Pharmacologicalor biological activity is an expression describing the beneficial or adverse effects of a drugon living matter. When the drug is a complex chemical mixture, this activity is exerted by the substance's active ingredientor pharmacophorebut can be modified by the other constituents. The main kind of biological activity is a substance's toxicity. Activity is generally dosage-dependent and it is not uncommon to have effects ranging from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the ADMEcriteria.
Whereas a material is considered bioactive if it has interaction with or effect on any cell tissue in the
human body, pharmacological activity is usually taken to describe beneficial effects, i.e. the effects of drug candidates.
In the study of
biomineralisation, bioactivity is often meant as the formation of calcium phosphatedeposits on the surface of objects placed in simulated body fluid, a buffer solutionwith ion content similar to blood.
Lipinski's Rule of Five, describing molecular properties of drugs
QSAR, quantitative structure-affinity relationship
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