pap smear with group of normal cervical cells on left and HPV-infected cells showing features typical of koilocytes: enlarged (x2 or x3) nuclei and hyperchromasia.]

Koilocytes are a type of dysplastic squamous cell found in potentially precancerous cervical lesions. They have the following characteristics:

*Nuclear enlargement (two to three times normal size)
*Irregularity in the nuclear contour (occasionally)
*Perinuclear clearing

Koilocytosis (a.k.a koilocytotic atypia) are cellular changes in which cells appear to have halo nuclei on cytologic examination. Histologic review usually reveals an abnormal lesion composed of intermediate and superficial squamous cells of the vaginal epithelium. Koilocytosis is characteristic of ASC-US (atypical squamous cells - undetermined significance) by cytologists if the degree of koilocytosis appears minute. A more differentiated koilocyte, possessing a more hyperchromatic and enlarged nucleus, and a higher degree of cytoplasmic clearing with a discernible peripheral rim favor an interpretation of low-grade squamous intraepithelial lesion (LSIL). These changes occur in the presence of human papillomavirus, and occasionally can lead to cervical intraepithelial neoplasia, and eventually malignant cancer.

ee Also

Human papillomavirus

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • koilocyte — A squamous cell, often binucleated, showing a perinuclear halo; characteristic of human papillomavirus infection. [G. koilos, hollow, + kytos, cell] * * * koi·lo·cyte kȯi lə .sīt n a vaculoated pyknotic e …   Medical dictionary

  • Human papillomavirus — Taxobox image size = 190px image caption =EM of papillomavirus virus group = i ordo = Unranked familia = Papillomaviridae subdivision ranks = Genera subdivision = Alphapapillomavirus Betapapillomavirus Gammapapillomavirus Mupapillomavirus… …   Wikipedia

  • Wart — For the Nintendo character, see Wart (Nintendo). For toad warts, see parotoid gland. Warts Classification and external resources Warts on the big toe ICD 10 B …   Wikipedia

  • Pap test — Intervention ICD 9 CM 795.00 …   Wikipedia

  • Cervical cancer — Classification and external resources Histopathologic image (H E stain) of carcinoma in situ, stage 0. ICD 10 C …   Wikipedia

  • Genital wart — Genital wart(s) Classification and external resources Severe case of genital warts around the anus ICD 10 A …   Wikipedia

  • Colposcopy — Not to be confused with colonoscopy. Colposcopy Intervention In this diagram, the canal of the cervix (or endocervix) is circled at the base of the womb. The vaginal portion of the cervix projects free into the vagina. The transformation zone …   Wikipedia

  • Plantar wart — Classification and external resources A plantar wart. Striae (fingerprints) go around the lesion. ICD 10 B07 ICD …   Wikipedia

  • Cervical intraepithelial neoplasia — Classification and external resources ICD 10 D06, N87 ICD 9 …   Wikipedia

  • Papanicolaou stain — showing a low grade squamous intraepithelial lesion (LSIL). Pap test. Papanicolaou stain (also Papanicolaou s stain and Pap stain) is a multichromatic staining histological technique developed by George Papanikolaou, the father of cytopathology.… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.