miR-338 Conserved secondary structure of miR-338 microRNA precursor Identifiers Symbol miR-338 Alt. Symbols MIR338 Rfam RF00686 miRBase MI0000814 miRBase family MIPF0000097 Entrez 442906 HUGO 31775 OMIM 614059 RefSeq NR_029897 Other data RNA type miRNA Domain(s) Mammalia GO 0035195 SO 0001244 Locus Chr. 17 q25.3
miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precusor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.
miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4). The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.
miR-338 is dysregulated in neuroblastoma, and could potentially be implemented as a biomarker or future therapeutic agent. miR-338 has also been linked with hepatocellular carcinoma, and a large-scale diagnostic test has been suggested involving measurement of miR-338 expression in tissue samples. Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer.
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- ^ Barik, S (2008 Sep). "An intronic microRNA silences genes that are functionally antagonistic to its host gene.". Nucleic acids research 36 (16): 5232–41. PMID 18684991.
- ^ a b Kaplan, BB; Gioio, AE, Hillefors, M, Aschrafi, A (2009). "Axonal protein synthesis and the regulation of local mitochondrial function.". Results and problems in cell differentiation 48: 225–42. PMID 19343315.
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- ^ Huang, XH; Wang, Q, Chen, JS, Fu, XH, Chen, XL, Chen, LZ, Li, W, Bi, J, Zhang, LJ, Fu, Q, Zeng, WT, Cao, LQ, Tan, HX, Su, Q (2009 Aug). "Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated.". Hepatology research : the official journal of the Japan Society of Hepatology 39 (8): 786–94. PMID 19473441.
- ^ Li, X; Zhang, Y, Zhang, Y, Ding, J, Wu, K, Fan, D (2010 May). "Survival prediction of gastric cancer by a seven-microRNA signature.". Gut 59 (5): 579–85. PMID 19951901.
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- Saba, R; Goodman, CD, Huzarewich, RL, Robertson, C, Booth, SA (2008). "A miRNA signature of prion induced neurodegeneration.". PloS one 3 (11): e3652. PMID 18987751.
miRNA precursor families 1-100 101-200 201+ Other
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