Krukenberg tumor

A Krukenberg tumor, also Krukenberg tumour, classically refers to a secondary ovarian malignancy whose primary site arose in the gastrointestinal tract. Krukenberg tumors are often found in both ovaries. Microscopically, they are characterized by appearance of mucin-secreting signet-ring cells in the tissue of the ovary; when the primary tumor is discovered, the same signet-ring cells will be found.

Historical

The Krukenberg tumor is named after Friedrich Ernst Krukenberg (1871-1946), [WhoNamedIt|doctor|620] a German doctor who first described them as "fibrosarcoma ovarii mucocellulare carcinomatodes". [F. E. Krukenberg:Über das Fibrosarcoma ovarii mucocellulare (carcinomatodes).Archiv für Gynäkologie, Berlin, 1896, 50: 287-321.]

Etiology and Incidence

Metastatic cancer of the ovary accounts for only about 5% of ovarian cancer; in the remainder, the ovary is the primary cancer site. Krukenberg tumors are the third most common metastatic ovarian cancer (after epithelial and germ-cell tumors) and make up 14% of these cancers. Unlike some forms of cancer, there is no racial bias. Krukenberg tumors are most commonly seen in middle-aged and elderly females, around or following the menopause.

ymptoms

Patients with Krukenberg tumor often come to the attention of their doctor when they present complaining of abdominal or pelvic pain, bloatedness, vaginal bleeding, a change in their menstrual habit or pain during intercourse. These symptoms are non-specific (i.e. they point to a range of problems other than cancer) and a diagnosis can only be made following Computed Tomography (CT) scans, laparotomy and/or a biopsy of the ovary.

Pathogenesis

There is some debate over the exact mechanism of metastasis of the tumour cells from the stomach, appendix or colon to the ovaries; classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but recently some researchers have suggested that lymphatic (i.e. through the lymph nodes), or haematogenous (i.e. through the blood) spread is more likely, as most of these tumours are found on the inside of the ovaries. Proponents of this theory cite the fact that metastases are never found in the omentum (the fatty apron which envelops the organs of the abdomen and lies between the stomach and ovaries), and that the tumor cells are found within the ovary and not growing inwards.However, this remains a controversy, as cases in Hong Kong always showed omental spread and peritoneal seedlings in patients with Krukenberg tumours.

Although a Krukenberg tumor is most commonly a metastasis from a gastric cancer (usually an adenocarcinoma), this is not always the case. Other tumours of the gastrointestinal tract (including, significantly, colon cancer) have been known to cause Krukenberg tumours, and recent case-reports of Krukenberg tumors originating from tumors of the tip of the appendix have appeared in the medical literature.

Treatment and Prognosis

Since the Krukenberg tumor is a secondary (metastatic) tumor, management of the tumor must involve finding and treating the primary cancer. In general, most cases of Krukenberg tumor have a poor prognosis and radical operation such as removal of the ovaries (and the colon or appendix if involved) can improve survival only in cases of solitary ovarian metastasis or local extended disease (i.e. the lesion is located only in the pelvis). Cancer chemotherapy and radiotherapy before surgery may be used to shrink the tumor and facilitate its removal.

References

External links

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Look at other dictionaries:

  • Krükenberg, tumor de — oncol. Carcinoma de origen gástrico que provoca metástasis en el ovario. Es común que primero se diagnostique la metástasis en el ovario y posteriormente se detecte el tumor intestinal primigenio. Medical Dictionary. 2011 …   Diccionario médico

  • Krukenberg-Tumor —   [nach dem Pathologen Friedrich Krukenberg, * 1871, ✝ 1946], sekundäre, durch Metastasen v. a. bei Magen und Darmkrebs hervorgerufene bösartige Gewebeneubildung der Eierstöcke (Ovarialkarzinom) …   Universal-Lexikon

  • Krukenberg-Tumor — Klassifikation nach ICD 10 C79 Sekundäre bösartige Neubildung an sonstigen Lokalisationen …   Deutsch Wikipedia

  • Krukenberg tumor — A tumor of the ovary caused by the spread of stomach cancer. When the stomach cancer spreads to an ovary, the tumor in the ovary is called a Krukenberg tumor. (This tumor, named for a doctor, is not a different disease; it is metastatic stomach… …   Medical dictionary

  • krukenberg tumor — ˈkrükənˌbərg noun Usage: usually capitalized K Etymology: after Friedrich E. Krukenberg b1871 German pathologist : a metastatic ovarian tumor of mucin producing epithelial cells usually derived from a primary gastrointestinal tumor …   Useful english dictionary

  • Krukenberg-Tumor — Kru̱kenberg Tumor [nach dem dt. Pathologen Friedrich Krukenberg, 1871 1946]: doppelseitige Eierstocksgeschwulst …   Das Wörterbuch medizinischer Fachausdrücke

  • Krukenberg tumor — A tumor in the ovary caused by the spread of stomach cancer …   English dictionary of cancer terms

  • tumor de Krukenberg — tumor de Krükenberg Krükenberg, tumor de oncol. Carcinoma de origen gástrico que provoca metástasis en el ovario. Es común que primero se diagnostique la metástasis en el ovario y posteriormente se detecte el tumor intestinal primigenio. Medical… …   Diccionario médico

  • Krukenberg — ist der Name von Carl Friedrich Wilhelm Krukenberg (1852–1889), deutscher Physiologe Friedrich Ernst Krukenberg (1871–1946), deutscher Mediziner Georg Krukenberg (1856–1899), deutscher Gynäkologe Gustav Krukenberg (1888 1980), deutscher… …   Deutsch Wikipedia

  • Tumor de Krukenberg — Contenido 1 Definición 2 Historia 3 Síntomas 4 Tratamiento Definición Un tumor de Krukenberg, también como tumor de Krukenberg, clásicam …   Wikipedia Español


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