Systematic (IUPAC) name
Clinical data
Pregnancy cat.  ?
Legal status  ?
CAS number 6673-35-4 YesY
ATC code C07AB01
PubChem CID 4883
IUPHAR ligand 555
DrugBank DB01297
ChemSpider 4715 YesY
KEGG D05587 N
ChEBI CHEBI:258351 YesY
Chemical data
Formula C14H22N2O3 
Mol. mass 266.336 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) is a selective beta blocker that has been used in the emergency treatment of cardiac arrhythmias. Practolol is no longer used as it is highly toxic despite the similarity of its chemical formula to propanolol. The use of practolol has been referred to as the practolol disaster and is considered the worst medical blunders since thalidomide.

Side effects

Side effects are similar to those of other beta blockers, such as bronchoconstriction, cardiac failure, cold extremities, fatigue and depression, hypoglycaemia.[1]

Furthermore, chronic use of practolol may cause oculomucocutaneous syndrome,[1] a severe syndrome whose signs include conjunctivitis sicca and psoriasiform rashes, otitis and sclerosing serositis. This syndrome has not been observed with other such beta blockers.[2]


  1. ^ a b Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5. 
  2. ^ > Nadolol Retrieved on July, 2010.

External links

Scientific information / studies
General information

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