Nialamide


Nialamide
Nialamide
Systematic (IUPAC) name
N-benzyl-3-(N'-(pyridine-4-carbonyl)hydrazino)propanamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 51-12-7
ATC code N06AF02
PubChem CID 4472
DrugBank DB04820
ChemSpider 4317 YesY
UNII T2Q0RYM725 YesY
KEGG D07337 YesY
Chemical data
Formula C16H18N4O2 
Mol. mass 298.34 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Nialamide (Niamid) is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic. Along with phenelzine and isocarboxazid, it is one of the few hydrazine MAOIs still in clinical use.[citation needed]

Contents

Indications

Depression

Nialamide

Miscellaneous

Nialamide is sometimes used in the treatment of trigeminal neuralgia, generalized anxiety disorder and social phobia. It has also been studied for alcoholism,[1] dermatomally distributed vitiligo,[2] irregular menstruation,[3] angina,[4] cerebrovascular disorders,[5] and the prevention of streptomycin-induced deafness.[6]

Side effects

Side effects on central nervous system include euphoria, psychomotor agitation, insomnia, anxiety, headache, vertigo, tremor, hyperreflexia, manic state, or turnig a depression into mania in bipolar disorder. Other side effects are arterial hypotension, orthostatic hypotension, arterial hypertension, palpitations, hyperhidrosis, dry mouth, nausea, vomiting, epigastric pain, constipation, vision problems, retrobulbar optic neuritis, polyneuritis, weight gain, acute cardiac insufficiency, tachycardia, peripheral neuropathy, jaundice, hepatomegaly, hyperbilirubinemia, urinary retention, elevated transaminases, cutaneous eruptions, impotence, and delayed ejaculation. Dangerous side effects are drug-induced hepatitis and hepatocellular insufficiency.

See also

References

  1. ^ Bobrov AE, Shurygin AN, Krasil'nikov SB (1991). "[Effectiveness of combined use of monoamine oxidase inhibitors and psychotherapy in the treatment of chronic alcoholism]". Zhurnal Nevropatologii i Psikhiatrii Imeni SS Korsakova. 91 (2): 79–83. PMID 1647635. 
  2. ^ Koga M (1977). "Vitiligo: a new classification and therapy". British Journal of Dermatology 97 (3): 255–61. doi:10.1111/j.1365-2133.1977.tb15180.x. PMID 921895. 
  3. ^ Gautray JP, Jolivet A (1976). "[Neuroendocrine investigation and therapy of the menstrual cycle disorders (author's transl)(proceedings)]". Annales d'Endocrinologie 37 (4): 293–4. PMID 1022189. 
  4. ^ Barats SS, Oranskii IE, Kartashova DI, Gorovater EN (1976). "[Comparative clinico-physiological study of the effect of several MAO inhibitors in stenocardia]". Kardiologiia 16 (3): 138–40. PMID 1021625. 
  5. ^ Mirzoian RS (1975). "[Prevention of cerebrovascular disorders with adrenergic substances]". Biulleten' Eksperimental'noi Biologii i Meditsiny 80 (11): 50–3. PMID 1218262. 
  6. ^ Semczuk B, Klonowski S, Golabek W (1974). "The protective effect of niamid on hearing in patients treated with large doses of streptomycin". Annales Universitatis Mariae Curie-Sklodowska Sectio D: Medicina 29 (1): 193–7. PMID 4467804. 



Wikimedia Foundation. 2010.

Look at other dictionaries:

  • nialamide — noun Etymology: nicotinic acid + amyl + amide Date: 1959 a synthetic antidepressant drug C16H18N4O2 that is an inhibitor of monoamine oxidase …   New Collegiate Dictionary

  • nialamide — noun A monoamine oxidase inhibitor antidepressant, chemically related to iproniazide …   Wiktionary

  • nialamide — A monoamine oxidase inhibitor used in the treatment of depressive disorders. * * * ni·al·amide nī al ə .mīd n a synthetic antidepressant drug C16H18N4O2 that is an inhibitor of monoamine oxidase …   Medical dictionary

  • nialamide — ni·al·amide …   English syllables

  • nialamide — nīˈaləˌmīd, mə̇d noun Etymology: nicotinic acid + amyl + amide : a synthetic antidepressant drug C16H18N4O2 that is an inhibitor of monoamine oxidase …   Useful english dictionary

  • Metfendrazine — Systematic (IUPAC) name 1 methyl 1 (1 methyl 2 phenyl ethyl)hydrazine Clinical data Pregnancy cat.  ? …   Wikipedia

  • Hydrazine (antidepressant) — Iproniazid, the first hydrazine MAOI to be discovered, and the first antidepressant drug ever marketed. The hydrazine antidepressants are a group of non selective and irreversible monoamine oxidase inhibitors (MAOIs) that were discovered and… …   Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Phenelzine — Systematic (IUPAC) name (±) 2 phenylethylhydrazine …   Wikipedia

  • Empathogen-entactogen — The terms empathogen and entactogen are used to describe a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA. Putative members of this class include 2C B, 2C I, MDMA, MDA, MDEA, MBDB, 2C T… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.