Practolol

Practolol
Systematic (IUPAC) name
(RS)-N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 6673-35-4 YesY
ATC code C07AB01
PubChem CID 4883
IUPHAR ligand 555
DrugBank DB01297
ChemSpider 4715 YesY
UNII SUG9176GRW YesY
KEGG D05587 N
ChEBI CHEBI:258351 YesY
ChEMBL CHEMBL6995 YesY
Chemical data
Formula C14H22N2O3 
Mol. mass 266.336 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) is a selective beta blocker that has been used in the emergency treatment of cardiac arrhythmias. Practolol is no longer used as it is highly toxic despite the similarity of its chemical formula to propanolol. The use of practolol has been referred to as the practolol disaster and is considered the worst medical blunders since thalidomide.

Side effects

Side effects are similar to those of other beta blockers, such as bronchoconstriction, cardiac failure, cold extremities, fatigue and depression, hypoglycaemia.[1]

Furthermore, chronic use of practolol may cause oculomucocutaneous syndrome,[1] a severe syndrome whose signs include conjunctivitis sicca and psoriasiform rashes, otitis and sclerosing serositis. This syndrome has not been observed with other such beta blockers.[2]

References

  1. ^ a b Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5. 
  2. ^ rxmed.com > Nadolol Retrieved on July, 2010.

External links

Scientific information / studies
General information



Wikimedia Foundation. 2010.

Look at other dictionaries:

  • practolol — /prakˈtə lol/ noun A drug formerly used to treat cardiac arrhythmia, but suspected of causing side effects including eye damage …   Useful english dictionary

  • practolol — prac·to·lol prak tə .lȯl n a beta blocker C14H22N2O3 used in the control of arrhythmia * * * prac·to·lol (prakґto lol) a beta adrenergic blocking agent having the same actions as propranolol (q.v.). Its use has been found to be associated with… …   Medical dictionary

  • Guanethidine — Systematic (IUPAC) name 2 [2 (azocan 1 yl)ethyl]guanidine Clinical data AHFS/Drugs.com …   Wikipedia

  • Amphetamine — For other uses, see Amphetamine (disambiguation). Amphetamine Systematic (IUPAC) name …   Wikipedia

  • Dimethyltryptamine — Systematic (IUPAC) name 2 (1H indol 3 yl) N …   Wikipedia

  • Epinephrine — Adrenaline and Adrenalin redirect here. For other uses, see Adrenaline (disambiguation). (R) (–) L Epinephrine or (R) (–) L adrenaline …   Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Phenothiazine — Phenothiazine …   Wikipedia

  • Clozapine — Not to be confused with clonazepam or Klonopin. Clozapine Systematic (IUPAC) name …   Wikipedia

  • Pseudoephedrine — Systematic (IUPAC) name ( …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.