Berylliosis Classification and external resources
ICD-10 J63.2 ICD-9 503 eMedicine med/222
Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by exposure to beryllium and its compounds. As an occupational lung disease, it is most classically associated with beryllium mining or manufacturing of fluorescent light bulbs (which used to contain beryllium compounds in their internal phosphor coating). 
The condition is incurable, but symptoms can be treated.
With single or prolonged exposure by inhalation, the lungs become hypersensitive to beryllium causing the development of small inflammatory nodules, called granulomas.
Ultimately, this process leads to restrictive lung disease, a decreased diffusion capacity.
Rarely, one can get granulomas in other organs including the liver.
The onset of symptoms can range from weeks up to tens of years from the initial exposure. In some individuals a single exposure can cause berylliosis.
History as occupational disease
Cases of bronchitis and pneumonia-like symptoms were reported in Germany and Russia in the 1930's, among workers mining and refining beryllium. By 1946, a cluster of cases associated with fluorescent lamp manufacturers were apparent in the United States, and the lamp industry stopped using beryllium in 1949. The level of reaction of individuals varies greatly, with some not developing symptoms until years after exposure within industrial plants, but other workers only exposed to traces of dust became affected as well. A study found 1% of people living within 3/4 of a mile of a beryllium plant in Lorain, Ohio, had berylliosis after exposure to concentrations estimated to be less than 1 milligram per cubic metre of air. In the United States the Beryllium Case Registry contained 900 records, early cases relating to extraction and fluorescent lamp manufacture, later ones coming from the ceramics and metallurgical industries. 
- ^ U.S. Army Center for Health Promotion and Preventive Medicine. "USACHPPM: Just the Facts: Beryllium Exposure & Berylliosis". http://chppm-www.apgea.army.mil/documents/FACT/64-003-0302.pdf. Retrieved 2010-01-24.
- ^ General Electric Fluorescent Lamps TP 111R, Dec. 1978, says on pg. 23 that since 1949 GE lamps used relatively inert phosphates found to be safe in ordinary handling of either the intact or broken lamp.
- ^ Dweik, Raed A (2008-11-19). "Berylliosis: Treatment & Medication". Medscape. http://emedicine.medscape.com/article/296759-treatment. Retrieved 2009-08-21.
- ^ David Geraint James, Alimuddin Zumla, The granulomatous disorders, Cambridge University Press, 1999, ISBN 0521592216, pages 336-337
- ATSDR Case Studies in Environmental Medicine: Beryllium Toxicity U.S. Department of Health and Human Services
- Beryllium Network
- Instant insight from the Royal Society of Chemistry examining the molecular basis of chronic beryllium disease
- Chapter Seven Salem Sarcoid:The Origins of Beryllium Disease", in David Rosner, Gerald E. Markowitz (ed) Dying for work: workers' safety and health in twentieth-century America, Indiana University Press, 1987 ISBN 0253318254
Pathology of respiratory system (J, 460–519), respiratory diseases Upper RT
Common cold)Headvocal folds: Laryngopharyngeal reflux (LPR) · Vocal fold nodule · Vocal cord paresis · Vocal cord dysfunction
Lower RT/lung disease
(including LRTIs)acute: Acute bronchitischronic: COPD (Chronic bronchitis, Acute exacerbations of chronic bronchitis, Acute exacerbation of COPD, Emphysema) · Asthma (Status asthmaticus, Aspirin-induced, Exercise-induced) · BronchiectasisInterstitial/
restrictiveBy pathogenBy vector/routeBy distributionBroncho- · LobarOther
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Look at other dictionaries:
berylliosis — [bə ril΄ē ō′sis] n. pl. beryllioses [bə ril΄ē ō′sēz΄] a serious disease caused by beryllium poisoning, usually found in the lungs from the inhalation of beryllium fumes or particles … English World dictionary
berylliosis — Beryllium poisoning characterized by the occurrence of acute pneumonia or chronic interstitial granulomatous fibrosis, especially of the lungs, from inhalation of beryllium. * * * be·ryl·li·o·sis bə .ril ē ō səs also ber·yl … Medical dictionary
berylliosis — /beuh ril ee oh sis/, n. Pathol. beryllium poisoning, characterized by the formation of granulomas, primarily affecting the lungs and causing a cough, chest pain, and shortness of breath. [BERYLLI(UM) + OSIS] * * * ▪ disease systemic… … Universalium
berylliosis — n. poisoning by beryllium or its compounds, either by inhalation or by skin contamination. Inhalation of fumes from molten beryllium causes an acute alveolitis and is usually fatal. Subacute and chronic forms can result from extremely low levels… … The new mediacal dictionary
berylliosis — noun a chronic disease of the lungs caused by inhalation of beryllium compounds … Wiktionary
berylliosis — be·ryl·li·o·sis … English syllables
berylliosis — … Useful english dictionary
chronic berylliosis — the usual form of berylliosis, characterized by beryllium granulomas (q.v.), a diffuse inflammatory reaction that may be indistinguishable from sarcoidosis, and sometimes dyspnea and hypertrophic pulmonary osteoarthropathy. In time the granulomas … Medical dictionary
Бериллиоз (Berylliosis) — отравление бериллием или его соединениями, развивающееся либо при вдыхании паров бериллия, либо при его попадании на кожу. Вдыхание паров жидкого бериллия вызывает у человека острый альвеолит и обычно заканчивается смертью больного. Подострая и… … Медицинские термины
acute berylliosis — an often fulminating reaction to inhalation of beryllium, characterized by a toxic or allergic pneumonitis, sometimes with rhinitis, pharyngitis, and tracheobronchitis. Symptoms may last for weeks, and serious cases can be fatal … Medical dictionary