Drug-induced autoimmune hemolytic anemia

Drug-induced autoimmune hemolytic anemia
Classification and external resources
ICD-10 D59.0
ICD-9 283

Drug-induced autoimmune hemolytic anemia is a form of hemolytic anemia.

Penicillin in high doses can induce immune mediated hemolysis[1] via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.

The drug itself can be targeted by the immune system, e.g. by IgE in a Type I hypersensitivity reaction to penicillin, rarely leading to anaphylaxis.

See also

  • List of circulatory system conditions
  • List of hematologic conditions


  1. ^ Stroncek D, Procter JL, Johnson J (May 2000). "Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction". Am. J. Hematol. 64 (1): 67–70. doi:10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z. PMID 10815791. 

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