Collapsin response mediator protein family


Collapsin response mediator protein family

Collapsin response mediator protein family or CRMP family consists of five intracellular phosphoproteins (CRMP1, CRMP2, CRMP3, CRMP4, CRMP5) of similar molecular size (60–66 kDa) and high (50–70%) amino acid sequence identity. CRMPs are predominantly expressed in the nervous system during development[1] and are parts to the mechanism underlying the repulsive guidance of growth cones.

References

  1. ^ Charrier E, Reibel S, Rogemond V, Aguera M, Thomasset N, Honnorat J (August 2003). "Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders". Mol. Neurobiol. 28 (1): 51–64. doi:10.1385/MN:28:1:51. PMID 14514985.