Low-dose chemotherapy

Low-dose Chemotherapy is being studied/used in the treatment of cancer to avoid the devastating side effects of conventional chemotherapy. Historically, oncologists have used the highest possible dose that the body can tolerate in order to kill as many cancer cells as possible. cite web | author= | title=Jefferson Study Shows Low Concentrations of Chemotherapy Drugs Reduce Tumor Size and Have Antiangiogenic Effects | url=http://www.kimmelcancercenter.org/kcc/clinical/kccnews/LowDose.htm | date=April 18, 2003 | publisher=Kimmel Cancer Center, Jefferson Cancer Network | accessdate=2006-10-22 - study on mice in which human choriocarcinoma had been implanted] After high-dose treatments the body reacts, sometimes quite severely. Unfortunately normal cells, vital organs and the immune system often cannot tolerate the chemo's poisonous assaultOr|date=September 2007. Infections from external causes become a leading threat of death.

Some have suggested that the chemotherapy "cure is worse than the cancer"Fact|date=February 2007 because of the hair loss and constant vomiting that are so common in chemo patients. Some in the patient community state that death by chemotherapy is actually common. They claim the incidence of death by chemotherapy is invisible to most researchers because of the way that deaths are reported to the authorities.Fact|date=February 2007

Some major pharmaceutical companies have spent hundreds of millions of dollars to get FDA approval for drugs to restore cancer patients' immune system. [cite news | author=Cancer Therapy Evaluation Program | title=Amgen Receives European Commission Approval For Both Aranesp and Neulasta in Oncology -- These Unique, Long-Acting Molecules Represent Major Advances in Improving The Management of Anaemia and of Chemotherapy-Induced Infections | url=http://ctep.cancer.gov/resources/gcig/news1.html | publisher=National Cancer Institute | accessdate=2006-10-22]

Forms of low-dose chemotherapy

The following forms of low-dose chemotherapy have been proposed. They are not always widely available treatments at hospitals.

Oral low-dose chemotherapy

Patients are given chemotherapy drugs orally very frequently. This approach can be very effective for some cancer and can minimize side effects for some people. More patients are using oral chemo than ever before. [cite news | author= | title=Oral Chemotherapy Will Play a Larger Role in Cancer Treatment | url=http://www.medicalnewstoday.com/medicalnews.php?newsid=29230 | date=17 Aug 2005 | publisher=Medical News Today | accessdate=2006-10-22] [cite journal | author=Smith I , Johnston S, O'Brien M , Hickish T, de Boer R, Norton A, Cirkel D, Barton C | title=Low-Dose Oral Fluorouracil With Eniluracil as First-Line Chemotherapy Against Advanced Breast Cancer: A Phase II Study | journal=Journal of Clinical Oncology | volume=18 | issue=12 | pages=2378–84 | year=2000 | month=Jun | url=http://www.jco.org/cgi/content/full/18/12/2378 | pmid=10856097]

Low-dose chemotherapy and antiangiogenesis

Adam Dicker, M.D., Ph.D., associate professor, Jefferson Medical College of Thomas Jefferson University in Philadelphia, supports that chemotherapy is often used in the highest possible doses. They are rethinking chemotherapy because of the antiangiogenic effects of lowdose chemotherapy given on a more frequent basis than conventional chemo. They have shown excellent antiangiogenic results in the laboratory.

Insulin potentiation therapy low-dose chemotherapy

Although yet to be proven, Insulin potentiation therapy (IPT) proponents suggest that insulin modifies cancer cells receptivity to being penetrated by the chemotherapy. Cancer cells secrete their own insulin and insulin-like growth factor (IGF) which work together to consume your body's nutrients to grow cancer. Cancer cell membranes have about sixteen times more insulin and IGF receptors than normal cells and these receptors react with synthetic insulin. When insulin is administered, the cancer starves for glucose and generates enzyme activity that makes the cell membrane more permeable. The chemotherapy drug gets absorbed by the cancer. By using the very same mechanisms that cancer cells use to grow and kill people, IPT channels the chemotherapy drug directly inside the cancer cells leaving normal cells alone. [ [http://www.elkabest.org The Elka Best Foundation] ] [cite web | author=Cancer Advisory Panel for Complementary and Alternative Medicine (CAPCAM) | title=Minutes of the Third Meeting | url=http://nccam.nih.gov/about/advisory/capcam/minutes/2000sept.htm | date=September 18, 2000 | publisher=National Centre for Complementary and Alternative Medicine | accessdate=2006-10-22]

Insulin therapy is not the same as IPT Low-dose Chemotherapy. Insulin on its own modulates the transportation of nutrients and more throughout the body. There have been several attempts to use insulin in a variety functions that have proven ill advised.


There are many other researchers looking for low-dose chemotherapy treatments. [cite web | title=Low Dose Chemotherapy | url=http://www.cancerprotocol.com/low_dose_chemotherapy.html | publisher=CancerProtocol.com | accessdate=2006-10-22] [cite journal | author = Lu W, Li Y, He X, Chen Y | title = Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: evaluation of two kinds of dosages of anticancer drugs and analysis of prognostic factors | journal = Hepatogastroenterology | volume = 50 | issue = 54 | pages = 2079–83 | year = | pmid = 14696468] [cite journal | author=Strum S | title=Important Principles in Chemotherapy: Regimens Treating And Androgen-Independent Prostate Cancer (AIPC) | journal=PCRI Insights | year=1999 | month=Dec | volume=2 | issue=4 | url=http://www.prostate-cancer.org/education/sidefx/Strum_PrinciplesInChemotherapy.html | format=Reprint | accessdate=2006-10-22]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Chemotherapy — A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on her hands and feet to reduce harm to her nails. Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an… …   Wikipedia

  • Chemotherapy-induced neutropenia — is a condition characterized by abnormally low blood levels of infection fighting neutrophils, a specific kind of white blood cell.cite journal |author=Lyman GH |title=Risks and consequences of chemotherapy induced neutropenia |journal=Clin… …   Wikipedia

  • History of cancer chemotherapy — The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. Cancer drug development has exploded since then into a multi billion dollar industry. The targeted therapy revolution has… …   Wikipedia

  • Breast cancer chemotherapy — refers to the use of cytotoxic drugs (chemotherapy) in the treatment of breast cancer. Types Chemotherapy can be given both before and after surgery. Neoadjuvant chemotherapy is used to shrink the size of a tumor prior to surgery. Adjuvant… …   Wikipedia

  • Insulin potentiation therapy — (IPT) is an alternative cancer treatment using insulin and low dose chemotherapy.[1] The therapeutic approach is said to take advantage of the endogenous molecular biology of cancer cells, specifically the secretion of insulin and insulin like… …   Wikipedia

  • Experimental cancer treatment — Experimental cancer treatments are medical therapies intended or claimed to treat cancer (see also tumor ) by improving on, supplementing or replacing conventional methods (surgery, chemotherapy, radiation, and immunotherapy).The entries listed… …   Wikipedia

  • Desmoplastic small-round-cell tumor — Classification and external resources Micrograph of a desmoplastic small round cell tumor, showing the characteristic desmoplastic stroma and angulated nests of small round cells. H …   Wikipedia

  • Desmoplastic small round cell tumor — DiseaseDisorder infobox Name = Desmoplastic small round cell tumor ICD10 = ICD9 = ICDO = 8806/3 Desmoplastic small round cell tumor is classified as a soft tissue sarcoma. It is an aggressive and rare tumor that primarily occurs as multiple… …   Wikipedia

  • Desmoid tumor — Desmoid tumors are benign soft tissue tumors that occur most often in young adults and involve the limbs or trunk but can also arise in the abdomen or thorax. Desmoid tumors are benign. They never metastasize (spread to other parts of the body).… …   Medical dictionary

  • Tumor, desmoid — Desmoid tumors are benign soft tissue tumors that occur most often in young adults and involve the limbs or trunk but can also arise in the abdomen or thorax. Desmoid tumors are benign. They never metastasize (spread to other parts of the body).… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.