Altretamine


Altretamine

drugbox
IUPAC_name = N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine



CAS_number = 645-05-6
ATC_prefix = L01
ATC_suffix = XX03
ATC_supplemental =
PubChem = 2123
DrugBank = APRD00652
C=9 | H=18 | N=6
molecular_weight = 210.28 g/mol
bioavailability =
protein_bound = 94%
metabolism =
elimination_half-life = 4.7-10.2 hours
pregnancy_category =
legal_status =
routes_of_administration =

Altretamine (also hexalen) is a drug that is used to treat refractory ovarian cancer. It is not considered a first-line treatment,cite journal |author=Keldsen N, Havsteen H, Vergote I, Bertelsen K, Jakobsen A |title=Altretamine (hexamethylmelamine) in the treatment of platinum-resistant ovarian cancer: a phase II study |journal=Gynecol. Oncol. |volume=88 |issue=2 |pages=118–22 |year=2003 |pmid=12586589 |doi=10.1016/S0090-8258(02)00103-8] but it can be useful as salvage therapy.cite journal |author=Chan JK, Loizzi V, Manetta A, Berman ML |title=Oral altretamine used as salvage therapy in recurrent ovarian cancer |journal=Gynecol. Oncol. |volume=92 |issue=1 |pages=368–71 |year=2004 |pmid=14751188 |doi=10.1016/j.ygyno.2003.09.017] It also has the advantage of being less toxic than other drugs used for treating refractory ovarian cancer.cite journal |author=Malik IA |title=Altretamine is an effective palliative therapy of patients with recurrent epithelial ovarian cancer |journal=Jpn. J. Clin. Oncol. |volume=31 |issue=2 |pages=69–73 |year=2001 |pmid=11302345 |doi=10.1093/jjco/hye012]

The precise mechanism by which altretamine exerts its anti-cancer effect is unknown, but it is classified by MeSH as an alkylating antineoplastic agent. Hydroxymethylmelamines are the active metabolite.cite journal |author=Damia G, D'Incalci M |title=Clinical pharmacokinetics of altretamine |journal=Clinical pharmacokinetics |volume=28 |issue=6 |pages=439–48 |year=1995 |pmid=7656502 |doi=10.2165/00003088-199528060-00002]

It was approved by the FDA in 1990.

ide effects

Side effects include nausea, vomiting, diarrhea and neurotoxicity.

References

External links

* [http://www.meds-help.com/altretamine/ Altretamine]


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