Immune complex


Immune complex
Immune Complex Diseases

An immune complex is formed from the integral binding of an antibody to a soluble antigen. The bound antigen acting as a specific epitope, bound to an antibody is referred to as a singular immune complex. After an antigen-antibody reaction, the immune complexes can be subject to any of a number of responses, including complement deposition, opsonization, phagocytosis, or processing by proteases. Red blood cells carrying CR1-receptors on their surface may bind C3b-decorated immune complexes and transport them to phagocytes, mostly in liver and spleen, and return back to the general circulation.

Immune complexes may themselves cause disease when they are deposited in organs, e.g. in certain forms of vasculitis. This is the third form of hypersensitivity in the Gell-Coombs classification, called Type III hypersensitivity.

Immune complex deposition is a prominent feature of several autoimmune diseases, including systemic lupus erythematosus, cryoglobulinemia, rheumatoid arthritis, scleroderma and Sjögren's syndrome.

External links


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • immune complex — n any of various molecular complexes formed in the blood by combination of an antigen and an antibody that tend to accumulate in bodily tissue and are associated with various pathological conditions (as glomerulonephritis, vasculitis, and… …   Medical dictionary

  • immune complex — Multimolecular antibody antigen complexes that may be soluble or insoluble depending upon their size and whether or not complement is present. Immune complexes can be filtered from plasma in the kidney, and the deposition of the complexes gives… …   Dictionary of molecular biology

  • immune complex — (ī mūn kom pleks) The product of an antigen antibody reaction, which may also contain components of the complement system …   Dictionary of microbiology

  • immune complex — an aggregate of an antigen and its specific antibody. [1970 75] * * * …   Universalium

  • immune complex — an aggregate of an antigen and its specific antibody. [1970 75] …   Useful english dictionary

  • immune complex hemolytic anemia — A condition in which the body’s immune system stops red blood cells from forming or causes them to clump together. Immune complex hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL). Also called autoimmune hemolytic …   English dictionary of cancer terms

  • immune complex diseases — Diseases characterized by the presence of immune complexes in body fluids. Hypersensitivity of the Arthus type and serum sickness are examples …   Dictionary of molecular biology

  • immune complex disease — any of a variety of local or systemic diseases caused by the formation of circulating antibody antigen immune complexes and their deposition in tissue, due to activation of complement and to recruitment and activation of leukocytes; see also type …   Medical dictionary

  • immune complex glomerulonephritis — glomerulonephritis due to formation of circulating immune complexes and their deposition in tissue, a type III hypersensitivity reaction, which causes activation of complement and an inflammatory response, leading to activation of leukocytes and… …   Medical dictionary

  • Immune tolerance in pregnancy — or gestational/maternal immune tolerance is the absence of a maternal immune response against the fetus and placenta, which thus may be viewed as unusually successful allografts, since they genetically differ from the mother.[1] In the same way,… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.