Systematic (IUPAC) name
Clinical data
Pregnancy cat.  ?
Legal status Controlled under Federal Analog Act
CAS number 3398-68-3
ATC code  ?
PubChem CID 90766
Chemical data
Formula C11H17NO 
Mol. mass 179.259 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

para-Methoxymethamphetamine (PMMA), is a stimulant drug related to para-methoxyamphetamine (PMA).

8 pills of PMMA recovered by the DEA

PMMA reputedly produces similar effects to PMA, but is apparently slightly more similar to MDMA in effects[1][2] and has slightly less tendency to produce severe hyperthermia, at least at low doses. At higher doses however the side effects and danger of death are just as severe as those of PMA itself.[3]

PMMA is a lesser-known psychedelic drug. It is the 4-methoxy analog of methamphetamine. PMMA was probably first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), the minimum dosage is listed as 100 mg, and the duration unknown. Shulgin reported that methyl-MA produces an increase in blood pressure and in heart rate, but causes no psychoactive effects, however user reports following the subsequent appearance of this drug on the illicit market as an analogue of "Ecstasy" (MDMA) suggest that PMMA does produce some empathogenic effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of PMMA, and given the known toxicity of the related compound PMA it is likely to have considerable potential to cause harmful side effects or overdose which can be fatal.[4]


Reported deaths

31 January 2011 the Norwegian Broadcasting Corporation reported that Norway had seen a staggering 12 deaths related to this drug in just 6 months.

31 March 2011 Dutch media reported that the Netherlands (Limburg province) had seen 4 deaths related to this drug since November 2010.[5]

30 April 2011 Icelandic media reported that Iceland had seen 1 death of a young woman that may have been related to this drug.

See also

External links


  1. ^ Glennon, RA; Young, R; Dukat, M; Cheng, Y (1997). "Initial characterization of PMMA as a discriminative stimulus". Pharmacology, biochemistry, and behavior 57 (1-2): 151–8. doi:10.1016/S0091-3057(96)00306-1. PMID 9164566. 
  2. ^ Rangisetty, JB; Bondarev, ML; Chang-Fong, J; Young, R; Glennon, RA (2001). "PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA". Pharmacology, biochemistry, and behavior 69 (1-2): 261–7. doi:10.1016/S0091-3057(01)00530-5. PMID 11420094. 
  3. ^ Johansen, SS; Hansen, AC; Müller, IB; Lundemose, JB; Franzmann, MB (2003). "Three fatal cases of PMA and PMMA poisoning in Denmark". Journal of analytical toxicology 27 (4): 253–6. PMID 12820749. 
  4. ^ Becker, J; Neis, P; Röhrich, J; Zörntlein, S (2003). "A fatal paramethoxymethamphetamine intoxication". Legal medicine (Tokyo, Japan). 5 Suppl 1: S138–41. PMID 12935573. 
  5. ^ "PMMA deaths in Holland". Retrieved 8 June 2011.