Interleukin 9

Interleukin 9, also known as IL9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.cite web | title = Entrez Gene: IL9 interleukin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3578| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.cite web | title = Entrez Gene: IL9 interleukin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3578| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Renauld JC, Houssiau F, Louahed J, "et al." |title=Interleukin-9. |journal=Adv. Immunol. |volume=54 |issue= |pages= 79–97 |year= 1993 |pmid= 8379467 |doi=
*cite journal | author=Knoops L, Renauld JC |title=IL-9 and its receptor: from signal transduction to tumorigenesis. |journal=Growth Factors |volume=22 |issue= 4 |pages= 207–15 |year= 2005 |pmid= 15621723 |doi= 10.1080/08977190410001720879
*cite journal | author=Modi WS, Pollock DD, Mock BA, "et al." |title=Regional localization of the human glutaminase (GLS) and interleukin-9 (IL9) genes by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=57 |issue= 2-3 |pages= 114–6 |year= 1991 |pmid= 1680606 |doi=
*cite journal | author=Kelleher K, Bean K, Clark SC, "et al." |title=Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. |journal=Blood |volume=77 |issue= 7 |pages= 1436–41 |year= 1991 |pmid= 1901233 |doi=
*cite journal | author=Holbrook ST, Ohls RK, Schibler KR, "et al." |title=Effect of interleukin-9 on clonogenic maturation and cell-cycle status of fetal and adult hematopoietic progenitors. |journal=Blood |volume=77 |issue= 10 |pages= 2129–34 |year= 1991 |pmid= 1903074 |doi=
*cite journal | author=Merz H, Houssiau FA, Orscheschek K, "et al." |title=Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and large cell anaplastic lymphoma. |journal=Blood |volume=78 |issue= 5 |pages= 1311–7 |year= 1991 |pmid= 1908723 |doi=
*cite journal | author=Renauld JC, Goethals A, Houssiau F, "et al." |title=Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. |journal=J. Immunol. |volume=144 |issue= 11 |pages= 4235–41 |year= 1990 |pmid= 1971295 |doi=
*cite journal | author=Renauld JC, Goethals A, Houssiau F, "et al." |title=Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. |journal=Cytokine |volume=2 |issue= 1 |pages= 9–12 |year= 1991 |pmid= 2129501 |doi=
*cite journal | author=Yang YC, Ricciardi S, Ciarletta A, "et al." |title=Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40. |journal=Blood |volume=74 |issue= 6 |pages= 1880–4 |year= 1989 |pmid= 2508790 |doi=
*cite journal | author=Yin T, Keller SR, Quelle FW, "et al." |title=Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases. |journal=J. Biol. Chem. |volume=270 |issue= 35 |pages= 20497–502 |year= 1995 |pmid= 7544789 |doi=
*cite journal | author=Postma DS, Bleecker ER, Amelung PJ, "et al." |title=Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. |journal=N. Engl. J. Med. |volume=333 |issue= 14 |pages= 894–900 |year= 1995 |pmid= 7666875 |doi=
*cite journal | author=Le Beau MM, Espinosa R, Neuman WL, "et al." |title=Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5484–8 |year= 1993 |pmid= 8516290 |doi=
*cite journal | author=Demoulin JB, Uyttenhove C, Van Roost E, "et al." |title=A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4710–6 |year= 1996 |pmid= 8756628 |doi=
*cite journal | author=Nicolaides NC, Holroyd KJ, Ewart SL, "et al." |title=Interleukin 9: a candidate gene for asthma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 13175–80 |year= 1998 |pmid= 9371819 |doi=
*cite journal | author=Demoulin JB, Van Roost E, Stevens M, "et al." |title=Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25855–61 |year= 1999 |pmid= 10464327 |doi=
*cite journal | author=Lejeune D, Demoulin JB, Renauld JC |title=Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling. |journal=Biochem. J. |volume=353 |issue= Pt 1 |pages= 109–116 |year= 2001 |pmid= 11115404 |doi=
*cite journal | author=Little FF, Cruikshank WW, Center DM |title=Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. |journal=Am. J. Respir. Cell Mol. Biol. |volume=25 |issue= 3 |pages= 347–52 |year= 2001 |pmid= 11588013 |doi=
*cite journal | author=Toda M, Tulic MK, Levitt RC, Hamid Q |title=A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 246–50 |year= 2002 |pmid= 11842292 |doi=
*cite journal | author=Pilette C, Ouadrhiri Y, Van Snick J, "et al." |title=IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta. |journal=J. Immunol. |volume=168 |issue= 8 |pages= 4103–11 |year= 2002 |pmid= 11937570 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Interleukin 6 — (interferon, beta 2) PDB rendering based on 1ALU …   Wikipedia

  • Interleukin-2 — Bändermodell nach PDB  …   Deutsch Wikipedia

  • Interleukin-6 — Bändermodell nach PDB  …   Deutsch Wikipedia

  • Interleukin 10 — Bändermodell nach PDB  …   Deutsch Wikipedia

  • Interleukin 6 — Kristallstruktur Interleukin 6 (kurz: IL 6, synonyme ältere Bezeichnungen: Interferon β2 (IFNB2), B Zell stimulierender Faktor, B Zell Differenzierungs Faktor, Leberzell stimulierender Faktor) gehört zu den Interleukinen (bzw. umfassender zu den… …   Deutsch Wikipedia

  • Interleukin 7 — (IL7) is a hematopoietic growth factor secreted by the stromal cells of the red marrow and thymus capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B cell maturation, T… …   Wikipedia

  • Interleukin 11 — (IL 11) is a multifunctional cytokine first isolated in 1990 from bone marrow derived stromal cells. It is a key regulator of multiple events in hemtaopoiesis, most notably the stimulation of megakaryocyte maturation.cite journal | author = Paul… …   Wikipedia

  • Interleukin 2 — (IL 2) is an interleukin, a type of cytokine immune system signaling molecule, that is instrumental in the body s natural response to microbial infection and in discriminating between foreign (non self) and self. IL 2 mediates its effects by… …   Wikipedia

  • Interleukin-1β — Vorhandene Strukturdaten: s. UniProt Masse/Länge …   Deutsch Wikipedia

  • Interleukin 8 — (IL 8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL 8 in their storage vesicles, the Weibel Palade bodies [Wolff B, Burns AR, Middleton J, Rot A …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.