AIDS denialism

AIDS denialism refers to the views of a loosely connected group of individuals and organizations who deny that the human immunodeficiency virus (HIV) is the cause of acquired immune deficiency syndrome (AIDS). HIV/AIDS denialists prefer the terms "rethinker" or "dissident". Some denialist groups reject the existence of HIV, while others accept that HIV exists but argue that it is a harmless passenger virus and not the cause of AIDS.

The causative role of HIV in the development of AIDS has been established and is the subject of scientific consensus. Denialist arguments are considered to be the result of cherry-picking and misrepresentation of predominantly outdated scientific data,cite journal |author= |title=Denying science |journal=Nat. Med. |volume=12 |issue=4 |pages=369 |year=2006 |pmid=16598265 |doi=10.1038/nm0406-369|quote=To support their ideas, some AIDS denialists have also misappropriated a scientific review in "Nature Medicine" which opens with this reasonable statement: "Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1 infection is pathogenic is still debated."] with the potential to endanger public health by dissuading people from using proven treatments. [cite journal | author = Watson J. | title = Scientists, activists sue South Africa's AIDS 'denialists' | journal = Nat Med. | volume = 12| issue = 1 | pages = 6| year = 2006 | pmid = 16397537 | doi = 10.1038/nm0106-6a] [ [http://www.guardian.co.uk/international/story/0,,1483792,00.html "Discredited doctor's 'cure' for Aids ignites life-and-death struggle in South Africa"] , by Sarah Boseley. Published in "The Guardian" on May 14, 2005. Accessed 9 Feb 2007.] PDFlink| [http://www.sciencemag.org/feature/data/cohen/266-5191-1642a.pdf The Duesberg Phenomenon] , by Jon Cohen. "Science" (1994) 266:5191, pp. 1642–1644. PMID 7992043.] [http://www.niaid.nih.gov/Factsheets/evidhiv.htm The Evidence that HIV Causes AIDS] : a fact sheet from the National Institute of Allergy and Infectious Disease. Accessed February 29, 2008.] cite journal |author= ,|title=The Durban Declaration |journal=Nature |volume=406 |issue=6791 |pages=15–6 |year=2000 |pmid=10894520|doi=10.1038/35017662 — full text available [http://www.nature.com/nature/journal/v406/n6791/full/406015a0.html here] .] With the rejection of these arguments by the scientific community, AIDS denialist material is currently spread largely through the Internet.

Timeline

*1983: A group of scientists and doctors at the Pasteur Institute in France, led by Luc Montagnier, discovers a new virus in a patient with signs and symptoms that often precede AIDS. [cite journal |author=Barré-Sinoussi F, Chermann J, Rey F, Nugeyre M, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vézinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L |title=Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) |journal=Science |volume=220 |issue=4599 |pages=868–71 |year=1983 |pmid=6189183 |doi=10.1126/science.6189183] They name their discovery lymphadenopathy-associated virus, or LAV, and send samples to Robert Gallo's team in the United States.
*1984: On April 23, at a Washington press conference held after the relevant scientific publications have been peer reviewed and slated for publication in "Science", Margaret Heckler, Secretary of Health and Human Services, announces that Gallo and his co-workers have discovered a virus that is the "probable" cause of AIDS. This virus is initially named HTLV-III. [cite journal |author=Sarngadharan MG, DeVico AL, Bruch L, Schüpbach J, Gallo RC |title=HTLV-III: the etiologic agent of AIDS |journal=Int. Symp. Princess Takamatsu Cancer Res. Fund |volume=15 |issue= |pages=301–8 |year=1984 |pmid=6100648 |doi= |url=]
*1984: Casper Schmidt responds to Gallo's papers by writing "The Group-Fantasy Origins of AIDS", which is published by the "Journal of Psychohistory". [cite journal | author = Schmidt C | title = The group-fantasy origins of AIDS | journal = J Psychohist | volume = 12 | issue = 1 | pages = 37–78 | year = 1984 | pmid = 11611586] He posits that AIDS is an example of "epidemic hysteria" in which groups of people are subconsciously acting out social conflicts, and compares it to documented cases of epidemic hysteria in the past which were mistakenly thought to be infectious. Schmidt himself died of AIDS in 1994. [ [http://www.aidstruth.org/aids-denialists-who-have-died.php AIDS Denialists Who Have Died] , from aidstruth.org. Accessed July 14, 2007.]
*1986: The viruses discovered by Montagnier and Gallo, having been found to be genetically indistinguishable, are renamed HIV. [cite journal |author=Coffin J, Haase A, Levy J, Montagnier L, Oroszlan S, Teich N, Temin H, Toyoshima K, Varmus H, Vogt P |title=What to call the AIDS virus? |journal=Nature |volume=321 |issue=6065 |pages=10 |year= 1986|pmid=3010128 |doi=10.1038/321010a0]
*1987: Peter Duesberg questions the HIV theory of AIDS for the first time in his paper "Retroviruses as Carcinogens and Pathogens: Expectations and Reality", published in the journal "Cancer Research".cite journal | author = Duesberg P | title = Retroviruses as carcinogens and pathogens: expectations and reality | journal = Cancer Res | volume = 47 | issue = 5 | pages = 1199–220 | year = 1987 | pmid = 3028606] This publication coincides with the start of major public health campaigns and the promotion of AZT as a treatment.
*1988: A panel of the Institute of Medicine of the United States National Academy of Sciences finds that "the evidence that HIV causes AIDS is scientifically conclusive." [http://books.nap.edu/openbook.php?record_id=771&page=2 Confronting AIDS: Update 1988] , a report from the Institute of Medicine of the United States National Academy of Sciences, published in 1988. On page 2 of the Executive Summary, the panel writes that "…the evidence that HIV causes AIDS is scientifically conclusive."]
* 1988 Science publishes, in the same issue, Blattner, Gallo, and Temin's [http://www.ncbi.nlm.nih.gov/pubmed/3399881?ordinalpos=46&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "HIV causes AIDS"] , and Peter Duesberg's [http://www.ncbi.nlm.nih.gov/pubmed/3399880?ordinalpos=48&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "HIV is not the cause of AIDS"] .
* 1988: A group of denialists based in Perth, Australia ("Perth Group"), led by Eleni Papadopulos-Eleopulos, publishes in the non-peer-reviewed journal "Medical Hypotheses" their first article questioning aspects of HIV/AIDS research. [cite journal | author = Papadopulos-Eleopulos E | title = Reappraisal of AIDS — is the oxidation induced by the risk factors the primary cause? | journal = Med Hypotheses | volume = 25 | issue = 3 | pages = 151–62 | year = 1988 | pmid = 3285143 | doi = 10.1016/0306-9877(88)90053-9] They conclude that there is "no compelling reason for preferring the viral hypothesis of AIDS to one based on the activity of oxidising agents."
* 1989. Duesberg exercises his right, as a member of the National Academy of Sciences, to publish his arguments in "Proceedings of the National Academy of Sciences" (PNAS) without peer review. The editor of PNAS initially resists, but ultimately allows Duesberg to publish, saying: "If you wish to make these unsupported, vague, and prejudicial statements in print, so be it. But I cannot see how this would be convincing to any scientifically trained reader."
* 1990: Robert Root-Bernstein publishes his first peer-reviewed article detailing his objections to the mainstream view of AIDS and HIV, entitled "Do we know the cause(s) of AIDS?" [cite journal | author = Root-Bernstein R | title = Do we know the cause(s) of AIDS? | journal = Perspect Biol Med | volume = 33 | issue = 4 | pages = 480–500 | year = 1990 | pmid = 2216658] In it, he questions both the mainstream view and the dissident view as potentially inaccurate.
*1991: The Group for the Scientific Reappraisal of the HIV-AIDS Hypothesis, comprised of twelve scientists, doctors, and activists, submits a short letter to various journals; the letter is rejected. Another similar letter would be published 4 years later in the journal "Science". [cite journal | author = Baumann E, Bethell T, Bialy H, Duesberg P, Farber C, Geshekter C, Johnson P, Maver R, Schoch R, Stewart G | title = AIDS proposal. Group for the Scientific Reappraisal of the HIV/AIDS Hypothesis | journal = Science | volume = 267 | issue = 5200 | pages = 945–6 | year = 1995 | pmid = 7863335]
*1993: Nature publishes an editorial by John Maddox titled [http://www.ncbi.nlm.nih.gov/pubmed/8483492?ordinalpos=88&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "Has Duesberg a right of reply?". 1993] . Maddox answers the titular question with a "no." According to Duesberg, the full-page editorial is prompted by Duesberg's request for additional data about the article [http://www.ncbi.nlm.nih.gov/pubmed/8095697?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "Does drug use cause AIDS?"] , which claims that the Duesberg hypothesis is wrong. Maddox accuses Duesberg of asking "unanswerable rhetorical questions" [ ["Inventing the AIDS virus", by Peter Duesberg. ISBN 0895263998 ,Page 401] ]
* 1993: The Perth group publishes at "Biotechnology" the article [http://www.ncbi.nlm.nih.gov/pubmed/7763673?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "Is a positive western blot proof of HIV infection?"] . The Group asked for a reappraisal of the Western Blot test used to detect the HIV. They allege that the test is not standardized, non-reproducible, and of unknown specifity, due to an alleged lack of use of a gold standard in the development of the test.
*1994, 28 October: Robert Willner, a physician whose medical license was revoked for, among other things, treating an AIDS patient with ozone therapy, publicly jabs his finger with blood he says is from an HIV-infected patient. Willner dies the following year of a heart attack.cite web
last =Bugl
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title =The Rise of HIV/AIDS
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publisher = Department of Mathematics, University of Hartford
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*1995: The denialist group Continuum places an advertisement in "The Pink Paper" offering a £1,000 reward to "the first person finding one scientific paper establishing actual isolation of HIV" (according to their specific set of rules). [http://www.virusmyth.net/aids/news/ekisolation.htm Isolated facts about HIV] A Response to Claims by AIDS Dissidents That HIV Doesn't Exist by Edward King]
*1996: Various scientists, including Duesberg, dismiss the Continuum challenge, asserting that HIV doubtlessly exists.
*1996:The British Medical Journal publishes [http://www.ncbi.nlm.nih.gov/pubmed/8563584?ordinalpos=27&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "Response: arguments contradict the "foreign protein-zidovudine" hypothesis"] as a response to a petition by Peter Duesberg: "In 1991 Duesberg challenged researchers…We and Darby et al have provided that evidence". The paper argued that Duesberg was wrong regarding the cause of AIDS in haemophiliacs.
* In 1997 the Perth Group publishes [http://www.ncbi.nlm.nih.gov/pubmed/9327197?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "HIV antibodies: further questions and a plea for clarification". 1997] , followed in 1998 by [http://www.ncbi.nlm.nih.gov/pubmed/9787984?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "HIV antibody tests and viral load — more unanswered questions and a further plea for clarification"] . The group hypothesized that the production of antibodies recognizing HIV proteins can be caused by allogenic stimuli and autoimmune disorders, questioning the existence of HIV based upon this speculation. They repeated this argument in a 2006 article [http://www.ncbi.nlm.nih.gov/pubmed/16712545?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "No proof HIV antibodies are caused by a retroviral infection."]
*1998: Valerie Emerson, of Bangor, Maine, prevails in court in Maine for her right to refuse to give AZT to her 4-year-old son Nikolas Emerson, after she witnessed the death of her daughter Tia, who died at the age of 3 in 1996. [ [http://query.nytimes.com/gst/fullpage.html?res=9800EFD61530F933A1575AC0A96E958260&n=Top/News/Health/Diseases,%20Conditions,%20and%20Health%20Topics/AIDS Boy Is Healthy Without Drug For H.I.V., Mother Says – New York Times ] ] Nikolas Emerson died eight years later. [ [http://www.boston.com/news/globe/obituaries/articles/2006/03/10/nikolas_emerson_11_case_led_to_legal_fight_over_hiv/ Nikolas Emerson, 11; case led to legal fight over HIV – The Boston Globe ] ]
*2000: South Africa's President, Thabo Mbeki, invites several HIV/AIDS denialists to join his Presidential AIDS Advisory Panel. [http://www.villagevoice.com/news/0027,schoofs2,16283,1.html "Debating the Obvious: Inside the South African Government's Controversial AIDS Panel"] , by Mark Schoofs. Published in the "Village Voice", 5–11 July 2000. Accessed 26 Feb 2007.] The scientific community responds with the Durban declaration, a document affirming that HIV causes AIDS, signed by over 5,000 scientists and physicians.
*2006: Celia Farber, a journalist and prominent AIDS denialist, publishes an essay in the March issue of "Harper's" entitled "Out of Control: AIDS and the Corruption of Medical Science", in which she summarizes a number of arguments for AIDS denialism and alleges incompetence, conspiracy, and fraud on the part of the medical community. [http://www.harpers.org/OutOfControl.html "Out of Control: AIDS and the Corruption of Medical Science"] , by Celia Farber. Published in "Harper's", March 2006. Accessed 27 Feb 2007.] Leading scientists and AIDS activists extensively criticized the article as inaccurate, misleading, and poorly fact-checked. [ [http://www.nytimes.com/2006/03/13/business/media/13harpers.html An Article in Harper's Ignites a Controversy Over H.I.V.] , by Lia Miller. Published in the "New York Times" on March 13, 2006, accessed April 25, 2008.]
*2007: Eleni Papadopulos-Eleopulos and Valendar Francis Turner testify at an appeals hearing for Andre Chad Parenzee, stating that HIV cannot be transmitted by heterosexual sex. The judge concluded: "I reject the evidence of Ms Papadopulos-Eleopulos and Dr Turner. I conclude…that they are not qualified to give expert opinions" [ [http://www.brisbanetimes.com.au/news/national/shadow-of-doubters/2007/05/04/1177788403414.html?page=fullpage Brisbane Times "Shadow of doubters"] ]

The AIDS denialist community

People critical of the scientific consensus on AIDS include HIV-positive persons, government employees, scientists, doctors, and activists in several countries. One of the most famous and influential AIDS denialist scientists is Peter Duesberg, professor of molecular and cell biology at the University of California, Berkeley, who has been contesting the mainstream view of AIDS causation since 1987. Other scientists associated with AIDS denialism include biochemists David Rasnick and Harvey Bialy. Kary Mullis, who was awarded a Nobel Prize for his role in the development of PCR, has expressed sympathy for dissident theories. ["Dancing Naked in the Mind Field" by Kary Mullis. [http://www.virusmyth.net/aids/data/kmdancing.htm Chapter 18 & 19.] Excerpt re-printed in Penthouse Magazine September 1998.]

Other notable AIDS denialists include Australian academic ethicist Hiram Caton, the late mathematician Serge Lang, [ [http://www.nytimes.com/2005/09/25/national/25lang.html?_r=1&ei=5088&en=81b37e507db355b7 "Serge Lang, 78, a Gadfly and Mathematical Theorist, Dies" The New York Times] ] Professor Emeritus of Chemistry & Science Studies at Virginia Tech Henry Bauer, journalist Celia Farber and activist Christine Maggiore.

Nate Mendel, bassist with the rock band Foo Fighters, expressed support for AIDS dissident ideas and organized a benefit concert in January 2000 for the AIDS denialist organization Alive & Well AIDS Alternatives. [ [http://www.motherjones.com/news/feature/2000/02/foo.html "Foo Fighters, HIV Deniers", Mother Jones magazine, published 25 February 2000.] Accessed 21 Oct 2006.] The Foo Fighters no longer list Alive & Well AIDS Alternatives among the causes they support. [ [http://www.foofighters.com/community] Accessed 25 April 2008.]

Organizations of AIDS denialists include the Perth Group (started by several Australian denialists in Perth, Western Australia), and the Group for the Scientific Reappraisal of the HIV-AIDS Hypothesis.

AIDS denialism has received some support from some political conservatives in the United States. Duesberg's work has been published by the conservative Heritage Foundation and Regnery Press, as has Tom Bethell's book "The Politically Incorrect Guide to Science", which endorsed AIDS denialism. Phillip E. Johnson has accused the Centers for Disease Control of "fraud" in relation to HIV/AIDS.cite web |url=http://www.virusmyth.com/aids/hiv/pjcdc.htm |title=HIV & AIDS - Statement About CDC Fraud |accessdate=2008-03-18 |format= |work=] Describing the political aspects of the AIDS denialism movement, Steven Epstein wrote in "Impure Science" that "…the appeal of Duesberg's views to conservatives—certainly including those with little sympathy for the gay movement—cannot be denied."p. 158 Paleolibertarian "anti-state/pro-market" blog LewRockwell.com has published articles supportive of AIDS denialism. [ [http://www.google.com/custom?hl=en&cof=L%3Ahttp%3A%2F%2Fwww.lewrockwell.com%2Flewroc1a.gif%3BLH%3A93%3BLW%3A500%3B&domains=lewrockwell.com&q=aids+hiv&btnG=Search&sitesearch=lewrockwell.com Search at lewrockwell.com about the issue] ]

Former dissidents

Several prominent scientists who once voiced doubts about HIV/AIDS science have since changed their views and accepted the idea that HIV plays a role in causing AIDS, in response to an accumulation of newer studies and data. [ [http://www.aegis.com/topics/mdelaney.html "HIV, AIDS, and the Distortion of Science.] By Martin Delaney. Accessed 1 Dec 2006.] Robert Root-Bernstein, author of "Rethinking AIDS: The Tragic Cost of Premature Consensus" and formerly a critic of the causative role of HIV in AIDS, has since distanced himself from the AIDS denialist movement, saying, "Both the camp that says HIV is a pussycat and the people who claim AIDS is all HIV are wrong… The denialists make claims that are clearly inconsistent with existing studies. When I check the existing studies, I don’t agree with the interpretation of the data, or, worse, I can’t find the studies [at all] ." [http://www.poz.com/articles/451_2788.shtml "Dead Certain?"] by Bob Lederer. Published in POZ magazine April 2006. Accessed 31 Oct 2006.]

Joseph Sonnabend, who until the late 1990s regarded the issue of AIDS causation as unresolved, has reconsidered in light of the success of newer antiretroviral drugs, stating, "The evidence now strongly supports a role for HIV… Drugs that can save your life can also under different circumstances kill you. This is a distinction that denialists do not seem to understand." Sonnabend has also criticized AIDS denialists for falsely implying that he supports their position, saying:

Both Sonnabend and Root-Bernstein now favor a less controversial hypothesis, suggesting that cofactors in addition to HIV are necessary to cause AIDS.

Walter Gilbert, winner of the 1980 Nobel Prize in Chemistry, once expressed skepticism about the role of HIV in AIDS. Like Sonnabend, he has since changed his mind in response to the effectiveness of antiretroviral treatment. [http://www.aidstruth.org/Nobel-Denial.pdf Nobel Denial?] , Ken Witwer, June 2007. Accessed 1 May 2008: "Walter Gilbert has long been named by the denialist community as one of “its” Nobelists. But if Walter Gilbert was ever a denialist, does he remain so today? Apparently not: [http://momentofscience.blogspot.com/2006/07/well-someone-has-to-do-it.html correspondence] between Walter Gilbert and Richard Jefferys was published on the Internet in 2006, demonstrating that, whatever Gilbert once thought about HIV, he now recognizes the virus as the cause of AIDS."]

As of June 2008, denialist websites continue to claim that Root-Bernstein, Sonnabend [ [http://www.virusmyth.com/aids/whistleblowers.htm virusmyth.com "Whistle Blowers"] , Accessed 1 May 2008 ] and Gilbert doubt the role of HIV in AIDS. [ [http://www.aras.ab.ca/rethinkers.htm "List of Rethinkers"] : List of people who are claimed to subscribe to AIDS denialist beliefs; some of the listed individuals did not sign the list or have since changed their minds. Accessed 1 May 2008.] A former denialist wrote in the "Journal of Medical Ethics" in 2004:

Death of HIV-positive denialists

In 2007, aidstruth.org, a website run by HIV researchers to counter denialist claims, [cite journal |author=Cohen J |title=HIV/AIDS. AIDSTruth.org Web site takes aim at 'denialists' |journal=Science |volume=316 |issue=5831 |pages=1554 |year=2007 |pmid=17569834 |doi=10.1126/science.316.5831.1554] published a partial list of AIDS denialists who had died of apparently AIDS-related causes. For example, the magazine "Continuum", run by HIV-positive denialists, shut down when its editors all died of AIDS-related causes. In every case, the AIDS denialist community attributed the deaths to unknown causes, secret drug use, or stress rather than HIV/AIDS. [ [http://www.aidstruth.org/aids-denialists-who-have-died.php AIDS Denialists Who Have Died] , from aidstruth.org. Accessed July 19, 2007.] Similarly, several HIV-positive former dissidents have reported being ostracized by the AIDS-denialist community after they developed AIDS and decided to pursue effective antiretroviral treatment. [ [http://www.aegis.org/news/misc/2000/bg000201.html Bad science: They once thought HIV was harmless. Now, they say, AIDS has forced them to reconsider] , by Bruce Mirken. Published in the "San Francisco Bay Guardian" on February 2, 2000; accessed May 9, 2008.]

AIDS denialists claims

Although members of the AIDS denialist community are united by their disagreement with the concept that HIV is the cause of AIDS, the specific positions taken by various groups differ.

Denialist arguments have centered around claims that HIV does not exist or has not been adequately isolated, [Turner V. (1999) [http://www.virusmyth.com/aids/hiv/vtcorweiss.htm E-Mail Correspondence Between Val Turner and Robin Weiss] ] that the virus does not fulfill Koch's postulates,cite journal |author=Duesberg P |title=Human immunodeficiency virus and acquired immunodeficiency syndrome: correlation but not causation |journal=Proc Natl Acad Sci U S A |volume=86 |issue=3 |pages=755–64 |year=1989 |pmid=2644642 |doi=10.1073/pnas.86.3.755] that HIV testing is inaccurate, [cite journal |author=Papadopulos-Eleopulos E, Turner V, Papadimitriou J |title=Is a positive western blot proof of HIV infection? |journal=Biotechnology (N Y) |volume=11 |issue=6 |pages=696–707 |year=1993 |pmid=7763673 |doi=10.1038/nbt0693-696] or that antibodies to HIV neutralize the virus and render it harmless. [ [http://www.healtoronto.com/10reasons.html HealToronto.com, dissident website, claiming to provide 10 reasons why HIV cannot cause AIDS] . Accessed 28 September 2006.] Suggested alternative causes of AIDS include recreational drugs, malnutrition and the very antiretroviral drugs used to treat the syndrome. [cite journal |author=Duesberg P, Koehnlein C, Rasnick D |title=The chemical bases of the various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition |journal=J Biosci |volume=28 |issue=4 |pages=383–412 |year=2003 |pmid=12799487 |doi=10.1007/BF02705115] Denialists claim that these drugs are exceptionally toxic and cause the very symptoms they are supposed to delay. [ [http://www.duesberg.com/articles/azt.html Articles on AZT hosted by Peter Duesberg] ] To support this claim, they cite two studies from the late 1980s whose authors said they found it difficult to distinguish adverse events possibly associated with administration of Retrovir (AZT) from underlying signs of HIV disease or intercurrent illnesses. [ [http://www.virusmyth.net/aids/data/pdr-azt.htm Virusmyth.net: HIV & AIDS – AZT, Zidovudine, Retrovir – Product Information] ]

Such claims have been examined extensively in the peer-reviewed medical and scientific literature; a scientific consensus has arisen that denialist claims have been convincingly disproved, and that HIV does indeed cause AIDS. [http://www.niaid.nih.gov/Factsheets/evidhiv.htm NIAID Fact Sheet: The Evidence that HIV Causes AIDS] . Accessed via National Institutes of Health website on 24 Oct 2006.] [http://www.cdc.gov/hiv/resources/factsheets/index.htm Fact Sheets on HIV/AIDS] , from the Centers for Disease Control. Accessed 26 Feb 2007.] [ [http://www.who.int/hiv/en/ World Health Organization HIV and AIDS Programme] , from the World Health Organization website. Accessed 26 Feb 2007.] In the cases cited by Duesberg where HIV "cannot be isolated", PCR or other techniques demonstrate the presence of the virus, [cite journal | author = O'Brien SJ, Goedert JJ. | title = HIV causes AIDS: Koch's postulates fulfilled| journal = Curr Opin Immunol.| volume = 8 | issue = | pages = 613–618 | year = 1996 | pmid = 8902385 | doi = 10.1016/S0952-7915(96)80075-6] and many denialist claims of HIV test inaccuracy result from an incorrect or outdated understanding of how HIV antibody testing is performed and interpreted. [ [http://www.kaisernetwork.org/health_cast/uploaded_files/081306_ias_sat_journalism.pdf HIV Science and Responsible Journalism] ] [ [http://www.aidstruth.org/howimmunoassayswork.php How Immunoassays Work: The Curious Case of AIDS Denialist Roberto Giraldo and his Ignorance of the Basics] ]

Early denialist arguments held that the HIV/AIDS paradigm was flawed because it had not led to effective treatments. However, the introduction of highly active antiretroviral therapy in the mid-1990s and dramatic improvements in survival of HIV/AIDS patients reversed this argument, as these treatments were based directly on the HIV/AIDS paradigm.Major studies confirming the benefits and effectiveness of modern anti-HIV therapy include, but are not limited to:
*cite journal |author=Lima V, Hogg R, Harrigan P, Moore D, Yip B, Wood E, Montaner J |title=Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy |journal=AIDS |volume=21 |issue=6 |pages=685–92 |year=2007 |pmid=17413689 |doi=10.1097/QAD.0b013e32802ef30c
*cite journal |author=Jordan R, Gold L, Cummins C, Hyde C |title=Systematic review and meta-analysis of evidence for increasing numbers of drugs in antiretroviral combination therapy |journal=BMJ |volume=324 |issue=7340 |pages=757 |year=2002 |pmid=11923157 |doi=10.1136/bmj.324.7340.757 — [http://bmj.bmjjournals.com/cgi/content/full/324/7340/757 full text]
*cite journal |author=Ivers L, Kendrick D, Doucette K |title=Efficacy of antiretroviral therapy programs in resource-poor settings: a meta-analysis of the published literature |journal=Clin Infect Dis |volume=41 |issue=2 |pages=217–24 |year=2005 |pmid=15983918 |doi=10.1086/431199
*cite journal | author = Mocroft A, Ledergerber B, Katlama C, Kirk O, Reiss P, d'Arminio Monforte A, Knysz B, Dietrich M, Phillips A, Lundgren J | title = Decline in the AIDS and death rates in the EuroSIDA study: an observational study | journal = Lancet | volume = 362 | issue = 9377 | pages = 22–9 | year = 2003 | pmid = 12853195 | doi = 10.1016/S0140-6736(03)13802-0
*cite journal | author = Sterne J, Hernán M, Ledergerber B, Tilling K, Weber R, Sendi P, Rickenbach M, Robins J, Egger M | title = Long-term effectiveness of potent antiretroviral therapy in preventing AIDS and death: a prospective cohort study | journal = Lancet | volume = 366 | issue = 9483 | pages = 378–84 | year = 2005| pmid = 16054937 | doi = 10.1016/S0140-6736(05)67022-5] The development of effective anti-HIV therapy has been a major factor in convincing some denialist scientists to accept the causative role of HIV in AIDS.

Impact beyond the scientific community

AIDS denialist claims have failed to attract support in the scientific community, where the evidence for the causative role of HIV in AIDS is considered conclusive. However, the AIDS denialist movement has had a significant impact outside of scientific spheres, making the debate a civil and political as well as a public health issue.

Impact in North America and Europe

Skepticism about HIV as the cause of AIDS began almost immediately after the discovery of HIV was announced. One of the earliest prominent skeptics was the journalist John Lauritsen, who argued in his writings for "The New York Native" that AIDS was in fact caused by amyl nitrite poppers, and that the government had conspired to hide the truth. [ [http://www.virusmyth.net/aids/data2/jlbio.htm Biography of John Lauritsen] at Virusmyth.com, a dissident website. Accessed 7 Sept 2006.]

In the scientific literature

The publication of Peter Duesberg's first AIDS paper in 1987 provided further support for denialist claims. Shortly afterwards, the journal "Science" reported that Duesberg's remarks had won him "a large amount of media attention, particularly in the gay press where he is something of a hero." [Booth W. (1988) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=3281251 A rebel without a cause of AIDS] . "Science" 239(4847), 1485-8 PMID 3281251] However, Duesberg's support in the gay community dried up as he made a series of statements perceived as homophobic; in an interview with the "Village Voice" in 1988, Duesberg stated his belief that the AIDS epidemic was "caused by a lifestyle that was criminal twenty years ago."Steven Epstein. "Impure Science: AIDS, Activism, and the Politics of Knowledge". University of California Press, Berkeley, CA, 1996. ISBN 0-520-20233-3.] , p. 118

In the following few years, others became skeptical of the HIV theory as researchers initially failed to produce an effective treatment or vaccine for AIDS. [Burkett, E (1996) The Gravest Show on Earth (Chapter 2) ISBN 0-312-14607-8] Journalists such as Neville Hodgkinson and Celia Farber regularly promoted denialist ideas in the American and British media; several television documentaries were also produced to increase awareness of the alternative viewpoint. [ [http://www.virusmyth.net/aids/censorship.htm VirusMyth] , a dissident website, accessed June 2, 2006.] In 1992–1993, "The Sunday Times", where Hodgkinson served as scientific editor, ran a series of articles arguing that the AIDS epidemic in Africa was a myth. These articles stressed Duesberg's claims and argued that antiviral therapy was ineffective, HIV testing unreliable, and that AIDS was not a threat to heterosexuals. The "Sunday Times" coverage was heavily criticized as slanted, misleading, and potentially dangerous; the scientific journal "Nature" took the unusual step of printing a 1993 editorial calling the paper's coverage of HIV/AIDS "seriously mistaken, and probably disastrous." [ [http://query.nytimes.com/gst/fullpage.html?res=9F0CE5DD173EF933A25751C1A965958260 British Paper and Science Journal Clash on AIDS] , by William E. Schmidt. Published in the "New York Times" on December 10, 1993; accessed April 25, 2008.]

Finding difficulty in publishing his arguments in the scientific literature, Duesberg exercised his right as a member of the National Academy of Sciences to publish in "Proceedings of the National Academy of Sciences" (PNAS) without going through the peer review process. However, Duesberg's paper raised a "red flag" at the journal and was submitted by the editor for non-binding review. All of the reviewers found major flaws in Duesberg's paper; the reviewer specifically chosen by Duesberg noted the presence of "misleading arguments", "nonlogical statements", "misrepresentations", and political overtones.cite journal |author=Booth W |title=AIDS paper raises red flag at PNAS |journal=Science |volume=243 |issue=4892 |pages=733 |year=1989 |pmid=2916121|doi=10.1126/science.2916121] Ultimately, Duesberg's article was published in PNAS;cite journal |author=Duesberg PH |title=Human immunodeficiency virus and acquired immunodeficiency syndrome: correlation but not causation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue=3 |pages=755–64 |year=1989 |pmid=2644642|doi=10.1073/pnas.86.3.755] its editor wrote to Duesberg:

In the lay press and via the Internet

With the introduction of highly active antiretroviral therapy (HAART) in 1996–1997, the survival and general health of people with HIV improved significantly. The positive response to treatment with anti-HIV medication cemented the scientific acceptance of the HIV/AIDS paradigm, and led several prominent AIDS denialists to accept the causative role of HIV. Finding their arguments increasingly discredited by the scientific community, denialists took their message to the popular press. A former denialist wrote:In addition to elements of the popular and alternative press, AIDS denialist ideas are propagated largely via the Internet. A 2007 article in "PLoS Medicine" noted:Quotation|Because these denialist assertions are made in books and on the Internet rather than in the scientific literature, many scientists are either unaware of the existence of organized denial groups, or believe they can safely ignore them as the discredited fringe. And indeed, most of the HIV deniers' arguments were answered long ago by scientists. However, many members of the general public do not have the scientific background to critique the assertions put forth by these groups, and not only accept them but continue to propagate them. cite journal
author=Smith TC, Novella SP
title=HIV denial in the Internet era
journal=PLoS Med.
volume=4
issue=8
pages=e256
year=2007
month=August
pmid=17713982
doi=10.1371/journal.pmed.0040256
url=http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040256&ct=1&SESSID=3d4baa1a64e57d8ff33e9d41eb2335a1
accessdate=2008-05-06
]

AIDS activists have expressed concern that denialist arguments about HIV's harmlessness may be responsible for an upsurge in HIV infections. Denialist claims continue to exert a significant influence in some communities; a survey conducted at minority gay pride events in four American cities in 2005 found that 33% of attendees doubted that HIV caused AIDS. [Hutchinson A.B., Begley E.B. et al. (2005) [http://www.aegis.org/conferences/nhivpc/2005/TP-011.html Mistrust and Conspiracy Beliefs about HIV/AIDS among Participants in Minority Gay Pride Events] . "2005 National HIV Prevention Conference" Abstract TP-011] According to Stephen Thomas, director of the University of Pittsburgh Center for Minority Health:"The HIV Disbelievers", by David France. Published in "Newsweek" on August 19, 2000.]

Impact in South Africa

AIDS denialist claims have had a major political, social, and public health impact in South Africa. The government of President Thabo Mbeki has been sympathetic to the views of AIDS denialists; critics charge that denialist influence has been responsible for a slow and ineffective governmental response to the country's massive AIDS epidemic.

Durban Declaration

In 2000, when the International AIDS Conference was held in Durban, Mbeki convened a Presidential Advisory Panel containing a number of AIDS denialists, including Peter Duesberg and David Rasnick. [http://www.journaids.org/politicsofhiv.php "The Politics of HIV/AIDS in South Africa"] : a Journ-AIDS Fact Sheet. Accessed 26 Feb 2007.] The Advisory Panel meetings were closed to the general press; an invited reporter from the "Village Voice" wrote that Rasnick advocated that HIV testing be legally banned and denied that he had seen "any evidence" of an AIDS catastrophe in South Africa, while Duesberg "gave a presentation so removed from African medical reality that it left several local doctors shaking their heads."

In his address to the International AIDS Conference, Mbeki reiterated his view that HIV was not wholly responsible for AIDS, leading hundreds of delegates to walk out on his speech. [http://news.bbc.co.uk/1/hi/world/africa/826742.stm "Controversy dogs AIDS forum] , from the BBC. Accessed 26 Feb 2007.] Mbeki also sent a letter to a number of world leaders likening the mainstream AIDS research community to supporters of the apartheid regime. The tone and content of Mbeki's letter led diplomats in the U.S. to initially question whether it was a hoax. [ [http://www.villagevoice.com/news/0027,schoofs,16189,1.html Proof Positive: How African Science Has Demonstrated That HIV Causes AIDS] , by Mark Schoof. Published in the "Village Voice", July 5–11 2000 issue. Accessed April 20, 2007.] [ [http://pqasb.pqarchiver.com/washingtonpost/access/52730299.html?dids=52730299:52730299&FMT=ABS&FMTS=ABS:FT&date=Apr+19%2C+2000&author=Barton+Gellman&pub=The+Washington+Post&edition=&startpage=A.01&desc=S.+African+President+Escalates+AIDS+Feud "South African President Escalates AIDS Feud"] , by Barton Gellman. Published in the "Washington Post" on April 19, 2000. Accessed 26 Feb 2007.]

AIDS scientists and activists were dismayed at the president's behavior and responded with the Durban declaration, a document affirming that HIV causes AIDS, signed by over 5,000 scientists and physicians.

Criticism of governmental response

South African health minister Manto Tshabalala-Msimang has also attracted heavy criticism, as she has often promoted nutritional remedies such as garlic, lemons, beetroot and olive oil, to people suffering from AIDS, [ [http://www.health-e.org.za/news/article.php?uid=20031487 "Beetroot battle at world AIDS conference"] , by Anso Thom. Published on Health-e on August 21, 2006. Accessed March 9, 2007.] [ [http://www.mg.co.za/articlepage.aspx?area=/breaking_news/breaking_news__national/&articleid=280903 'Dr Beetroot' hits back at media over Aids exhibition] , article in the Mail & Guardian Online. Accessed 20 Sept 2006.] [ [http://www.aegis.com/news/sapa/2005/sa050604.html Manto again angers AIDS activists] , from AEGIS.com. Accessed 20 Sept 2006.] while emphasizing possible toxicities of antiretroviral drugs, which she has referred to as "poison".PDFlink| [http://www.aidstruth.org/nattrass.pdf AIDS, Science and Governance] |377 KiB ] The South African Medical Association has accused Tshabalala-Msimang of "confusing a vulnerable public". [ [http://www.samedical.org/article.asp?ArticleID=1844 Press Release: SAMA calls for end to misrepresentation on treatment of AIDS] , issued August 29, 2006. From the South African Medical Association website, accessed March 12, 2007.] In September 2006, a group of over 80 scientists and academics called for "the immediate removal of Dr. Tshabalala-Msimang as minister of health and for an end to the disastrous, pseudoscientific policies that have characterized the South African government's response to HIV/AIDS." [http://www.washingtonpost.com/wp-dyn/content/article/2006/09/06/AR2006090600586.html "Scientists Rip S. African AIDS Policies"] , by Terry Leonard. Published in the "Washington Post" on September 6, 2006. Accessed 5 March 2007.] In December 2006, deputy health minister Nozizwe Madlala-Routledge described "denial at the very highest levels" over AIDS. [ [http://www.telegraph.co.uk/health/main.jhtml?view=DETAILS&grid=&xml=/health/2006/12/11/wsa10.xml "African Minister Ends Decade of Denial over AIDS"] , from "The Daily Telegraph". Published online November 12, 2006. Accessed 5 March 2007.] She was subsequently fired by Mbeki. [ [http://news.bbc.co.uk/1/hi/world/africa/6940323.stm Sacked S Africa Minister Hits Out] , from the BBC. Published August 10, 2007; accessed August 11, 2007.]

Mbeki's government has been widely criticized for delaying the rollout of programs to provide antiretroviral drugs to people with advanced HIV disease and to HIV-positive pregnant women. The national treatment program began only after the Treatment Action Campaign (TAC) brought a legal case against Government ministers, claiming they were responsible for the deaths of 600 HIV-positive people a day who could not access medication. [ [http://www.tac.org.za/Documents/MTCTCourtCase/MTCTCourtCase.htm Current Developments Preventing Mother-To-Child HIV Transmission In South Africa: Background, Strategies And Outcomes Of The Treatment Action Campaign Case Against The Minister Of Health] ] South Africa was one of the last countries in the region to begin such a treatment program, and roll-out has been much slower than planned.

At the XVI International AIDS Conference, Stephen Lewis, U.N. special envoy for AIDS in Africa, attacked Mbeki's government for its slow response to the AIDS epidemic and reliance on denialist claims:

In 2002, Mbeki requested that AIDS denialists no longer use his name in denialist literature, and requested that denialists stop signing documents with "Member of President Mbeki's AIDS Advisory Panel".

In early 2005, former South African president Nelson Mandela announced that his son had died of complications of AIDS. Mandela's public announcement was seen as both an effort to combat the stigma associated with AIDS, and as a "political statement designed to… force the President [Mbeki] out of his denial." [ [http://www.time.com/time/magazine/article/0,9171,1015842,00.html "No Place for Denial"] , by Simon Robinson. Published in "Time" magazine on January 9, 2005. Accessed 26 Feb 2007.] [ [http://www.guardian.co.uk/southafrica/story/0,13262,1384732,00.html?gusrc=rss "Mandela's Eldest Son Dies of AIDS"] , by Tom Happold. Published in "The Guardian" on January 6, 2005. Accessed March 9, 2007.]

Potential harm from AIDS denialism

Many AIDS experts and activists have alleged that the AIDS denialist movement endangers lives by persuading people to abandon safer sex or forego HIV testing and treatment. [http://www.kaisernetwork.org/health_cast/uploaded_files/081306_ias_sat_journalism.pdf HIV Science and Responsible Journalism] , presented at the XVI International AIDS Conference, accessed 7 Sept 2006.] [http://www.aids2008.org/admin/images/upload/611.pdf International Experts Meet In Mexico City To Plan AIDS 2008 Programme, With Focus On Latest Developments In HIV Research, Prevention And Care] , International AIDS Society, 20 March 2007, accessed 22 March 2007] In particular, the Durban declaration stated that:

In response to such accusations, the denialist Perth Group has denied encouraging unsafe sex or drug use; indeed, they contend that passive anal sex and drug use increase risk of AIDS and should be avoided. [http://www.theperthgroup.com/LATEST/ResponsetoJohnMoore.doc Perth Group Response to Professor Moore] ] Duesberg argues that although HIV itself is harmless, HIV-infected people are treated with medications which he claims cause AIDS symptoms; therefore, he argues, condom use will "protect people who have an average of 1,000 sexual contacts with HIV-positives from infection, and thus from AIDS caused by anti-HIV medication." [ [http://www.duesberg.com/faq.html Duesberg.com Frequently Asked Questions] ]

ee also

* Actup SF
* HIV and AIDS misconceptions

Other reading

See also Pieter Fourie, "The Political Management of HIV and AIDS in South Africa: One burden too many?" Palgrave Macmillan, 2006, ISBN 0230006671

References

External links

cientific consensus

* [http://www3.niaid.nih.gov/news/focuson/hiv/resources/ National Institute of Allergy and Infectious Diseases (NIAID) Focus on the HIV-AIDS Connection: Resources and Links]
* [http://www.sciencemag.org/feature/data/cohen/cohen.dtl Series of articles in "Science" magazine examining denialist claims]
* [http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040256&ct=1 HIV Denial in the Internet Era] , from PLoS Medicine, August 2007
* [http://www.avert.org/evidence.htm Avert.org: Evidence that HIV causes AIDS]
* [http://www.aegis.com/topics/aids_debate.html AEGIS: News and Views on AIDS Causality]
* [http://www.aidstruth.org AidsTruth.org]

Denialist

* [http://rethinkingaids.com/ Group for the Scientific Reappraisal of the HIV/AIDS Hypothesis]
* [http://www.duesberg.com/ Peter Duesberg website]
* [http://www.theperthgroup.com The Perth Group]


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