Name = Binswangers disease
DiseasesDB = 1405
ICD10 = ICD10|I|67|3|i|60
ICD9 = ICD9|290.12
MeshID = D015140
Binswanger's disease or Subcortical Leukoencephalopathy is a rare form of
multi-infarct dementiacaused by damage to white brain matter.cite journal |author=Akiguchi I, Tomimoto H, Suenaga T, Wakita H, Budka H |title=Alterations in glia and axons in the brains of Binswanger's disease patients |journal=Stroke |volume=28 |issue=7 |pages=1423–9 |year=1997 |pmid=9227695 |doi= |url=http://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=9227695] It is characterized by loss of memory and intellectual function and by changes in mood.
It was described by
Otto Binswangerin 1894.cite journal |author=Pantoni L, Moretti M, Inzitari D |title=The first Italian report on "Binswanger's disease" |journal=Ital J Neurol Sci |volume=17 |issue=5 |pages=367–70 |year=1996 |pmid=8933231|doi=10.1007/BF01999900] Alois Alzheimerfirst used the phrase "Binswanger's disease" in 1902.cite web |url=http://findarticles.com/p/articles/mi_m2459/is_n1_v23/ai_14904670 |title=Review: Binswanger's disease, leukoaraiosis and dementia | Age and Ageing | Find Articles at BNET.com |accessdate=2008-01-30 |format= |work=]
It was more formally described by Olszewski in 1962.cite journal |author=Loeb C |title=Binswanger's disease is not a single entity |journal=
Neurol. Sci.|volume=21 |issue=6 |pages=343–8 |year=2000 |pmid=11441570 |doi= 10.1007/s100720070048|url=http://link.springer-ny.com/link/service/journals/10072/bibs/0021006/00210343.htm] cite journal |author=Olszewski J |title=Subcortical arteriosclerotic encephalopathy. Review of the literature on the so-called Binswanger's disease and presentation of two cases |journal=World Neurol |volume=3 |issue= |pages=359–75 |year=1962 |pmid=14481961 |doi=]
The term is sometimes considered too imprecise for formal
nosology.cite journal |author=Pantoni L, Garcia JH |title=The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review |journal=Stroke |volume=26 |issue=7 |pages=1293–301 |year=1995 |pmid=7604429 |doi= |url=http://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=7604429]
Binswanger's disease is one of the
neurologicalsyndromes associated with hypertension. It is uncommon, but obviously devastating. The histologic findings are diffuse, irregular loss of axonsand myelinaccompanied by widespread gliosis. Small infarcts may be seen in the frontal lobes. The pathologic mechanism may be damage caused by severe atherosclerosis.
A patient with long term severe hypertension develops progressive
dementia. CT scans of the head demonstrate a diffuse loss of deep hemispheric white matter.
Binswanger's disease has no known treatment, let alone cure, although drugs used to treat
high blood pressure, depression, arrhythmiaand low blood pressureare used to treat the condition's symptoms. [NINDS|binswangers]
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