CFU-GEMM

CFU-GEMM
Code TH H2.00.04.3.02008

CFU-GEMM is a colony forming unit that generates myeloid cells.

CFU-GEMM cells are multipotential progenitor cells.[1][2]

The "GEMM" stands for ""granulocyte, erythrocyte, monocyte, megakaryocyte".[3]

CFU-GEMM gives rise to CFU-GM.

It has been suggested that eosinophils do not derive from the common myeloid progenitor.[4]

References

  1. ^ Carow CE, Hangoc G, Broxmeyer HE (February 1993). "Human multipotential progenitor cells (CFU-GEMM) have extensive replating capacity for secondary CFU-GEMM: an effect enhanced by cord blood plasma". Blood 81 (4): 942–9. PMID 7679010. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=7679010. 
  2. ^ Roodman GD, LeMaistre CF, Clark GM, Page CP, Newcomb TF, Knight WA (August 1987). "CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan chemotherapy". Bone Marrow Transplant. 2 (2): 165–73. PMID 3332164. 
  3. ^ "Hem I WBC Morphology and Physiology". http://www.clt.astate.edu/wwilliam/hem_i_wbc_morphology_and_physiology.htm. Retrieved 2008-12-30. [dead link]
  4. ^ Mori Y, Iwasaki H, Kohno K, et al. (January 2009). "Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor". J. Exp. Med. 206 (1): 183–93. doi:10.1084/jem.20081756. PMC 2626675. PMID 19114669. http://www.jem.org/cgi/pmidlookup?view=long&pmid=19114669. 

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