Volume expander

A volume expander is a type of intravenous therapy that has the function of providing volume for the circulatory system. It may be used for fluid replacement.

Contents

Physiology

When blood is lost, the greatest immediate need is to stop further blood loss. The second greatest need is replacing the lost volume. This way remaining red blood cells can still oxygenate body tissue. Normal human blood has a significant excess oxygen transport capability, only used in cases of great physical exertion. Provided blood volume is maintained by volume expanders, a quiescent patient can safely tolerate very low haemoglobin levels, less than 1/3 that of a healthy person.

The body automatically detects the lower haemoglobin level, and compensatory mechanisms start up. The heart pumps more blood with each beat. Since the lost blood was replaced with a suitable fluid, the now diluted blood flows more easily, even in the small vessels. As a result of chemical changes, more oxygen is released to the tissues. These adaptations are so effective that if only half of the red blood cells remain, oxygen delivery may still be about 75 percent of normal. A patient at rest uses only 25 percent of the oxygen available in his blood. In extreme cases, patients have survived with a haemoglobin level of 2 g/dl, about 1/7 the norm, although levels this low are very dangerous.

With enough blood loss, ultimately red blood cell levels drop too low for adequate tissue oxygenation, even if volume expanders maintain circulatory volume. In these situations, the only alternatives are blood transfusions, packed red blood cells, or oxygen therapeutics (if available). However in some circumstances, hyperbaric oxygen therapy can maintain adequate tissue oxygenation even if red blood cell levels are below normal life-sustaining levels.

Types

There are two main types of volume expanders; crystalloids and colloids. Crystalloids are aqueous solutions of mineral salts or other water-soluble molecules. Colloids contain larger insoluble molecules, such as gelatin; blood itself is a colloid.

Colloids

Colloids preserve a high colloid osmotic pressure in the blood, while, on the other hand, this parameter is decreased by crystalloids due to hemodilution.[1] Therefore, they should theoretically preferentially increase the intravascular volume, whereas crystalloids also increase the interstitial volume and intracellular volume. However, there is still controversy as to the actual difference in efficacy due to this difference in action.[1] Another difference is that crystalloids generally are much cheaper than colloids.[1]

Hydroxyethyl starch

Hydroxyethyl starch (HES/HAES, common trade names: Hespan, Voluven) is one of the most frequently used colloids. An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or some other problem. It increases the blood volume, allowing red blood cells to continue to deliver oxygen to the body.

Crystalloids

The most commonly used crystalloid fluid is normal saline, a solution of sodium chloride at 0.9% concentration, which is close to the concentration in the blood (isotonic). Ringer's lactate or Ringer's acetate is another isotonic solution often used for large-volume fluid replacement. A solution of 5% dextrose in water, sometimes called D5W, is often used instead if the patient is at risk for having low blood sugar or high sodium. The choice of fluids may also depend on the chemical properties of the medications being given.

Intravenous fluids must always be sterile.

Ringer's solution

Lactated Ringer's solution contains 28 mmol/L lactate, 4 mmol/L K+ and 1.5 mmol/L Ca2+. It is very similar - though not identical to - Hartmann's Solution, the ionic concentrations of which differ.

Ringer's acetate consists of 28 mmol/L acetate, 4 mmol/L K+ and 1.5 mmol/L Ca2+.

Normal saline

Normal saline (NS) is the commonly-used term for a solution of 0.91% w/v of NaCl, about 300 mOsm/L.[2] Less commonly, this solution is referred to as physiological saline or isotonic saline, neither of which is technically accurate. NS is used frequently in intravenous drips (IVs) for patients who cannot take fluids orally and have developed or are in danger of developing dehydration or hypovolemia. NS is typically the first fluid used when hypovolemia is severe enough to threaten the adequacy of blood circulation, and has long been believed to be the safest fluid to give quickly in large volumes. However, it is now known that rapid infusion of NS can cause metabolic acidosis.[3]

Glucose (dextrose)

Intravenous sugar solutions, such as with glucose (also called dextrose), have the advantage of providing some energy, and may thereby provide the entire or part of the energy component of parenteral nutrition.

Types of glucose/dextrose include:

  • D5W (5% dextrose in water), which consists of 278 mmol/L dextrose
  • D5NS (5% dextrose in normal saline), which, in addition, contains normal saline.

Comparison table

Composition of common crystalloid solutions
Solution Other Name [Na+](mmol/L) [Cl-](mmol/L) [Glucose](mmol/L) [Glucose](mg/dl)
D5W 5% Dextrose 0 0 278 5000
2/3D & 1/3S 3.3% Dextrose / 0.3% saline 51 51 185 3333
Half-normal saline 0.45% NaCl 77 77 0 0
Normal saline 0.9% NaCl 154 154 0 0
Ringer's lactate Lactated Ringer 130 109 0 0
D5NS 5% Dextrose, Normal Saline 154 154 278 5000
Effect of adding one litre
Solution Change in ECF Change in ICF
D5W 333 mL 667 mL
2/3D & 1/3S 556 mL 444 mL
Half-normal saline 667 mL 333 mL
Normal saline 1000 mL 0 mL
Ringer's lactate 900 mL 100 mL

References

  1. ^ a b c An Update on Intravenous Fluids by Gregory S. Martin, MD, MSc
  2. ^ Note that in chemistry, a one normal of NaCl (see normality) is 0.5 molar (see molarity) NaCl assuming complete dissociation. Physiological dissociation is approximately 1.7 ions per mole, so one normal of NaCl is 1/1.7 = 0.588 molar. This is roughly 4 times more concentrated than medical "normal saline" of 0.154 molar.
  3. ^ Prough, DS; Bidani, A (1999). "Hyperchloremic metabolic acidosis is a predictable consequence of intraoperative infusion of 0.9% saline". Anesthesiology 90 (5): 1247–1249. doi:10.1097/00000542-199905000-00003. PMID 10319767. http://www.anesthesiology.org/pt/re/anes/fulltext.00000542-199905000-00003.htm;jsessionid=L97P825yCKJn2HYBhbyhzynlZF1lTJQyHGR1JNK7nHTvscph2xfr!536197444!181195628!8091!-1. [dead link]

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • plasma volume expander — artificial plasma extender …   Medical dictionary

  • Expander (Effet) — Le rôle d un expander en sonorisation est de diminuer le volume sonore lorsque le signal passe en dessous d un certain seuil. On peut ainsi diminuer les bruits de fond. Lorsqu on veut complètement couper le signal en dessous d un certain seuil… …   Wikipédia en Français

  • Expander (effet) — Pour les articles homonymes, voir Expandeur (homonymie). Le rôle d un expander en sonorisation est de diminuer le volume sonore lorsque le signal passe en dessous d un certain seuil. On peut ainsi diminuer les bruits de fond. Lorsqu on veut… …   Wikipédia en Français

  • expander — noun Date: 1862 one that expands; specifically any of several colloidal substances (as dextran) of high molecular weight used as a blood or plasma substitute for increasing the blood volume …   New Collegiate Dictionary

  • expander — ex·pand·er ik span dər n any of several colloidal substances (as dextran) of high molecular weight used as a blood or plasma substitute for increasing the blood volume called also extender * * * ex·pan·der (ek spanґdər) [L. expandere to… …   Medical dictionary

  • Super Expander — This article is about the VIC 20 expansion cartridge. For the corresponding C64 product, see Super Expander 64. The VIC 1211 Super Expander was a cartridge for the Commodore VIC 20 home computer. It was designed to provide several extensions to… …   Wikipedia

  • dextran — 1. Any of several water soluble high molecular weight glucose polymers (average MW 75,000; ranging between 1,000 and 40,000,000) produced by the action of members of the family Lactobacillaceae and certain other microorganisms on sucrose; used in …   Medical dictionary

  • Blood substitute — A blood substitute (also called artificial blood or blood surrogates) is a substance used to mimic and fulfill some functions of biological blood, usually in the oxygen carrying sense. They aim to provide an alternative to blood transfusion,… …   Wikipedia

  • Hemoglobin-based oxygen carriers — At the beginning of 20th century excellent work of Landsteiner and co authors combine with significant progress in fields of heart and circulation physiology initiated development of modern transfusion medicine allowing that blood transfusion… …   Wikipedia

  • Intravenous sugar solution — An intravenous sugar solution is a solution with a sugar (usually glucose or dextrose, with water as the solvent) used for intravenous therapy, where it may function both as a volume expander and a means of parenteral nutrition. Contents 1 Types… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.