IUPAC_name = 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane

CAS_number = 28523-86-6
ATC_prefix = N01
ATC_suffix = AB08
ATC_supplemental =
PubChem = 5206
DrugBank = APRD00219
C=4 | H=3 | F=7 | O=1
molecular_weight = 200.055 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_UK = POM
legal_US = Rx-only
legal_status =
routes_of_administration =

Sevoflurane (2,2,2-trifluoro-1- [trifluoromethyl] ethyl fluoromethyl ether), also called fluoromethyl hexafluoroisopropyl ether, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiologyFact|date=April 2008. It is often administered in a mixture of nitrous oxide and oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. Though desflurane has the lowest blood/gas coefficient of the currently used volatile anesthetics, sevoflurane is the preferred agent for mask induction due to its lesser irritation to mucous membranes.

Though it vaporizes readily, it is a liquid at room temperature and is administered via an anesthetic vaporizer attached to an anesthetic machine.

It was introduced into clinical practice initially in Japan in 1990. The rights for sevoflurane in the US and other countries are held by Abbott Laboratories.

Sevoflurane forms at least two degradation products, "Compound A" [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] and "Compound B" [1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane] , on contact with the soda lime in a rebreathing apparatus, which absorbs exhaled carbon dioxide, especially at higher temperatures and when the soda lime is desiccated. Compound A has been shown to cause renal necrosis in rats. In humans, direct histological evidence of renal toxicity has not been demonstrated, although there is dose-related proteinuria, glycosuria and enzymuria. During low-flow anaesthesia, when the lower fresh gas flow leads to decreased flushing of the circuit and increased temperature of the soda lime, Compound A may build up to clinically significant levels. As a result, sevoflurane is sometimes administered with a minimum fresh gas flow of 2 liters per minute, making it a relatively expensive choice for maintaining general anesthesia.

Physical properties

External links

* []

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Sevoflurane — Sévoflurane Sévoflurane Général …   Wikipédia en Français

  • Sévoflurane — Général …   Wikipédia en Français

  • sevoflurane — noun A sweet smelling, non flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia …   Wiktionary

  • sevoflurane — A halogenated ether for inhalation anesthesia. * * * se·vo·flu·rane (se″vo flooґrān) an inhalation anesthetic used for the induction and maintenance of general anesthesia …   Medical dictionary

  • sevoflurane — n. a rapid acting general anaesthetic administered by inhalation, used for inducing and maintaining anaesthesia during surgery …   The new mediacal dictionary

  • 28523-86-6 — Sévoflurane Sévoflurane Général …   Wikipédia en Français

  • C4H3F7O — Sévoflurane Sévoflurane Général …   Wikipédia en Français

  • Desflurane — Systematic (IUPAC) name 2 (difluoromethoxy) 1,1,1,2 tetrafluor …   Wikipedia

  • Methoxyflurane — Methoxyflurane …   Wikipedia

  • 26675-46-7 — Isoflurane Isoflurane Général …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.