Class I PI 3-kinases
Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.
Class IA PI 3-kinases
Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).
There are three catalytic subunits that are classified as class IA PI 3-kinases:
There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:
- p85α and p85β
- p55α and p55γ
Class IB PI 3-kinases
Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).
The only known class IB PI 3-kinase catalytic subunit is p110γ.
There are two known regulatory subunits for p110γ:
- phosphoinositide 3-kinase
- phosphoinositide 3-kinase inhibitor
- Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment". Endocr. Relat. Cancer 8 (3): 237–48. doi:10.1677/erc.0.0080237. PMID 11566615. http://erc.endocrinology-journals.org/cgi/reprint/8/3/237.
- Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". J. Cell. Sci. 116 (Pt 15): 3037–40. doi:10.1242/jcs.00609. PMID 12829733.
- Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases" ([dead link] – Scholar search). Exp. Cell Res. 253 (1): 239–54. doi:10.1006/excr.1999.4701. PMID 10579926. http://www.ludwig.ucl.ac.uk/cellsig_pdf/VanhaesebroeckB1999c.pdf.
Transferases: phosphorus-containing groups (EC 2.7) 2.7.1-2.7.4:
(PO4)Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD+ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase2.7.2: COOH acceptor
(PO4-nucleoside)RNA nucleotidyltransferaseUridylyltransferaseGlucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferaseGuanylyltransferasemRNA capping enzymeOther
2.7.8: miscellaneousPhosphatidyltransferasesCDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferaseGlycosyl-1-phosphotransferase 2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)see tyrosine kinasessee serine/threonine-specific protein kinases2.7.12: protein-dual-specificitysee serine/threonine-specific protein kinases2.7.13: protein-histidine
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