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IUPACName = 4-Methylthio-2,5-dimethoxyphenethylamine
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Section1 = Chembox Identifiers
CASNo = 61638-09-3
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SMILES = COc1cc(SC)c(OC)cc1CCN

Section2 = Chembox Properties
Formula = C11H17NO2S
MolarMass = 227.32 g/mol
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Section3 = Chembox Hazards
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2C-T (or 4-methylthio-2,5-DMPEA) is a psychedelic and hallucinogenic drug of the 2C family. It is used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs mescaline and 2C-T-2. It was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin.cite journal |author=Nichols DE, Shulgin AT |title=Sulfur analogs of psychotomimetic amines |journal=J Pharm Sci |volume=65 |issue=10 |pages=1554–6 |year=1976 |month=October |pmid=978423 |doi= |url=]


2C-T is in a class of compounds commonly known as phenethylamines, and is the 4-methylthio analogue of 2C-O, a positional isomer of mescaline. It is also the 2C analog of Aleph. The full name of the chemical is 4-methylthio-2,5-dimethoxyphenethylamine. The CAS number of 2C-T is 61638-09-3.


2C-T's active dosage is around 75-150mg and produces mescaline and MDMA-like effects that may last up to 6 hours. [CitePiHKAL]


The mechanism that produces 2C-T’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.


The toxicity of 2C-T is not well documented. 2C-T is considerably less potent than other related drugs such as 2C-T-7, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as 2C-T-7 and 4-MTA are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome when they are combined with stimulant drugs. Most confirmed fatalities involving 2C-T drugs involve their combination with other hard drugs such as alcohol, ecstasy or cocaine.


2C-T is almost unknown on the black market although it has rarely been sold by "research chemical" companies. Limited accounts of 2C-T can be found in the book "PiHKAL (Phenethylamines i Have Known And Loved)".


2C-T is unscheduled and unregulated in the United States; however its close similarity in structure and effects to 2C-T-7 could potentially subject possession and sale of 2C-T to prosecution under the Federal Analog Act. This seems to be the tack the federal government is taking in the wake of the DEA's Operation Web Tryp. A series of court cases in the US involving the prosecution of several online vendors were commenced in 2004 and resulted in a number of convictions.cite web |url=http://www.erowid.org/psychoactives/research_chems/research_chems_info1.shtml |title=Erowid Psychoactive Vaults : Research Chemicals : DEA Announces Arrests and Investigation, July 22 2004 |format= |work= |accessdate=]


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External links

* [http://www.erowid.org/library/books_online/pihkal/pihkal039.shtml 2C-T Entry in PiHKAL]

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