Interleukin 7

Interleukin 7 (IL7) is a hematopoietic growth factor secreted by the stromal cells of the red marrow and thymus capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis (From UniProt IL7_HUMAN).

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. [cite web | title = Entrez Gene: IL7 interleukin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3574| accessdate = ]

References

Further reading

* [http://bloodjournal.hematologylibrary.org/cgi/content/full/99/11/3892 Terry J. Fry and Crystal L. Mackall, "Interleukin-7: from bench to clinic", "Blood," Vol. 99, No. 11, pp. 3892-3904. Review article (1 June 2002)] PBB_Further_reading
citations =
*cite journal | author=Möller P, Böhm M, Czarnetszki BM, Schadendorf D |title=Interleukin-7. Biology and implications for dermatology |journal=Exp. Dermatol. |volume=5 |issue= 3 |pages= 129–37 |year= 1997 |pmid= 8840152 |doi=
*cite journal | author=Appasamy PM |title=Biological and clinical implications of interleukin-7 and lymphopoiesis |journal=Cytokines Cell. Mol. Ther. |volume=5 |issue= 1 |pages= 25–39 |year= 1999 |pmid= 10390077 |doi=
*cite journal | author=Fry TJ, Mackall CL |title=Interleukin-7: from bench to clinic |journal=Blood |volume=99 |issue= 11 |pages= 3892–904 |year= 2002 |pmid= 12010786 |doi=
*cite journal | author=Fry TJ, Mackall CL |title=Interleukin-7 and immunorestoration in HIV: beyond the thymus |journal=J. Hematother. Stem Cell Res. |volume=11 |issue= 5 |pages= 803–7 |year= 2003 |pmid= 12427286 |doi= 10.1089/152581602760404603
*cite journal | author=Al-Rawi MA, Mansel RE, Jiang WG |title=Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours |journal=Histol. Histopathol. |volume=18 |issue= 3 |pages= 911–23 |year= 2004 |pmid= 12792903 |doi=
*cite journal | author=Aspinall R, Henson S, Pido-Lopez J, Ngom PT |title=Interleukin-7: an interleukin for rejuvenating the immune system |journal=Ann. N. Y. Acad. Sci. |volume=1019 |issue= |pages= 116–22 |year= 2004 |pmid= 15247003 |doi= 10.1196/annals.1297.021
*cite journal | author=Snyder KM, Mackall CL, Fry TJ |title=IL-7 in allogeneic transplant: clinical promise and potential pitfalls |journal=Leuk. Lymphoma |volume=47 |issue= 7 |pages= 1222–8 |year= 2007 |pmid= 16923550 |doi= 10.1080/10428190600555876
*cite journal | author=Brunton LL, Lupton SD |title=An STS in the human IL7 gene located at 8q12-13 |journal=Nucleic Acids Res. |volume=18 |issue= 5 |pages= 1315 |year= 1990 |pmid= 2320434 |doi=
*cite journal | author=Lupton SD, Gimpel S, Jerzy R, "et al." |title=Characterization of the human and murine IL-7 genes |journal=J. Immunol. |volume=144 |issue= 9 |pages= 3592–601 |year= 1990 |pmid= 2329282 |doi=
*cite journal | author=Goodwin RG, Lupton S, Schmierer A, "et al." |title=Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 1 |pages= 302–6 |year= 1989 |pmid= 2643102 |doi=
*cite journal | author=Sutherland GR, Baker E, Fernandez KE, "et al." |title=The gene for human interleukin 7 (IL7) is at 8q12-13 |journal=Hum. Genet. |volume=82 |issue= 4 |pages= 371–2 |year= 1989 |pmid= 2786840 |doi=
*cite journal | author=Muegge K, Vila MP, Durum SK |title=Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene |journal=Science |volume=261 |issue= 5117 |pages= 93–5 |year= 1993 |pmid= 7686307 |doi=
*cite journal | author=Watanabe M, Ueno Y, Yajima T, "et al." |title=Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes |journal=J. Clin. Invest. |volume=95 |issue= 6 |pages= 2945–53 |year= 1995 |pmid= 7769137 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Noguchi M, Nakamura Y, Russell SM, "et al." |title=Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor |journal=Science |volume=262 |issue= 5141 |pages= 1877–80 |year= 1994 |pmid= 8266077 |doi=
*cite journal | author=Sica D, Rayman P, Stanley J, "et al." |title=Interleukin 7 enhances the proliferation and effector function of tumor-infiltrating lymphocytes from renal-cell carcinoma |journal=Int. J. Cancer |volume=53 |issue= 6 |pages= 941–7 |year= 1993 |pmid= 8473051 |doi=
*cite journal | author=Kroemer RT, Doughty SW, Robinson AJ, Richards WG |title=Prediction of the three-dimensional structure of human interleukin-7 by homology modeling |journal=Protein Eng. |volume=9 |issue= 6 |pages= 493–8 |year= 1996 |pmid= 8862549 |doi=
*cite journal | author=Kroemer RT, Richards WG |title=Homology modeling study of the human interleukin-7 receptor complex |journal=Protein Eng. |volume=9 |issue= 12 |pages= 1135–42 |year= 1997 |pmid= 9010926 |doi=
*cite journal | author=Kim JH, Loveland JE, Sitz KV, "et al." |title=Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1 |journal=Clin. Exp. Immunol. |volume=108 |issue= 2 |pages= 243–50 |year= 1997 |pmid= 9158092 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Interleukin 6 — (interferon, beta 2) PDB rendering based on 1ALU …   Wikipedia

  • Interleukin-2 — Bändermodell nach PDB  …   Deutsch Wikipedia

  • Interleukin-6 — Bändermodell nach PDB  …   Deutsch Wikipedia

  • Interleukin 10 — Bändermodell nach PDB  …   Deutsch Wikipedia

  • Interleukin 6 — Kristallstruktur Interleukin 6 (kurz: IL 6, synonyme ältere Bezeichnungen: Interferon β2 (IFNB2), B Zell stimulierender Faktor, B Zell Differenzierungs Faktor, Leberzell stimulierender Faktor) gehört zu den Interleukinen (bzw. umfassender zu den… …   Deutsch Wikipedia

  • Interleukin 11 — (IL 11) is a multifunctional cytokine first isolated in 1990 from bone marrow derived stromal cells. It is a key regulator of multiple events in hemtaopoiesis, most notably the stimulation of megakaryocyte maturation.cite journal | author = Paul… …   Wikipedia

  • Interleukin 2 — (IL 2) is an interleukin, a type of cytokine immune system signaling molecule, that is instrumental in the body s natural response to microbial infection and in discriminating between foreign (non self) and self. IL 2 mediates its effects by… …   Wikipedia

  • Interleukin-1β — Vorhandene Strukturdaten: s. UniProt Masse/Länge …   Deutsch Wikipedia

  • Interleukin 9 — Interleukin 9, also known as IL9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.cite web | title = Entrez Gene: IL9 interleukin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Interleukin 8 — (IL 8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL 8 in their storage vesicles, the Weibel Palade bodies [Wolff B, Burns AR, Middleton J, Rot A …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.