Flupentixol

Flupentixol
Systematic (IUPAC) name
(EZ)-2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral, IM
Pharmacokinetic data
Half-life 19-39 hours
Identifiers
CAS number 2709-56-0 YesY
ATC code N05AF01
PubChem CID 5281881
DrugBank APRD00388
ChemSpider 4445173 YesY
UNII FA0UYH6QUO YesY
KEGG D01044 YesY
ChEMBL CHEMBL42055 N
Chemical data
Formula C23H25F3N2OS
Mol. mass 434.5219 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol, is a typical antipsychotic drug of the thioxanthene class. In addition to single drug preparations, it is also available as Anxiset, Deanxit, Mixit, a combination product containing both melitracen and flupentixol.

Contents

Indications

Flupentixol's main use is as a long-acting injection given two or three times weekly to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness.

Flupentixol is also used in low doses as an antidepressant.[1][2][3][4][5][6]

Pharmacology

Flupentixol acts as an antagonist at various dopamine (D1-D5), serotonin (5-HT2), adrenaline (α1), and histamine (H1) receptors,[7] without affecting the muscarinic acetylcholine receptors.[8]

Its antipsychotic effects are likely caused by D2 and/or 5-HT2A antagonism, whereas its antidepressant effects at lower doses may be mediated by preferential D2/D3 autoreceptor blockade, resulting in increased postsynaptic activation.

Side effects

The side effects of flupentixol are similar to most other typical antipsychotics, namely extrapyramidal symptoms of akathisia, muscle tremors, and rigidity and antihistamine effects like sedation and somnolence. However, it lacks anticholinergic adverse effects. But seizures have been reported in some users, and long-term use may even inflict epilepsy on some takers."Flupentixol\Antipsychotic Drugs\Psychotherapeutic Drugs". http://psychotherapeuticdrugs.com/index.php/antipsychotic-drugs/flupentixol. 

See also

References

  1. ^ Robertson MM, Trimble MR (May 1981). "The antidepressant action of flupenthixol". The Practitioner 225 (1355): 761–3. PMID 7291129. 
  2. ^ Pöldinger W, Sieberns S (1983). "Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate". Neuropsychobiology 10 (2-3): 131–6. PMID 6674820. 
  3. ^ Johnson DA (January 1979). "A double-blind comparison of flupenthixol, nortriptyline and diazepam in neurotic depression". Acta Psychiatrica Scandinavica 59 (1): 1–8. PMID 369298. 
  4. ^ Young JP, Hughes WC, Lader MH (May 1976). "A controlled comparison of flupenthixol and amitriptyline in depressed outpatients". British Medical Journal 1 (6018): 1116–8. PMC 1639983. PMID 773506. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1639983. 
  5. ^ Fujiwara J, Ishino H, Baba O, Hanaoka M, Sasaki K (August 1976). "Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients". Acta Psychiatrica Scandinavica 54 (2): 99–105. PMID 961463. 
  6. ^ Tam W, Young JP, John G, Lader MH (March 1982). "A controlled comparison of flupenthixol decanoate injections and oral amitriptyline in depressed out-patients". The British Journal of Psychiatry : the Journal of Mental Science 140: 287–91. PMID 7093597. 
  7. ^ "PDSP Database - UNC". http://pdsp.med.unc.edu/pdsp.php. 
  8. ^ Golds PR, Przyslo FR, Strange PG (March 1980). "The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors". British Journal of Pharmacology 68 (3): 541–9. PMC 2044199. PMID 7052344. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2044199. 



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Look at other dictionaries:

  • Flupentixol — Général Nom IUPAC (E,Z) 2 [4 [3 [2 (trifluoromethyl)thioxanthen 9 ylidene] propyl]piperazin 1 yl]ethanol …   Wikipédia en Français

  • Flupentixol — Strukturformel (Z) Form (= cis Form) oben und (E) Form (= trans Form) unten Allgemeines …   Deutsch Wikipedia

  • flupentixol — noun A typical antipsychotic drug of the thioxanthenes. Syn: flupenthixol …   Wiktionary

  • flupentixol — A neuroleptic. * * * n. a thioxanthene antipsychotic drug used to treat schizophrenia and other psychoses. It is administered by mouth and by injection. Possible side effects include sedation and involuntary movements. Trade names: Depixol,… …   Medical dictionary

  • flupentixol — flupenthixol; n. a thioxanthene antipsychotic drug used to treat schizophrenia and other psychoses. It is administered by mouth and by injection. Possible side effects include abnormal involuntary movements (see extrapyramidal effects). Trade… …   The new mediacal dictionary

  • Flupentixol/melitracen — Combination of Flupentixol Typical antipsychotic Melitracen Tricyclic antidepressant Clinical data Pregnancy cat.  ? Legal status ℞ …   Wikipedia

  • flupenthixol — flupentixol …   The new mediacal dictionary

  • 2709-56-0 — Flupentixol Flupentixol Général Nom IUPAC (E,Z) 2 [4 [3 [2 (trifluoromethyl)thioxanthen 9 ylidene] propyl]piperazin 1 yl]ethanol …   Wikipédia en Français

  • Fluanxol — Flupentixol Flupentixol Général Nom IUPAC (E,Z) 2 [4 [3 [2 (trifluoromethyl)thioxanthen 9 ylidene] propyl]piperazin 1 yl]ethanol …   Wikipédia en Français

  • Fluanxol — Strukturformel (Z) Form (= cis Form) oben und (E) Form (= trans Form) unten Allgemeines Freiname …   Deutsch Wikipedia


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