Carboplatin, an example of a metallopharmaceutical

A metallopharmaceutical is a drug that contains a metal as an active ingredient.[1][2] Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents.

Examples of metallopharmaceuticals include:


  1. ^ Guo J, Sadler PJ (1999). "Medicinal Inorganic Chemistry". Adv. Inorg. Chem. 49: 183–306. doi:10.1016/S0898-8838(08)60271-8. 
  2. ^ Ray S, Mohan R, Singh JK, Samantaray MK, Shaikh MM, Panda D, Ghosh P (December 2007). "Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes". J. Am. Chem. Soc. 129 (48): 15042–53. doi:10.1021/ja075889z. PMID 17988129. 
  3. ^ Fischbach L, Evans EL (August 2007). "Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori". Aliment. Pharmacol. Ther. 26 (3): 343–57. doi:10.1111/j.1365-2036.2007.03386.x. PMID 17635369. 
  4. ^ Graham DY, Shiotani A (June 2008). "New concepts of resistance in the treatment of Helicobacter pylori infections". Nat. Clin. Pract. Gastroenterol. Hepatol. 5 (6): 321–31. doi:10.1038/ncpgasthep1138. PMC 2841357. PMID 18446147. 
  5. ^ Lokich J, Anderson N (January 1998). "Carboplatin versus cisplatin in solid tumors: an analysis of the literature". Ann. Oncol. 9 (1): 13–21. doi:10.1023/A:1008215213739. PMID 9541678. 
  6. ^ Go RS, Adjei AA (January 1999). "Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin". J. Clin. Oncol. 17 (1): 409–22. PMID 10458260. 
  7. ^ Messori L, Marcon G (2004). "Gold complexes in the treatment of rheumatoid arthritis". Met. Ions Biol. Syst. 41: 279–304. PMID 15206120. 
  8. ^ Gaujoux-Viala C, Smolen JS, Landewé R, Dougados M, Kvien TK, Mola EM, Scholte-Voshaar M, van Riel P, Gossec L (June 2010). "Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis". Ann. Rheum. Dis. 69 (6): 1004–9. doi:10.1136/ard.2009.127225. PMID 20447954. 
  9. ^ Fuller FW (2009). "The side effects of silver sulfadiazine". J. Burn Care Res. 30 (3): 464–70. doi:10.1097/BCR.0b013e3181a28c9b. PMID 19349889. 
  10. ^ Carter MJ, Tingley-Kelley K, Warriner RA (October 2010). "Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta-analysis". J. Am. Acad. Dermatol. 63 (4): 668–79. doi:10.1016/j.jaad.2009.09.007. PMID 20471135. 
  11. ^ Guthery E, Seal LA, Anderson EL (February 2005). "Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects". Am. J. Infect. Control 33 (1): 15–22. doi:10.1016/j.ajic.2004.07.012. PMID 15685130. 

Further reading

  • Bonett A, Leone R, Muggia R, Howell SB, ed (2008). Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. Humana Press. ISBN 9781603274586. 
  • Clarke MJ, Sadler PJ (1999). Metallopharmaceuticals: Diagnosis and therapy. Springer. ISBN 9783540653080. 
  • Clarke MJ, Sadler PJ (1999). Metallopharmaceuticals I: DNA Interactions. Springer. ISBN 9783540648895. 
  • Gielen M, Tiekink ERT, ed (2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN 9780470864036. 
  • Jones CJ, Thornback J (2007). Medicinal Applications of Coordination Chemistry. RSC Publishing. ISBN 9780854045969.