Systematic (IUPAC) name
Clinical data
Pregnancy cat.  ?
Legal status  ?
CAS number 64-12-0
ATC code  ?
PubChem CID 3127
ChemSpider 3015 YesY
Chemical data
Formula C9H12ClN 
Mol. mass 169.651
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

para-Chloroamphetamine (PCA), also known as 4-chloroamphetamine (4-CA), is an amphetamine derivative and monoamine releaser similar to MDMA, but with substantially higher neurotoxicity, thought to be due to the unrestrained release of both serotonin and dopamine as with MDMA itself.[1] It is used as a neurotoxin by neurobiologists to selectively kill serotonergic neurons for research purposes, in the same way that 6-hydroxydopamine is used to kill dopaminergic neurons.[2][3][4][5]

This compound does have a history of being used daily as an antidepressant in humans with no mentionable side effects that are particularly worrysome. However, the effects of the compound on experimental animals appear less encouraging.[6]

See also


  1. ^ Johnson MP, Huang XM, Oberlender R, Nash JF, Nichols DE. Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. European Journal of Pharmacology. 1990 Nov 20;191(1):1-10. PMID 1982656
  2. ^ Gal EM, Cristiansen PA, Yunger LM. Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in vivo: a reexamination. Neuropharmacology. 1975 Jan;14(1):31-9. PMID 125387
  3. ^ Curzon G, Fernando JC, Marsden CA. 5-Hydroxytryptamine: the effects of impaired synthesis on its metabolism and release in rat. British Journal of Pharmacology. 1978 Aug;63(4):627-34. PMID 80243
  4. ^ Colado MI, Murray TK, Green AR. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. British Journal of Pharmacology. 1993 Mar;108(3):583-9. PMID 7682129
  5. ^ Freo U, Pietrini P, Pizzolato G, Furey M, Merico A, Ruggero S, Dam M, Battistin L. Cerebral metabolic responses to clomipramine are greatly reduced following pretreatment with the specific serotonin neurotoxin para-chloroamphetamine (PCA). A 2-deoxyglucose study in rats. Neuropsychopharmacology. 1995 Nov;13(3):215-22. PMID 8602894
  6. ^

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • para-Iodoamphetamine — Systematic (IUPAC) name 1 (4 iodophenyl)propan 2 amine Clinical data Pregnancy cat.  ? …   Wikipedia

  • 2,5-Dimethoxy-4-chloroamphetamine — Systematic (IUPAC) name 1 (4 chloro 2,5 dimethoxy phenyl)propan 2 amine Clinical data Pr …   Wikipedia

  • 4-Chloramphetamin — Strukturformel Allgemeines Name 4 Chloramphetamin Andere Namen …   Deutsch Wikipedia

  • Substituted amphetamine — Optical isomers of amphetamine D amphetamine …   Wikipedia

  • Releasing agent — Amphetamine, the prototypical releasing agent, which acts on norepinephrine and dopamine. A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading… …   Wikipedia

  • 6-CAT — Systematic (IUPAC) name 6 chloro 2 aminotetralin Clinical data Pregnancy cat.  ? …   Wikipedia

  • PCA — or PCa may refer to: Contents 1 Organizations 1.1 Education 1.2 Trade …   Wikipedia

  • Fenclonine — Systematic (IUPAC) name (S) 2 amino 3 (4 chlorophenyl)propanoic acid Clinical data Pregnancy cat.  ? …   Wikipedia

  • 4-Fluoroamphetamine — Drugbox IUPAC name = 1 (4 Fluorophenyl)propan 2 amine width = 200px CAS number= 459 02 9 ATC prefix= ATC suffix= PubChem= 9986 DrugBank= C=9 | H=12 | F=1 | N=1 C=9|H=12|F=1|N=1 molecular weight = 153.20 g/mol bioavailability= metabolism =… …   Wikipedia

  • DOx — 2,5 Dimethoxyamphetamine (2,5 DMA), the base structure of the DOx family. DOx is a term used to refer to a chemical class of substituted amphetamine derivatives featuring methoxy groups at the 2 and 5 positions of the phenyl ring, and a… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.