Conserved non-coding sequence

A conserved non-coding sequence (CNS) is a DNA sequence of noncoding DNA that is evolutionarily conserved. These sequences are of interest for their potential to regulate gene production.[1]

CNSs in plants[2] and animals[1] are highly associated with transcription factor binding sites and other cis-acting regulatory elements. Conserved non-coding sequences can be important sites of evolutionary divergence[3] as mutations in these regions may alter the regulation of conserved genes, producing species-specific patterns of gene expression.


  1. ^ a b Hardison, RC. (Sep 2000). "Conserved noncoding sequences are reliable guides to regulatory elements.". Trends Genet 16 (9): 369–72. PMID 10973062. 
  2. ^ Glazko, GV.; Koonin, EV.; Rogozin, IB.; Shabalina, SA. (Mar 2003). "A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions.". Trends Genet 19 (3): 119–24. PMID 12615002. 
  3. ^ Prabhakar, S.; Noonan, JP.; Pääbo, S.; Rubin, EM. (Nov 2006). "Accelerated evolution of conserved noncoding sequences in humans.". Science 314 (5800): 786. doi:10.1126/science.1130738. PMID 17082449. 

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