- Diet and attention deficit hyperactivity disorder
For some children, diet is suspected of playing a role in the multiple behavioral and cognitive symptoms of attention deficit hyperactivity disorder (ADHD). Concerns have focused on food additives, blood sugar regulation, food allergies and intolerances, and vitamin, mineral and fatty acid deficiencies.
Pediatrician Benjamin Feingold claimed a link between artificial dyes, preservatives, and ADHD in the 1970s. He proposed the Feingold diet as a solution, which eliminates certain processed foods and food additives as well as certain fruits and vegetables.
In September 2007, research financed by Britain’s Food Standards Agency and published online by the British medical journal The Lancet presented evidence that a mix of additives commonly found in children’s foods increases the mean level of hyperactivity.
The team of researchers concluded that “the finding lends strong support for the case that food additives exacerbate hyperactive behaviors (inattention, impulsivity and overactivity) at least into middle childhood.”[cite this quote] That study examined the effect of artificial colors and a sodium benzoate preservative, and found both to be problematic for some children. Further studies are needed to find out whether there are other additives that could have a similar effect, and it is unclear whether some disturbances can also occur in mood and concentration in some adults. In the February 2008 issue of its publication, AAP Grand Rounds, the American Academy of Pediatrics concluded that a low-additive diet is a valid intervention for children with ADHD:
Although quite complicated, this was a carefully conducted study in which the investigators went to great lengths to eliminate bias and to rigorously measure outcomes. The results are hard to follow and somewhat inconsistent. For many of the assessments there were small but statistically significant differences of measured behaviors in children who consumed the food additives compared with those who did not. In each case increased hyperactive behaviors were associated with consuming the additives. For those comparisons in which no statistically significant differences were found, there was a trend for more hyperactive behaviors associated with the food additive drink in virtually every assessment. Thus, the overall findings of the study are clear and require that even we skeptics, who have long doubted parental claims of the effects of various foods on the behavior of their children, admit we might have been wrong.[cite this quote]
Several other recent studies have renewed interest in whether certain foods and additives might affect particular symptoms in a subset of children with ADHD.
As of mid-2009, the consensus on a sensible approach to nutrition for children with ADHD is the same recommended for all children: eat a diet that emphasizes fruits and vegetables, whole grains, healthful unsaturated fats, and good sources of protein; go easy on unhealthy saturated and trans fats, rapidly digested carbohydrates, and fast food; and balance healthy eating with plenty of physical activity. (Emphasis added) 
As yet there is no consensus about how such additives might contribute to ADHD symptoms in children. In a recent well-designed study in Britain, the investigators found a mild but significant increase in hyperactivity in both age[clarification needed] groups of children—across the board, regardless of baseline hyperactivity levels—during the weeks when they consumed drinks containing artificial colors. This study concluded that the additives might explain about 10% of the behavioral difference between a child with ADHD and one without the disorder.
An earlier meta-analysis conducted at Columbia University and Harvard University suggests that removing these agents from the diets of children with ADHD would be about one-third to one-half as effective as treatment with methylphenidate (Ritalin).
Authors of both of these studies cautioned that only a minority of children are particularly vulnerable to the effects of artificial additives. They also pointed out that determining which children are susceptible is difficult, though not impossible.
The European Food Safety Authority (EFSA) reviewed the literature on the association between food additives and hyperactivity and concluded that there is only limited evidence of an association between the intake of additives and activity and attention and then only in some children studied. They further indicated that the effects reported in the study were not consistent for the two age groups and for the two food additive mixtures used in the study. Others have suggested a trial of removing additives from the diet for children with ADHD as it is harmless and might be helpful.
As of March 2011, the FDA was evaluating the scientific evidence of a link between dyes and ADHD; a preliminary analysis found there was no link.
A number of studies have found that sucrose (sugar) has no effect on behavior and in particular it does not exacerbate the symptoms of children diagnosed with ADHD. One study demonstrated the impact of expectancy effects in parents' perceptions of their children's hyperactivity after consuming sugar. In this study, parents who were told their child had ingested a high concentration of sugar in drink form (even though the drink was actually flavored with aspartame), reported their child as being more active, inattentive and resistant to parental demands. This was in comparison to the group who were told (accurately) that their child had ingested no sugar.
Omega-3 fatty acids
Some research suggests that children with ADHD may have low blood levels of essential omega-3 fatty acids. However, it is unknown if decreased blood levels of omega-3 fatty acids can cause or exacerbate ADHD or whether lower blood levels of omega-3 fatty acids associated with ADHD are caused by an underlying mechanism. Fish oils appear to reduce ADHD-related symptoms in some children. A double blind study has showed "medium to strong treatment effects of omega 3 fatty acids on symptoms of ADHD" after administering amounts around 1 gram for three to six months.Several other studies showed similar effects, especially of Omega 3 fatty acids with Zinc and Magnesium.
- ^ a b "FDA Probes Link Between Food Dyes, Kids' Behavior". http://www.npr.org/2011/03/30/134962888/fda-probes-link-between-food-dyes-kids-behavior. Retrieved 2011-04-09.
- ^ McCann D, Barrett A, Cooper A, et al. (November 2007). "Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial". Lancet 370 (9598): 1560–7. doi:10.1016/S0140-6736(07)61306-3. PMID 17825405.
- ^ a b c d e "Diet and attention deficit hyperactivity disorder. Can some food additives or nutrients affect symptoms? The jury is still out". The Harvard Mental Health Letter 25 (12): 4–5. June 2009. PMID 19582942.
- ^ "EFSA evaluates Southampton study on food additives and child behaviour" (Press release). European Food Safety Authority. March 14, 2008. http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178694645855.htm. Retrieved April 22, 2010.
- ^ Kemp A (May 2008). "Food additives and hyperactivity". BMJ 336 (7654): 1144. doi:10.1136/bmj.39582.375336.BE. PMC 2394588. PMID 18497374. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2394588.
- ^ Benton D (May 2008). "Sucrose and behavioral problems". Critical Reviews in Food Science and Nutrition 48 (5): 385–401. doi:10.1080/10408390701407316. PMID 18464029.
- ^ "What Causes ADHD?". Attention Deficit Hyperactivity Disorder. United States Department of Health and Human Services. 2008. http://www.nimh.nih.gov/health/publications/attention-deficit-hyperactivity-disorder/complete-index.shtml#pub3. Retrieved April 22, 2010.
- ^ Staudenmayer, Herman (1999). Environmental Illness: Myth and Reality. CRC Press. pp. 58–62. ISBN 1-56670-305-0.
- ^ Hoover, D.W. & Milich, R. (1994). The effects of sugar ingestion expectancies on mother-child interactions, Journal of Abnormal Child Psychology, 22, 501-515.
- ^ a b Young G, Conquer J (2005). "Omega-3 fatty acids and neuropsychiatric disorders". Reproduction, Nutrition, Development 45 (1): 1–28. doi:10.1051/rnd:2005001. PMID 15865053.
- ^ Haag M (April 2003). "Essential fatty acids and the brain". Canadian Journal of Psychiatry 48 (3): 195–203. PMID 12728744.
- ^ Richardson AJ, Montgomery P (May 2005). "The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder". Pediatrics 115 (5): 1360–6. doi:10.1542/peds.2004-2164. PMID 15867048.
- ^ Huss, Michael/Andreas Volp/Manuela Stauss-Grabo, 2010: Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study. In: Lipids in Health and Disease 9, 105. <http://www.lipidworld.com/content/9/1/105>
- ^ N. Sinn, J. Bryan: Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD In: J Dev Behav Pediatr 28, 2007, S. 82–91 doi:10.1097/01.DBP.0000267558.88457.a5. PMID 17435458.
- ^ J. Frölich, M. Döpfner: Die Behandlung von Aufmerksamkeitsdefizit-/Hyperaktivitätsstörungen mit mehrfach ungesättigten Fettsäuren – eine wirksame Behandlungsoption? In: Z Kinder Jugendpsychiatr Psychother 36, 2008, S. 109–116 doi:10.1024/1422-49184.108.40.206, PMID 18622940.
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