Hypertrophic osteopathy is a bone disease secondary to disease in the lungs. It is characterized by new bone formation on the outside of the diaphyses of long bones of the limbs, without destruction of cortical bone. Symptoms include stiffness and warm, firm swelling of the legs, and signs of lung disease such as coughing and difficulty breathing. Hypertrophic osteopathy differs from the condition in humans in that in dogs it is usually caused by lung tumors or infections such as "
Mycobacterium fortuitum" or " Corynebacterium". The most common cause in humans is congenital cyanotic heart disease.cite journal|author=Foster, Wendy K.; Armstrong, Julie A.|title=Hypertrophic osteopathy associated with pulmonary "Eikenella corrodens" infection in a dog|journal=Journal of the American Veterinary Medical Association|year=2006|volume=228|issue=9|pages=1366–1369|url=http://avmajournals.avma.org/doi/abs/10.2460/javma.228.9.1366|accessdate=2006-08-26|doi=10.2460/javma.228.9.1366] Other potential causes in dogs include heartwormdisease, heart disease, and pulmonary abscesses. [cite journal |author=Anderson T, Walker M, Goring R |title=Cardiogenic hypertrophic osteopathy in a dog with a right-to-left shunting patent ductus arteriosus |journal=J Am Vet Med Assoc |volume=224 |issue=9 |pages=1464–6, 1453 |year=2004 |pmid=15124887 |doi=10.2460/javma.2004.224.1464] It has also been associated with nonpulmonary diseases such as renal tumors and rhabdomyosarcomaof the bladder. [cite journal |author=Seaman R, Patton C |title=Treatment of renal nephroblastoma in an adult dog |journal=J Am Anim Hosp Assoc |volume=39 |issue=1 |pages=76–9 |year=2003 |pmid=12549618] At least once it has been caused by congenital megaesophagusin a six year old dog. [cite journal |author=Watrous B, Blumenfeld B |title=Congenital megaesophagus with hypertrophic osteopathy in a 6-year-old dog |journal=Vet Radiol Ultrasound |volume=43 |issue=6 |pages=545–9 |year=2002 |pmid=12502108 |doi=10.1111/j.1740-8261.2002.tb01046.x] Hypertrophic osteopathy is rare in cats. [cite journal |author=Becker T, Perry R, Watson G |title=Regression of hypertrophic osteopathy in a cat after surgical excision of an adrenocortical carcinoma |journal=J Am Anim Hosp Assoc |volume=35 |issue=6 |pages=499–505 |year=1999 |pmid=10580910]
One theory is that hypertrophic osteopathy is caused by increased blood flow to the ends of the legs, overgrowth of
connective tissue, and then new bone formation surrounding the bones. [cite journal |author=Foster W, Armstrong J |title=Hypertrophic osteopathy associated with pulmonary Eikenella corrodens infection in a dog |journal=J Am Vet Med Assoc |volume=228 |issue=9 |pages=1366–9 |year=2006 |pmid=16649940 |doi=10.2460/javma.228.9.1366] This is secondary to nerve stimulation by the lung disease. The condition may reverse if the lung mass is removed or if the vagus nerveis cut on the affected side.
Interestingly, similar bone lesions are seen in dogs that develop
hepatozoonosis, an infectious disease carried by ticks and caused by " Hepatozoon americanum". [cite journal |author=Panciera R, Mathew J, Ewing S, Cummings C, Drost W, Kocan A |title=Skeletal lesions of canine hepatozoonosis caused by Hepatozoon americanum |journal=Vet Pathol |volume=37 |issue=3 |pages=225–30 |year=2000 |pmid=10810986 |doi=10.1354/vp.37-3-225]
Wikimedia Foundation. 2010.
Look at other dictionaries:
hypertrophic osteopathy — a condition in dogs similar to the hypertrophic pulmonary osteoarthropathy of humans; characteristics include hyperostosis of the limbs and later other skeletal regions, sometimes associated with tumors, tuberculosis, or other pulmonary… … Medical dictionary
Hypertrophic pulmonary osteoarthropathy — Classification and external resources Bonescan of a patient with hypertrophic pulmonary osteoarthropathy ICD 10 M … Wikipedia
List of dog diseases — This list of dog diseases is a continuously updated selection of diseases and other conditions found in the dog. Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. Not… … Wikipedia
Periosteal reaction — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 31520 ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = A periosteal reaction is the formation of new bone in response to injury or other stimuli of the… … Wikipedia
acropachia — ac·ro·pach·ia (ak″ro pakґe ə) [acro + pachy + ia] 1. clubbing. 2. hypertrophic osteopathy … Medical dictionary
Bone disease — Classification and external resources ICD 10 M80 M90 ICD 9 … Wikipedia
Osteochondropathy — Classification and external resources ICD 10 M93.9 ICD 9 732 Osteochondropathy refers to a … Wikipedia
ICD-10 Chapter IX: Diseases of the circulatory system — International Statistical Classification of Diseases and Related Health Problems 10th Revision Chapter Blocks Title I A00–B99 Certain infectious and parasitic diseases II C00–D48 Neoplasms III D50–D89 Diseases of the blood and blood forming… … Wikipedia
Cardiovascular disease — Classification and external resources ICD 10 I51.6 ICD 9 429.2 … Wikipedia
Chondropathy — Classification and external resources ICD 10 M91 M94 ICD 9 … Wikipedia