Polycystic kidney disease

Polycystic kidney disease
Classification and external resources

Polycystic kidneys
ICD-10 Q61
ICD-9 753.1
OMIM 173900
DiseasesDB 10262 10280
MedlinePlus 000502
eMedicine med/1862 ped/1846 radio/68 radio/69
MeSH D007690

Polycystic Kidney Disease (PKD or PCKD, also known as polycystic kidney syndrome) is a cystic genetic disorder of the kidneys.[1] There are two types of PKD: Autosomal Dominant Polycystic Kidney Disease (ADPKD) and the less-common Autosomal Recessive Polycystic Kidney Disease (ARPKD).

It occurs in humans and some other animals. PKD is characterized by the presence of multiple cysts (hence, "polycystic") typically in both kidneys; however 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.[2] The cysts are numerous and are fluid-filled, resulting in massive enlargement of the kidneys. The disease can also damage the liver, pancreas and, in some rare cases, the heart and brain. The two major forms of polycystic kidney disease are distinguished by their patterns of inheritance.

Polycystic Kidney Disease is the most common life-threatening genetic disease, affecting an estimated 12.5 million people worldwide.[citation needed] In half of the people with Polycystic Kidney Disease, there is no family history of the disease. In these cases, the gene coding for the disease occurs out of a spontaneous genetic mutation without either parent being a carrier of the gene.[citation needed]

Contents

Types

Autosomal dominant

ADPKD is the most common of all the hereditary cystic kidney diseases [2][3][4] with an incidence of 1 to 2:1,000 live births.[2][4] Studies show that 10% of end-stage renal disease (ESRD) patients being treated with hemodialysis in Europe and the U.S. were initially diagnosed and treated for ADPKD.[2] ADPKD does not appear to demonstrate a preference for any particular ethnicity.

ADPKD is characterized by progressive cyst development and bilaterally enlarged kidneys with multiple cysts. There are three genetic mutations in the PKD-1, PKD-2, and PKD3 gene with similar phenotypical presentations. Gene PKD-1 is located on chromosome 16 and codes for a protein involved in regulation of cell cycle and intracellular calcium transport in epithelial cells, and is responsible for 85% of the cases of ADPKD. A group of voltage-linked calcium channels are coded for by PKD-2 on chromosome 4. PKD3 recently appeared in research papers as a postulated 3rd gene. At this time, PKD3 has not been proven.[2][3] Fewer than 10% of cases of ADPKD appear in non-ADPKD families.

Cyst formation begins in utero from any point along the nephron, although fewer than 5% of nephrons are thought to be involved. As the cysts accumulate fluid, they enlarge, separate entirely from the nephron, compress the neighboring renal parenchyma, and progressively compromise renal function.

Under the function of gene defect, epithelial cells of renal tubule turn into epithelial cells of cyst wall after phenotype change, and begin to have the function of secreting cyst fluid, which leads to continuous cysts enlargement.[5]

Autosomal Recessive

Studies show that the incidence of ARPKD (OMIM #263200) is 1:20,000 live births and is typically identified in the first few weeks after birth. Unfortunately, resulting hypoplasia results in a 30% death rate in neonates with ARPKD.[2] In ARPKD kidneys retain their shape but are larger than the normal anatomical range with dilated collecting ducts from the medulla to the cortex.

Extrarenal manifestations

The major extrarenal complications of ADPKD include cerebral aneurysms, hepatic cysts, pancreatic cysts, cardiac valve disease, colonic diverticula, and aortic root dilatation.

References

  1. ^ "polycystic kidney disease" at Dorland's Medical Dictionary
  2. ^ a b c d e f Bisceglia, M; et al (2006). "Renal cystic diseases: a review". Advanced Anatomic Pathology (13): 26–56. 
  3. ^ a b Torres, WE; Harris PC, Pirson Y (2007). "Autosomal dominant polycystic urology". Lancet 369 (9569): 1287–301. doi:10.1016/S0140-6736(07)60601-1. 
  4. ^ a b Simons, M; Walz G (2006). "Polycystic kidney disease: cell division with a c(l)ue?". Kidney International (70): 854–864. 
  5. ^ 梅长林,常染色体显性多囊肾病,肾脏病学,第三版,人民卫生出版社|year=2008,9|pages=1746

External links


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Look at other dictionaries:

  • Polycystic kidney disease 2 — (autosomal dominant), also known as PKD2, is a human gene.cite web | title = Entrez Gene: PKD2 polycystic kidney disease 2 (autosomal dominant)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5311|… …   Wikipedia

  • Polycystic Kidney Disease — (PKD) ist eine vererbte Erkrankung der Niere beim Menschen, siehe Zystenniere bei Perserkatzen, siehe PKD der Katze Diese Seite ist eine Begriffsklärung …   Deutsch Wikipedia

  • Polycystic kidney disease — Genetic disorder characterized by the development of innumerable cysts in the kidneys. These cysts are filled with fluid, and replace much of the mass of the kidneys. This reduces kidney function, leading to kidney * * * polycystic kidney disease …   Medical dictionary

  • Polycystic kidney disease 1 — Schematische Darstellung von Polycystin 1 und Polycystin 2 an einer Zelle.[1] PKD1 (engl. Abk. für polycystic kidney disease 1 (autosomal dominant) = „polyzystische Nierenerkrankung 1 (autosomal dominant)“) ist ein Gen, das sowohl beim Menschen… …   Deutsch Wikipedia

  • polycystic kidney disease — noun kidney disease characterized by enlarged kidneys containing many cysts; often leads to kidney failure • Syn: ↑PKD • Hypernyms: ↑kidney disease, ↑renal disorder, ↑nephropathy, ↑nephrosis * * * noun : either of two he …   Useful english dictionary

  • polycystic kidney disease — noun Date: 1948 either of two hereditary diseases characterized by gradually enlarging bilateral cysts of the kidney which lead to reduced renal functioning or renal failure …   New Collegiate Dictionary

  • autosomal dominant polycystic kidney disease — (ADPKD) see polycystic kidney d …   Medical dictionary

  • autosomal recessive polycystic kidney disease — (ARPKD) see polycystic kidney d …   Medical dictionary

  • Polycystic liver disease — Classification and external resources Micrograph showing a von Meyenburg complex, a bile duct hamartoma associated with polycystic liver disease. Trichrome stain …   Wikipedia

  • polycystic liver disease — any of several congenital conditions in which the liver develops cysts and sometimes Meyenburg complexes, often in association with polycystic kidney disease. An autosomal recessive type develops in childhood and can be rapidly fatal; an… …   Medical dictionary


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