Systematic (IUPAC) name
Clinical data
Pregnancy cat.  ?
Legal status  ?
CAS number 4528-51-2 YesY
ATC code  ?
Chemical data
Formula C13H17N 
Mol. mass 187.28 g/mol
 YesY(what is this?)  (verify)

D-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor, as well as prodrug to D-amphetamine and D-methamphetamine, and therefore a norepinephrine-dopamine releasing agent. It is the opposite enantiomer of L-deprenyl (selegiline). It was discovered by Wander AG in the 1960s[1].

L-Deprenyl, also an MAO-B inhibitor, metabolizes to L-amphetamine and l-methamphetamine, which are selective norepinephrine releasing agents. In contrast, D-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas L-deprenyl is the opposite.[2]

See also


  1. ^ CH Patent 393306 - Verfahren zur Herstellung von tertiären Aminen der Phenylalkylreihe
  2. ^ Yasar S, Gaál J, Panlilio LV et al. (January 2006). "A comparison of drug-seeking behavior maintained by d-amphetamine, l-deprenyl (selegiline) and d-deprenyl under a second-order schedule in squirrel monkeys". Psychopharmacology 183 (4): 413–21. doi:10.1007/s00213-005-0200-7. ISBN 0021300502007. PMC 1360227. PMID 16292593. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1360227.