surgery", March 2006, pages 365-371; "Journal of Drugs in Dermatology", September-October 2004, supplemental, 27-34; "International Journal of Dermatology", December 2003, pages 966-972; and "Archives of Dermatology", December 2002, pages 1578-1582).]
Sunscreen is a product used to protect the skin from ultraviolet rays, to avoid damage and/or darkening of the skin. Some sunscreens can be used to lighten the skin, too. Higher SPFs contain greater quantities of the UVA-protecting ingredients
titanium dioxide, zinc oxideor avobenzone. ["Journal of the American Academy of Dermatology", May 2005, pages 786-792; "American Journal of Epidemiology", April 2005, pages 620-627; and "The British Journal of Dermatology", December 1996, pages 867-875.]
hydroquinoneis considered by many dermatologists to be a safer, similarly effective (if not more so), and less expensive option than lasers or deep peel treatments. Topical hydroquinone comes in 2% (available in cosmetics) to 4% (or more) concentrations (available from a physician or by prescription), alone or in combination with tretinoin 0.05% to 0.1%. Research has shown hydroquinone and tretinoin to be powerful tools against sun- or hormone-induced melasma. ["Dermatologic Surgery", March 2006, pages 365-371.]
Hydroquinone has been shown to cause leukemia in mice and other animals. The European Union banned it from cosmetics in 2001, but it shows up in bootleg creams in the developing world. It is sold in the United States as an over-the-counter drug, but with a concentration of hydroquinone not exceeding 2 percent. [ [http://www.nytimes.com/2006/05/14/world/asia/14thailand.html?scp=7&sq=skin+whitening&st=nyt A Vision of Pale Beauty Carries Risks for Asia's Women - New York Times ] ]
Some research has shown topical
azelaic acidin 15% to 20% concentrations to be as efficacious as hydroquinone with a decreased risk of irritation. Tretinoin by itself has also been shown to be useful in treating hyperpigmentation of sun-damaged skin. Kojic acid, alone or in combination with glycolic acidor hydroquinone, also has shown good results due to its inhibitory action on tyrosinase (though kojic acid has had problems in terms of stability and potential negative effects on the skin and is rarely used today). Several plant extracts and vitamin C also have some research showing them to be effective for inhibiting melanin production. ["Journal of the American Academy of Dermatology", May 2006, pages S272-S281; "International Journal of Dermatology", August 2004, pages 604-607; and "The American Journal of Clinical Dermatology", September-October 2000, pages 261-268).]
Many skin whiteners contain toxic mercury such as
mercury(II) chlorideor ammoniated mercuryas the active ingredient. [cite web
title=Skin lightening products
In medical literature, hydroquinone is considered the primary topical ingredient for inhibiting melanin production. ["Cutis", March 2006, pages 177-184; "Journal of Drugs in Dermatology", September-October 2005, pages 592-597; "Journal of Cosmetic Science", May-June 1998, pages 208-290; "Dermatological Surgery", May 1996, pages 443-447.] Its components have potent antioxidant abilities. ["Journal of Natural Products", November 2002, pages 1605-1611.]
Hydroquinone is a strong inhibitor of melanin production, meaning that it prevents skin from making the substance responsible for skin color. ["Journal of Dermatological Science", August, 2001, supplemental, pages 68-75.] Hydroquinone does not bleach the skin, and can only disrupt the synthesis and production of melanin hyperpigmentation. It has been banned in some countries (e.g.
France) because of fears of a cancer risk.
Some concerns about hydroquinone's safety on skin have been expressed, but the research when it comes to topical application indicates negative reactions are minor or a result of using extremely high concentrations or from other skin-lightening agents such as
glucocorticoids or mercury iodine. This is particularly true in Africa where adulterated skin lightening products are commonplace. ["British Journal of Dermatology", March 2003, pages 493-500 and "Critical Reviews in Toxicology", May 1999, pages 283-330.]
Because of hydroquinone's action on the skin, it can be irritant, particularly in higher concentrations of 4% or greater and predictably when combined with tretinoin. Some medications have been created that combine 4% hydroquinone with tretinoin and a form of
cortisone. The cortisone is included as an anti-inflammatory. The negative side effect of repeated application of cortisone is countered by the positive effect of the tretinoin so that it does not cause thinning of skin and damage to collagen. ["Drugs in Dermatology", July-August 2004, pages 377-381.]
Hydroquinone can be an unstable ingredient in cosmetic formulations. When exposed to air or sunlight it can turn a strange shade of brown. Therefore, when you are considering a hydroquinone product, it must be packaged in a non-transparent container that minimizes light and air exposure. Hydroquinone products packaged in jars are not recommended because they become ineffective shortly after opening.
Alternatives to hydroquinone
Some of alternative lighteners are derivatives of hydroquinone. They include
Mitracarpus scaberextract, Uva ursi ( bearberry) extract, Morus bombycis ( mulberry), Morus alba ( white mulberry), and Broussonetia papyrifera ( paper mulberry). All of these contain arbutin(technically known as hydroquinone-beta-D-glucoside), which can inhibit melanin production. Pure forms of arbutin are considered more potent for affecting skin lightening (alpha-arbutin, beta-arbutin, and deoxy-arbutin).
Other options with some amount of research regarding their potential skin lightening abilities are
licoriceextract (specifically glabridin), azelaic acid, and stabilized vitamin C(L-ascorbic acid, ascorbic acid, and magnesium ascorbyl phosphate).
There is also a small amount of research showing oral supplements of
pomegranateextract, ellagic acid, vitamin E, and ferulic acidcan inhibit melanin production. ["Experimental Dermatology", August 2005, pages 601-608; "Bioscience, Biotechnology, and Biochemistry", December 2005, pages 2368-2373; "International Journal of Dermatology", August 2004, pages 604-607; "Journal of Drugs in Dermatology", July-August 2004, pages 377-381; "acial and Plastic Surgery", February 2004, pages 3-9; "Dermatologic Surgery", March 2004, pages 385-388; "Journal of Bioscience and Bioengineering", March 2005, pages 272-276; "Journal of Biological Chemistry", November 7, 2003, pages 44320-44325; "Journal of Agriculture and Food Chemistry", February 2003, pages 1201-1207; "International Journal of Cosmetic Science", August 2000, pages 291-303; and "Anti-Cancer Research", September-October 1999, pages 3769-3774).]
Arbutin is derived from the leaves of bearberry, cranberry, mulberry or blueberry shrubs, and also is present in most types of
pears. It can have melanin-inhibiting properties. ["The Journal of Pharmacology and Experimental Therapeutics", February 1996, pages 765-769.] Concentration protocols have yet to be established for arbutin, meaning it is not known how much arbutin it takes to lighten skin when it is added to a cosmetic formulation. Moreover, there are patents controlling its use for skin lightening. Many cosmetics companies use plant extracts that contain arbutin. There is little to no research showing the plant extract source of arbutin as having any impact on skin, especially not in the tiny amounts used in cosmetics.Fact|date=February 2007
Research has shown that the use of tretinoin (also known as all-trans retinoic acid) can only be somewhat effective in treating skin discolorations. ["Dermatologic Surgery", March 2006, pages 365-371; "Acta Dermato-Venereologica", July 1999, pages 305-310; "International Journal of Dermatology", April 1998, pages 286-292; and "Journal of the American Academy of Dermatology", March 1997, pages S27-S36.]
Alpha hydroxy acids
Alpha hydroxy acids (AHAs) — primarily in the form of lactic acidand glycolic acid— are the most researched forms of AHAs because they have a molecular size that allows effective penetration into the top layers of skin. It is generally assumed that in and of themselves AHAs in concentrations of 4% to 15% are not effective for inhibiting melanin production and will not lighten skin discolorations in that manner. It is believed that their benefit is in helping cell turnover rates and removing unhealthy or abnormal layers of superficial skin cells (exfoliation) where hyperpigmented cells can accumulate. However, other research has shown that lactic and glycolic acids can indeed inhibit melanin production separate from their actions as an exfoliant on skin. ["Experimental Dermatology", January 2003, supplemental. pages 43-50.]
Like laser treatments, alpha hydroxy acid peels (using 50% concentrations or greater) may remove skin discolorations. Only a qualified physician should perform these types of facial peels. ["Dermatologic Surgery", February 2005, pages 149-154; "Journal of Cutaneous Medicine and Surgery", April 2004, pages 97-102; "Cutis", February 2004, supplemental, pages 18-24; "Dermatologic Therapy", June 2004, pages 196-205; and "Dermatological Surgery", June 1999, pages 450-454.]
Kojic acid is a by-product in the fermentation process of malting rice for use in the manufacturing of
sake, the Japanese rice wine. Some research shows kojic acid to be effective for inhibiting melanin production. ["Archives of Pharmacal Research", August 2001, pages 307-311.] However, kojic acid is an unstable ingredient in cosmetic formulations. Upon exposure to air or sunlight it can turn brown and lose its efficacy. Many cosmetic companies use kojic dipalmitate as an alternative because it is more stable in formulations. However, there is no research showing kojic dipalmitate to be as effective as kojic acid, although is it a good antioxidant. Further, some controversial research has suggested that kojic acid may have carcinogenicproperties in large doses. [http://www.isclinical.com/whitepapers/kojic_acid_safety.htm] ["Mutation Research, Genetic Toxicology and Environmental Mutagenesis", June 2005, pages 133-1450 and "Toxicological Sciences", September 2004, pages 43-49.]
Azelaic acid is a component of grains, such as
wheat, rye, and barley. It is applied topically in a cream formulation at a 20% concentration. Azelaic acid is used to treat acne, but there also is research showing it to be effective for skin discolorations. ["International Journal of Dermatology", December 1991, pages 893-895.] Other research also indicates azelaic acid may be an option for inhibiting melanin production. ["Journal of the American Academy of Dermatology", May 2006, supplemental, pages 272-281.]
Magnesium ascorbyl phosphate, L-ascorbic acid, ascorbyl glucosamine, and ascorbic acid are various forms of vitamin C considered stable and effective antioxidants for skin. There are very few studies showing them to have benefit for inhibiting melanin production. The concentrations of these ingredients used in tests were generally high (more than 5%), which is rarely used in cosmetic formulations. ["International Journal of Dermatology", August 2004, page 604; Dermatology, April 2003, pages 316-320; "Journal of the American Academy of Dermatology", January 1996, pages 29-33; http://www.theswisscare.com] .
Glutathione is an effective skin whitener if taken in sufficient dosage.
Both ablative and nonablative lasers can have a profound effect on melasma. However, the results are not always consistent, and problems have been reported (such as hypo- or hyperpigmentation). Laser treatments of this kind are more likely to result in problems for those with darker skin tones. ["Journal of the American Academy of Dermatology", May 2006, supplemental, pages 262-271; "Dermatologic Therapy", January 2001, page 46; "Journal of Cosmetic and Laser Therapy", March 2005, pages 39-43; "Journal of Cutaneous Medicine and Surgery", April 2004, pages 97-102; "Journal of Drugs in Dermatology", November-December 2005, pages 770-774; "Dermatologic Surgery", October 2005, page 1263; and "Lasers in Surgery and Medicine", April 2000, pages 376-379.]
Venetian Ceruse- white lead based cosmetic worn by Elizabeth I of England.
History of cosmetics
Pale (skin tone)
* [http://www.sapnamagazine.com/index.php?option=com_content&task=view&id=121&Itemid=30 "The White Complex"] by Anushay Hossain, "Sapna Magazine" Spring 2008
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