Sodium–hydrogen antiporter 3

Solute carrier family 9 (sodium/hydrogen exchanger), member 3
Identifiers
Symbols SLC9A3; MGC126718; MGC126720; NHE3
External IDs OMIM182307 MGI105064 HomoloGene55804 GeneCards: SLC9A3 Gene
RNA expression pattern
PBB GE SLC9A3 207212 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6550 105243
Ensembl ENSG00000066230 ENSMUSG00000036123
UniProt P48764 n/a
RefSeq (mRNA) NM_004174.2 NM_001081060.1
RefSeq (protein) NP_004165.2 NP_001074529.1
Location (UCSC) Chr 5:
0.47 – 0.52 Mb
Chr 13:
74.26 – 74.3 Mb
PubMed search [1] [2]

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.[1][2]

SLC9A3 is a sodium–hydrogen antiporter. It is found in the nephron of the kidney and in the apical membrane of enterocytes of the intestine. It is primarily responsible for maintaining the balance of sodium.[3]

Contents

Regulation

Protein kinase C stimulates NHE3, while protein kinase A inhibits it. [4]

There is a specific protein functioning as an NHE3 regulator, Sodium-hydrogen antiporter 3 regulator 1.

Interactions

Sodium-hydrogen antiporter 3 has been shown to interact with CHP.[5]

References

  1. ^ "Entrez Gene: SLC9A3 Solute carrier family 9 (sodium/hydrogen exchanger), member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6550. 
  2. ^ Brant SR, Bernstein M, Wasmuth JJ, Taylor EW, McPherson JD, Li X, Walker S, Pouyssegur J, Donowitz M, Tse CM (March 1993). "Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3". Genomics 15 (3): 668–72. doi:10.1006/geno.1993.1122. PMID 8096830. 
  3. ^ VI. Mechanisms of Salt & Water Reabsorption
  4. ^ 852 Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3.  Page 852
  5. ^ Inoue, Hiroki; Nakamura Yutaka, Nagita Mana, Takai Tomoyo, Masuda Miho, Nakamura Norihiro, Kanazawa Hiroshi (Feb. 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. (Japan) 26 (2): 148–55. doi:10.1248/bpb.26.148. ISSN 0918-6158. PMID 12576672. 

Further reading

  • McDonough AA, Leong PK, Yang LE (2003). "Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport.". Ann. N. Y. Acad. Sci. 986: 669–77. doi:10.1111/j.1749-6632.2003.tb07281.x. PMID 12763917. 
  • Orlowski J, Kandasamy RA, Shull GE (1992). "Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.". J. Biol. Chem. 267 (13): 9331–9. PMID 1577762. 
  • Brant SR, Yun CH, Donowitz M, Tse CM (1995). "Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.". Am. J. Physiol. 269 (1 Pt 1): C198–206. PMID 7631746. 
  • Colombani V, Silviani V, Marteau C, et al. (1996). "Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder.". Clin. Sci. 91 (2): 209–12. PMID 8795445. 
  • Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774. 
  • Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38044. 
  • Yun CH, Lamprecht G, Forster DV, Sidor A (1998). "NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin.". J. Biol. Chem. 273 (40): 25856–63. doi:10.1074/jbc.273.40.25856. PMID 9748260. 
  • Biemesderfer D, Nagy T, DeGray B, Aronson PS (1999). "Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule.". J. Biol. Chem. 274 (25): 17518–24. doi:10.1074/jbc.274.25.17518. PMID 10364184. 
  • Mobasheri A, Golding S, Pagakis SN, et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts.". Cell Biol. Int. 22 (7–8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823. 
  • Trujillo E, Alvarez de la Rosa D, Mobasheri A, et al. (1999). "Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes.". Histol. Histopathol. 14 (4): 1023–31. PMID 10506918. 
  • Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268. 
  • Malakooti J, Memark VC, Dudeja PK, Ramaswamy K (2002). "Molecular cloning and functional analysis of the human Na(+)/H(+) exchanger NHE3 promoter.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G491–500. doi:10.1152/ajpgi.00273.2001. PMID 11841999. 
  • Gekle M, Serrano OK, Drumm K, et al. (2002). "NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis.". Am. J. Physiol. Renal Physiol. 283 (3): F549–58. doi:10.1152/ajprenal.00206.2001. PMID 12167607. 
  • Kennedy DJ, Leibach FH, Ganapathy V, Thwaites DT (2003). "Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity.". Pflugers Arch. 445 (1): 139–46. doi:10.1007/s00424-002-0910-1. PMID 12397398. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
  • Lee SH, Seok YS, Jung HH, et al. (2003). "Expression of mRNA transcripts of the Na+/H+ and Cl-/HCO3- exchanger isoforms in human nasal mucosa.". Acta Otolaryngol. 122 (8): 866–71. doi:10.1080/003655402/000028045. PMID 12542207. 
  • Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 

External links

P-type ATPase (3.A.3)
  • 3.A.3.1.4: H+/K+ transporting, nongastric: ATP12A

Other/ungrouped:

Na+/K+ - H+

  • Mg++ transporting: ATP3
  • Class I, type 8: ATP8A1, ATP8B1, ATP8B2, ATP8B3, ATP8B4
  • Class II, type 9: ATP9A, ATP9B
  • Class V, type 10: ATP10A, ATP10B, ATP10D
  • Class VI, type 11: ATP11A, ATP11B, ATP11C
  • type 13: ATP13A1, ATP13A2, ATP13A3, ATP13A4, ATP13A5
see also ATPase disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Sodium-hydrogen antiporter 3 — or Sodium hydrogen exchanger 3 (NHE3) is an isoform of sodium hydrogen antiporters. It is found in the nephron of the kidney and is primarily responsible for maintaining the balance of sodium. [ [http://www2.kumc.edu/ki/physiology/course/six/6… …   Wikipedia

  • Sodium–hydrogen antiporter — The sodium–hydrogen antiporter or sodium–hydrogen exchanger is a membrane protein found in many cells, and especially in those of the nephron of the kidney. It is primarily responsible for maintaining the balance of sodium.[1] Isoforms There are… …   Wikipedia

  • Sodium-hydrogen antiporter 1 — The Sodium hydrogen antiporter 1 is an isoform of sodium hydrogen antiporters.ClassificationIt is a solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) , GeneIt is encoded by the gene SLC9A1 .… …   Wikipedia

  • Sodium-hydrogen antiporter — protein Name = solute carrier family 9 (sodium/hydrogen exchanger), member 3 caption = width = HGNCid = 11073 Symbol = SLC9A3 AltSymbols = NHE3 EntrezGene = 6550 OMIM = 182307 RefSeq = NM 004174 UniProt = P48764 PDB = ECnumber = Chromosome = 5… …   Wikipedia

  • Sodium-hydrogen antiporter 3 regulator 1 — Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 PDB rendering based on 1g9o …   Wikipedia

  • Sodium-hydrogen exchange regulatory cofactor 2 — Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 PDB rendering based on 2he4 …   Wikipedia

  • Standard hydrogen electrode — NHE redirects here. For the sodium hydrogen exchanger protein, see Sodium hydrogen antiporter. The standard hydrogen electrode (abbreviated SHE), is a redox electrode which forms the basis of the thermodynamic scale of oxidation reduction… …   Wikipedia

  • List of biochemistry topics — This page aims to list articles on Wikipedia that are related to biochemistry. This is so that those interested in the subject can monitor changes to the pages by clicking on .This list is not necessarily complete or up to date if you see an… …   Wikipedia

  • Amiloride — Systematic (IUPAC) name 3,5 diamino 6 chloro N …   Wikipedia

  • МВТР — Обозначения Символы CFTR; CF, ABCC7 …   Википедия

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.