IUPAC_name = "N"-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
CAS_number = 29110-47-2
ATC_prefix = C02
ATC_suffix = AC02
PubChem = 3519
DrugBank = APRD00075
C=9 | H=9 | Cl=2 | N=3 | O=1
molecular_weight = 246.093 g/mol
legal_status = Rx-only
Guanfacine (brand name Tenex, and the extended release Intuniv) is a centrally acting
antihypertensiveagent. Guanfacine lowers both systolicand diastolic blood pressureby activating the central nervous system α-2 adrenergic receptors, which results in reduced sympatheticoutflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.
Guanfacine can be used to control
high blood pressure. It works by reducing heart rate and relaxing blood vessels.It is also sometimes prescribed as a treatment for attention-deficit hyperactivity disorder.(In August 2006, the makers of Guanfacine applied to the FDA to use this drug to treat ADHDIn June 2007, the FDAhas issued an approvable letter for Guanfacine for the use of ADHD treatment. [http://www.medicalnewstoday.com/articles/74898.php] ) Another psychiatric use of guanfacine is for treatment of Post-traumatic Stress Disordersymptoms. It can reduce nightmares and flashbacks bringing significant relief to the patient. It is also sometimes used to relieve or reduce symptoms of Chronic Tic Disorder.
Usual: Dizziness, drowsiness, headache, constipation, gas pains, diarrhea, loss of appetite, fatigue, and nasal congestion may occur.
Rare: chest pain, shortness of breath, skin rash, swelling of the hands or feet, blurred vision, yellowing of the eyes or skin.
Others: mental/mood changes, tingling of the hands or feet, dry mouth, impotence, decreased sexual desire, vision changes, taste changes, ringing in the ears, leg cramps.
* [http://www.guanfacine.com/ Guanfacine.com]
*cite journal | url = http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Drug/ACF2FD1.cfm&pub_id=8&article_id=113 | title = Is the use of Guanfacine effective in the treatment of attention deficit/hyperactivity disorder? | author = Shoop SA | journal = U.S. Pharmacist | year = 1998 | volume = 23 | issue = 5
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