Proteinase 3

Proteinase 3

PDB rendering based on 1fuj.
Symbols PRTN3; ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP4; P29; PR-3; PR3
External IDs OMIM177020 MGI893580 HomoloGene20615 GeneCards: PRTN3 Gene
EC number
RNA expression pattern
PBB GE PRTN3 207341 at tn.png
More reference expression data
Species Human Mouse
Entrez 5657 19152
Ensembl ENSG00000196415 ENSMUSG00000057729
UniProt P24158 Q61096
RefSeq (mRNA) NM_002777.3 NM_011178.2
RefSeq (protein) NP_002768.3 NP_035308.2
Location (UCSC) Chr 19:
0.84 – 0.85 Mb
Chr 10:
79.34 – 79.35 Mb
PubMed search [1] [2]

Proteinase 3 also known as PRTN3 is an enzyme which in humans is encoded by the PRTN3 gene.[1]



PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.[2]


  1. ^ Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". J. Exp. Med. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701. 
  2. ^ van der Geld YM, Limburg PC, Kallenberg CG (February 2001). "Proteinase 3, Wegener's autoantigen: from gene to antigen". J. Leukoc. Biol. 69 (2): 177–90. PMID 11272267. 

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