Corneal dystrophy of Bowman layer, type II

Corneal dystrophy of Bowman layer, type II
Classification and external resources
OMIM 602082

Corneal dystrophy of Bowman layer, type II (CDB2), or, more commonly, Thiel-Behnke dystrophy (TBCD), is a rare form of human corneal dystrophy affecting the layer that supports corneal epithelium. Some cases of it are linked to chromosome 10q24, others stem from a mutation in the TGFBI gene.

The dystrophy was first described in 1967[1] and initially suspected to denote the same entity as the earlier-described Reis-Bucklers dystrophy, but following a study in 1995 by Kuchle et al. the two look-alike dystrophies were deemed separate disorders.[2]

References

  1. ^ Thiel HJ, Behnke H (1967). "[A hitherto unknown subepithelial hereditary corneal dystrophy]" (in German). Klin Monatsbl Augenheilkd 150 (6): 862–74. PMID 5301630. 
  2. ^ Küchle M, Green WR, Völcker HE, Barraquer J (July 1995). "Reevaluation of corneal dystrophies of Bowman's layer and the anterior stroma (Reis-Bücklers and Thiel-Behnke types): a light and electron microscopic study of eight corneas and a review of the literature". Cornea 14 (4): 333–54. doi:10.1097/00003226-199507000-00001. PMID 7671605.