A channel blocker (CB) or ion channel blocker (ICB) is a type of drug which binds inside the pore of a specific type of ion channel and blocks the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane of neurons and therefore a change in neurotransmission.
Types of Channel Blockers
There are several different major classes of channel blockers, including:
- Calcium (Ca2+) channel blockers
- ligand-gated ion channels (LGICs) via binding to their pore also exist:
- 5-HT3 receptor antagonists
- AMPA receptor antagonists
- GABAA receptor antagonists
- Glycine receptor antagonists
- Kainate receptor antagonists
- nACh receptor antagonists
- NMDA receptor antagonists
- P2X receptor antagonists
- Zinc (Zn2+)-activated channel antagonists
These types of receptor antagonists are referred to as noncompetitive or uncompetitive.
Neuromodulation Types Classessee Enzyme inhibitionCannabinoid receptor agonist • Cannabinoid receptor antagonistOtherMiscellaneous Channel blocker: potassium channel blockers Antiarrhythmic III/delayed rectifier Other/ungrouped/unknown Channel blocker: sodium channel blockers ESC blocker Other/unknown/ungrouped This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.