List of recombinant proteins
Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature
Human recombinants that largely replaced animal or harvested from human types
*Human growth hormone (rhGH) Humatrope from Lilly and Serostim from
Serono replacedcadaver harvested human growth hormone
*Human insulin (rhI) Humulin from Lilly and Novolin fromNovo Nordisk among others; largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal-sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce hypoglycemia unawareness. Remaining manufacturers of highly-purified animal-sourced insulin include the U.K.'s Wockhardt Ltd. (headquartered in India), Poland's Polfa Tarchomin S.A., Argentina's Laboratorios Beta S.A., and China's Wanbang Biopharma Co.
*Follicle-stimulating hormone FSH replacedSerono 'sPergonal which was previously isolated from post-menopausal female urine
*Factor VIII Kogenate fromBayer replacedblood harvested factor VIIIHuman recombinants with recombination as only source
*
Erythropoietin (EPO) Epogen fromAmgen
*Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen fromAmgen ; pegfilgrastim sold as Neulasta
*alpha-glactosidase A Fabrazyme byGenzyme
*alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme byBioMarin Pharmaceutical andGenzyme
*N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) byBioMarin Pharmaceutical
*DNAse Pulmozyme byGenentech
*Tissue plasminogen activator (TPA) Activase byGenentech
*Glucocerebrosidase Ceredase byGenzyme
*Interferon (IF) Interferon-beta-1a as Avonex from Biogen Idec; Rebif fromSerono ; Interferon beta-1b as Betaseron fromSchering
*Insulin-like growth factor 1 (IGF-1)Animal recombinants
*
Bovine somatotropin (bST)
*Porcine somatotropin (pST)
*Bovine Chymosin Viral recombinants
*Envelope protein of the
hepatitis B virus marketed as Engerix-B bySmithKline Beecham
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