Morazone


Morazone
Morazone
Systematic (IUPAC) name
1,5-dimethyl-4-[(3-methyl-2-phenylmorpholin-4-yl)methyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
Clinical data
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral, SC, IM[1]
Identifiers
CAS number 6536-18-1 N
ATC code None
PubChem CID 39609
ChemSpider 36216 YesY
UNII 870Q5BL2FN YesY
Chemical data
Formula C23H27N3O2 
Mol. mass 377.48 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Morazone (Novartrina, Orsimon, Rosimon-Neu, Tarcuzate) is a non-steroidal anti-inflammatory drug (NSAID) originally developed by the German pharmaceutical company Ravensberg in the 1950s.[2] Morazone is used as an analgesic.[1][3] It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.[4][5][6][7]

See also

References

  1. ^ a b Seyffart, G. (1991). Drug dosage in renal insufficiency. Boston: Kluwer Academic Publishers. pp. 399. ISBN 0-7923-0964-2. http://books.google.com/books?id=FubgMz6aOWAC&lpg=PA399&dq=morazone&pg=PA399#v=onepage&q=&f=false. 
  2. ^ US patent 2943022, Siemer, H. & Doppstadt, A., "Substituted l-phenyl-2,3-dimethyl-4-morpholino methyl pyrazolone-(S) Compounds and Process of making same", issued 1960-06-28, assigned to Ravensberg 
  3. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 4659. ISBN 0-412-54090-8. http://books.google.com/books?id=r7z8W69GcoMC&lpg=PA4659&pg=PA4659#v=onepage&q=&f=false. 
  4. ^ Bohn, G.; Rücker, G.; Kröger, H. (1976). "Investigations of the decomposition and detection of morazone by thin-layer- and gas-liquid-chromatography". Archives of toxicology 35 (3): 213–220. PMID 989292.  edit
  5. ^ Neugebauer, M. (1984). "Some new urinary metabolites of famprofazone and morazone in man". Journal of pharmaceutical and biomedical analysis 2 (1): 53–60. PMID 16867765.  edit
  6. ^ Kingreen, J. C.; Breger, G. (1984). "Pellagra in morazone abuse". Zeitschrift für Hautkrankheiten 59 (9): 573–577. PMID 6145264.  edit
  7. ^ Daunderer, M.; Janzen, W. (1972). "Rosimon-NEU--a non-prescription analgesic on the adolescent drug scene". Beiträge zur gerichtlichen Medizin 29: 138–143. PMID 5081964.  edit

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