NAN-190

NAN-190
Systematic (IUPAC) name
1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 115388-32-4 YesY
ATC code  ?
PubChem CID 4431
IUPHAR ligand 73
ChEMBL CHEMBL8618 N
Chemical data
Formula C23H27N3O3 
Mol. mass 393.478 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

NAN-190 is a drug and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor antagonist, but a subsequent discovery showed that it also potently blocks the α2-adrenergic receptor.[1] The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin receptor antagonist.[1]

References

  1. ^ a b Foong JP, Bornstein JC. (2009). "5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig.". Neuroreport. 20 (3): 325–330. doi:10.1097/WNR.0b013e3283232caa. PMID 19190523. 

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