Name = glutamic-pyruvate transaminase
HGNCid = 4552
Symbol = GPT
EntrezGene = 2875
OMIM = 138200
RefSeq = NM_005309
UniProt = P24298
ECnumber = 220.127.116.11
Chromosome = 8
Arm = q
Band = 24.2
LocusSupplementaryData = -qter
Alanine transaminase or ALT is a
transaminase enzyme(EC number|18.104.22.168). It is also called serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALAT).
ALT is found in serum and in various bodily tissues, but is most commonly associated with the
It catalyzes the transfer of an
aminogroup from alanineto a-ketoglutarate, the products of this reversible transaminationreaction being pyruvateand glutamate.
glutamate+ pyruvateunicode| α-ketoglutarate + alanine
It is commonly measured clinically as a part of a diagnostic
liver function test, to determine liver health. Diagnostically, it is almost always measured in units/litre (U/L).
Significantly elevated levels of ALT often suggest the existence of other medical problems such as viral
hepatitis, congestive heart failure, liverdamage, biliary ductproblems, infectious mononucleosis, or myopathy. For this reason, ALT is commonly used as a way of screening for liver problems. However, elevated levels of ALT do not automatically mean that medical problems exist. Fluctuation of ALT levels is normal over the course of the day, and ALT levels can also increase in response to strenuous physical exercise [Paul T. Giboney M.D., [http://www.aafp.org/afp/20050315/1105.html Mildly Elevated Liver Transaminase Levels in the Asymptomatic Patient] , "American Family Physician".] .
When elevated ALT levels are found in the blood, the possible underlying causes can be further narrowed down by measuring other enzymes. For example, elevated ALT levels due to liver-cell damage can be distinguished from
biliary ductproblems by measuring alkaline phosphatase. Also, myopathy-related ALT levels can be ruled out by measuring creatine kinaseenzymes. Several drugs elevates the ALT levels. For example, Zileuton, the lipoxygenase inhibitor used in the treatment of acute asthmaexacerbation.
For years, the
American Red Crossused ALT testing as part of the battery of tests to ensure the safety of its blood supply by deferring donors with elevated ALT levels. The intent was to identify donors potentially infected with Hepatitis C("non-A non-B Hepatitis") because there was no specific test for that disease at the time. With the introduction of second generation ELISAantibody tests for Hepatitis C, the Red Cross changed the ALT policy. As of July 2003, donors previously disqualified for elevated ALT levels and no other reason may be reinstated as donors by contacting the donor counseling department of their regional Red Cross organization [ [http://www.tompkins-redcross.org/donor_req.htm Red Cross Donor Requirements] ] .
Liver function tests
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