Claude's syndrome

Claude's syndrome
Classification and external resources
ICD-10 G46.3
ICD-9 352.6
DiseasesDB 33869
MeSH D020526

Claude's syndrome is a form of brainstem stroke syndrome characterized by the presence of an oculomotor nerve palsy, contralateral hemiparesis, contralateral ataxia, and contralateral hemiplegia of the lower face, tongue, and shoulder.


Cause and presentation

Human brainstem blood supply description. Posterior cerebral artery is #6, and midbrain is behind it.

Claude's syndrome is caused by midbrain infarction as a result of occlusion of a branch of the posterior cerebral artery.[1] This lesion is usually a unilateral infarction of the red nucleus and cerebral peduncle, affecting several structures in the midbrain including:

Structure damaged Effect
dentatorubral fibers contralateral ataxia
corticospinal tract fibers contralateral hemiparesis
corticobulbar tract fibers contralateral hemiplegia of lower facial muscles, tongue, and shoulder
oculomotor nerve fibers ipsilateral oculomotor nerve palsy with a drooping eyelid and fixed wide pupil pointed down and out; probable diplopia

It is very similar to Benedikt's syndrome.

Other causes

It has been reported that posterior cerebral artery stenosis can also precipitate Claude's syndrome.[2]


It carries the name of Henri Charles Jules Claude, a French psychiatrist and neurologist, who described the condition in 1912.[3]

See also


  1. ^ 691339295 at GPnotebook
  2. ^ Dhanjal T, Walters M, MacMillan N (2003). "Claude's syndrome in association with posterior cerebral artery stenosis". Scottish Medical Journal 48 (3): 91–92. PMID 12968516. 
  3. ^ Claude H, Loyez M (1912). "Ramollissement du noyau rouge". Rev Neurol (Paris) 24: 49–51. 

External links

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